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Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells.

Immunity (2013-10-01)
Yan Gao, Simone A Nish, Ruoyi Jiang, Lin Hou, Paula Licona-Limón, Jason S Weinstein, Hongyu Zhao, Ruslan Medzhitov
ABSTRACT

CD4⁺ T cell differentiation is regulated by specialized antigen-presenting cells. Dendritic cells (DCs) produce cytokines that promote naive CD4⁺ T cell differentiation into T helper 1 (Th1), Th17, and inducible T regulatory (iTreg) cells. However, the initiation of Th2 cell responses remains poorly understood, although it is likely that more than one mechanism might be involved. Here we have defined a specific DC subset that is involved in Th2 cell differentiation in vivo in response to a protease allergen, as well as infection with Nippostrongylus brasiliensis. We have demonstrated that this subset is controlled by the transcription factor interferon regulatory factor 4 (IRF4), which is required for their differentiation and Th2 cell-inducing function. IRF4 is known to control Th2 cell differentiation and Th2 cell-associated suppressing function in Treg cells. Our finding suggests that IRF4 also plays a role in DCs where it controls the initiation of Th2 cell responses.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Albumin from chicken egg white, lyophilized powder, ≥98% (agarose gel electrophoresis)
Sigma-Aldrich
Albumin from chicken egg white, lyophilized powder
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Albumin from chicken egg white, powder, 62-88% (agarose gel electrophoresis)
Supelco
Albumin from chicken egg white, For use as a marker in SDS-PAGE
Sigma-Aldrich
Albumin from chicken egg white, lyophilized powder, ≥90% (agarose gel electrophoresis)
Sigma-Aldrich
Albumin from chicken egg white, lyophilized powder, ≥98% (agarose gel electrophoresis)