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Serum amyloid a truncations in type 2 diabetes mellitus.

PloS one (2015-01-22)
Hussein N Yassine, Olgica Trenchevska, Huijuan He, Chad R Borges, Dobrin Nedelkov, Wendy Mack, Naoko Kono, Juraj Koska, Peter D Reaven, Randall W Nelson
ABSTRACT

Using mass spectrometric immunoassay, the abundance of SAA truncations relative to the native variants was examined in plasma of 91 participants with type 2 diabetes and chronic kidney disease and 69 participants without diabetes. The ratio of SAA 1.1 (missing N-terminal arginine) to native SAA 1.1 was lower in diabetics compared to non-diabetics (p = 0.004), and in males compared to females (p<0.001). This ratio was negatively correlated with glycated hemoglobin (r = -0.32, p<0.001) and triglyceride concentrations (r = -0.37, p<0.001), and positively correlated with HDL cholesterol concentrations (r = 0.32, p<0.001). The relative abundance of the N-terminal arginine truncation of SAA1.1 is significantly decreased in diabetes and negatively correlates with measures of glycemic and lipid control.

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