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Sesquiterpene lactones from the aerial parts of Vernonia blumeoides growing in Nigeria.

Phytochemistry (2014-12-01)
Abubakar Babando Aliyu, Brenda Moodley, Hafizah Chenia, Neil A Koorbanally
ABSTRACT

Four eudesmanolide sesquiterpene lactones (1-4) were isolated from the aerial parts of Vernonia blumeoides used in Nigerian ethnomedicine for the treatment of diarrhea and malaria. Compound 1 demonstrated limited but interesting antibacterial activity against Bacillus, Staphylococcus and Streptococcus species. The crystal structure of 1 allowed the absolute configuration of the stereocentres in the molecule to be assigned.

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