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Cumulative risk assessment for plasticizer-contaminated food using the hazard index approach.

Environmental pollution (Barking, Essex : 1987) (2014-03-19)
J W Chang, C Y Chen, B R Yan, M H Chang, S H Tseng, Y M Kao, J C Chen, C C Lee
ABSTRACT

Phthalates strongly and adversely affect reproduction, development and liver function. We did a cumulative risk assessment for simultaneous exposure to nine phthalates using the hazard index (HI) and the levels of nine phthalates in 1200 foodstuff samples. DEHP (di-2-ethylhexyl phthalate) present the highest level (mean: 0.443 mg/kg) in 1200 samples, and the highest average daily dose (ADD) was found in DEHP, ΣDBP(i + n) (the sum of dibutyl phthalate [DBP] isomers [DnBP + DiBP]) posed the highest risk potential of all the phthalates. In seven phthalates, the 95th percentiles of the ADDs for ΣDBP(i + n) in 0-6-yr-old children accounted for 91% (79-107%) of the tolerable daily intake, and the 95th percentiles of the HIs for the anti-androgenic effects of five phthalates in 0-3-yr-old children and 4-6-yr-old girls were >1. We conclude that the health of younger Taiwanese may be adversely affected by overexposure of phthalate-contaminated foods.

MATERIALS
Product Number
Brand
Product Description

Supelco
Di-n-butyl phthalate solution, certified reference material, 5000 μg/mL in methanol
Sigma-Aldrich
Dioctyl phthalate, ≥99.5%
Sigma-Aldrich
Dibutyl phthalate, 99%
Supelco
Bis(2-ethylhexyl) phthalate, Selectophore
Supelco
Dibutyl phthalate, PESTANAL®, analytical standard
Supelco
Bis(2-ethylhexyl) phthalate, PESTANAL®, analytical standard
Supelco
Dibutyl phthalate, Selectophore
Dibutyl phthalate, European Pharmacopoeia (EP) Reference Standard
Supelco
Dibutyl phthalate, certified reference material, TraceCERT®
Supelco
Bis(2-ethylhexyl) phthalate, certified reference material, TraceCERT®
Supelco
Bis(2-ethylhexyl) phthalate solution, certified reference material, 2000 μg/mL in methanol
Plastic additive 01, European Pharmacopoeia (EP) Reference Standard