MilliporeSigma
  • Home
  • Search Results
  • [A case of lethal interstitial pneumonia after neoadjuvant chemotherapy for advanced gastric cancer].

[A case of lethal interstitial pneumonia after neoadjuvant chemotherapy for advanced gastric cancer].

Gan to kagaku ryoho. Cancer & chemotherapy (2014-01-08)
Keiji Kajihara, Masarou Nagamatsu, Yousuke Takeoka, Takafumi Kusaba, Yu Shigemasa, Kazuhiko Hatano, Nobufumi Sasaki, Hideki Ikari, Tadaomi Kunizaki, Kazuhiro Ooshima, Nobuhisa Yonemitsu
ABSTRACT

We report a case of lethal interstitial pneumonia that occurred after neoadjuvant chemotherapy for advanced gastric cancer. A 76-year-old man with no history of interstitial pneumonia received 2 courses of S-1 (100 mg/body) following 1 course of S-1 plus cisplatin( CDDP) from June 2012. He complained of dyspnea on exertion 6 days after completion of the treatment. Chest radiography and computed tomography (CT) revealed diffuse interstitial lesions in bilateral lung fields. Bronchoalveolar lavage( BAL) revealed an increased number of lymphocytes and leukocytes. Transbronchial lung biopsy (TBLB) revealed interstitial pneumonia with fibrous thickening in the alveolar septum. The drug lymphocyte stimulation test (DLST) was positive for S-1 and negative for CDDP. These results suggested that S-1 had induced interstitial pneumonia. Steroid therapy( 40 mg/day prednisolone following 500 mg methylprednisolone pulse therapy) and an antibiotic agent were administered but were ineffective. He rapidly developed respiratory failure and required tracheal intubation and mechanical ventilation on hospital day 24, and died on hospital day 38.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
cis-Diamineplatinum(II) dichloride, ≥99.9% trace metals basis
Sigma-Aldrich
Tegafur, ≥98% (HPLC), powder
Sigma-Aldrich
cis-Diammineplatinum(II) dichloride, crystalline
Cisplatin, European Pharmacopoeia (EP) Reference Standard