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Prenatal di-n-butyl phthalate exposure alters reproductive functions at adulthood in male rats.

Environmental toxicology (2012-04-11)
Nelli Giribabu, Sri Bhashyam Sainath, Pamanji Sreenivasula Reddy
ABSTRACT

This study was aimed to investigate the reproductive health in adult male rats exposed to di-n-butyl phthalate (DBP) during embryonic development. Pregnant rats were injected with DBP and F1 male rats were weaned and on postnatal day 100, used for mating with normal cycling females to assess reproductive performance. After completion of cohabitation period, rats were analyzed for other reproductive end points. Transplacental exposure to DBP significantly decreased fertility in adult male rats. Prenatal exposure to DBP significantly decreased sperm density, number of motile sperms, viable sperms, and hypoosmotic swelling tail coiled sperms with an increase in morphological abnormalities in sperms. Testicular steroidogenic enzyme activity levels and serum testosterone levels were significantly decreased in rats exposed to DBP during embryonic development. In conclusion, transplacental exposure to DBP impairs male reproductive performance by decreasing steroidogenesis and spermatogenesis.

MATERIALS
Product Number
Brand
Product Description

Supelco
Dibutyl phthalate, certified reference material, TraceCERT®
Dibutyl phthalate, European Pharmacopoeia (EP) Reference Standard
Supelco
Dibutyl phthalate, Selectophore
Sigma-Aldrich
Dibutyl phthalate, 99%
Supelco
Di-n-butyl phthalate solution, certified reference material, 5000 μg/mL in methanol
Supelco
Dibutyl phthalate, PESTANAL®, analytical standard