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Diagnosis and treatment of diffuse large B-cell lymphoma in an orangutan (Pongo pygmaeus).

Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians (2015-01-31)
Offiong F Ikpatt, Drury Reavill, Jason Chatfield, Susan Clubb, Joseph D Rosenblatt, Glenn Fonte, Yao-Shan Fan, Carolyn Cray
ABSTRACT

Lymphoma is a common malignancy observed in companion animals. This type of naturally occurring neoplasia has been uncommonly reported in great apes. Diffuse large B-cell lymphoma was diagnosed in an 8-yr-old captive orangutan (Pongo pygmaeus) with gastrointestinal disease by histologic and immunohistochemical methodologies. The orangutan was treated with three cycles of combination chemotherapy (intravenous Rituxan, cyclophosphamide, doxorubicin, and vincristine). The primate has been in good health and exhibiting normal behaviors for more than 15 mo following treatment.

MATERIALS
Product Number
Brand
Product Description

Doxorubicin hydrochloride, European Pharmacopoeia (EP) Reference Standard
USP
Prednisone, United States Pharmacopeia (USP) Reference Standard
Supelco
Prednisone, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
Doxorubicin hydrochloride, suitable for fluorescence, 98.0-102.0% (HPLC)
Sigma-Aldrich
Doxorubicin hydrochloride, 98.0-102.0% (HPLC)
Sigma-Aldrich
Vincristine sulfate, meets USP testing specifications
Sigma-Aldrich
Prednisone, ≥98%
USP
Doxorubicin hydrochloride, United States Pharmacopeia (USP) Reference Standard
Vincristine sulfate, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Vincristine sulfate salt, 95.0-105.0% (HPLC), powder or crystals