MilliporeSigma

Indole as an intercellular signal in microbial communities.

FEMS microbiology reviews (2010-01-15)
Jin-Hyung Lee, Jintae Lee
ABSTRACT

Bacteria can utilize signal molecules to coordinate their behavior to survive in dynamic multispecies communities. Indole is widespread in the natural environment, as a variety of both Gram-positive and Gram-negative bacteria (to date, 85 species) produce large quantities of indole. Although it has been known for over 100 years that many bacteria produce indole, the real biological roles of this molecule are only now beginning to be unveiled. As an intercellular signal molecule, indole controls diverse aspects of bacterial physiology, such as spore formation, plasmid stability, drug resistance, biofilm formation, and virulence in indole-producing bacteria. In contrast, many non-indole-producing bacteria, plants and animals produce diverse oxygenases which may interfere with indole signaling. It appears indole plays an important role in bacterial physiology, ecological balance, and possibly human health. Here we discuss our current knowledge and perspectives on indole signaling.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Indole, ≥99%
Supelco
Indole solution, 2000 μg/mL in methanol, certified reference material
Supelco
Indole, analytical standard
Sigma-Aldrich
Indole, ≥99%, FG