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  • Evaluation of resveratrol and N-acetylcysteine for cancer chemoprevention in a Fanconi anemia murine model.

Evaluation of resveratrol and N-acetylcysteine for cancer chemoprevention in a Fanconi anemia murine model.

Pediatric blood & cancer (2013-10-12)
Qing-Shuo Zhang, Laura Marquez-Loza, Andrea M Sheehan, Kevin Watanabe-Smith, Laura Eaton, Eric Benedetti, Angela Major, Kathryn Schubert, Matthew Deater, Eric Joseph, Markus Grompe
ABSTRACT

Fanconi anemia (FA) patients suffer from progressive bone marrow failure and often develop cancers. Previous studies showed that antioxidants tempol and resveratrol (RV) delayed tumor onset and reduced hematologic defects in FA murine models, respectively. Here we tested whether antioxidants N-acetylcysteine (NAC) or RV could delay cancer in tumor prone Fancd2(-/-) /Trp53(+/-) mice. Unlike tempol, neither compound had any significant chemopreventive effect in this model. We conclude that not all anti-oxidants are chemopreventive in FA. In addition, when given to Fancd2(-/-) mice, NAC helped maintain Fancd2(-/-) KSL cells in quiescence while tempol did not. The mechanisms behind the different actions of these antioxidants await further investigation.

MATERIALS
Product Number
Brand
Product Description

Acetylcysteine, European Pharmacopoeia (EP) Reference Standard
USP
Acetylcysteine, United States Pharmacopeia (USP) Reference Standard
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N-Acetyl-L-cysteine, Pharmaceutical Secondary Standard; Certified Reference Material
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Resveratrol, certified reference material, TraceCERT®
Sigma-Aldrich
N-Acetyl-L-cysteine, Sigma Grade, ≥99% (TLC), powder
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Resveratrol, ≥99% (HPLC)
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N-Acetyl-L-cysteine, BioXtra, ≥99% (TLC)
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N-Acetyl-L-cysteine, BioReagent, suitable for cell culture
Resveratrol, European Pharmacopoeia (EP) Reference Standard