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Panax notoginseng attenuates experimental colitis in the azoxymethane/dextran sulfate sodium mouse model.

Phytotherapy research : PTR (2013-10-22)
Xiao-Dong Wen, Chong-Zhi Wang, Chunhao Yu, Lei Zhao, Zhiyu Zhang, Adiba Matin, Yunwei Wang, Ping Li, Shu-Yuan Xiao, Wei Du, Tong-Chuan He, Chun-Su Yuan
ABSTRACT

Patients suffering from inflammatory bowel disease are at a high risk of developing colorectal cancer. To assess the anticancer potential of botanicals, in this study, we evaluated the effects of Panax notoginseng on azoxymethane/dextran sulfate sodium (DSS)-induced colitis. One week after A/J mice received azoxymethane, the animals received DSS for 8 days or were supplemented with P. notoginseng extract, at 30 or 90 mg/kg. DSS-induced colitis was scored with the disease activity index. The severity of the inflammatory lesions was evaluated by a colon tissue histological assessment. The expression of inducible nitric oxide synthase and cyclooxygenase-2 (COX-2) were also explored. We observed that the effects of P. notoginseng on the reduction of colon inflammation, expressed in disease activity index score, were in a dose-related manner (p < 0.01). P. notoginseng inhibited the reduction of the colon length and the loss of bodyweight in dose-related manner (all p < 0.05). The histological assessment of the colitis and inflammatory-related immunohistochemical data also supported the pharmacological observations. Our data suggest that P. notoginseng is a promising candidate in preventing and treating colitis and inflammation-associated colon carcinogenesis.

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