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Case report: quetiapine and refractory hypotension during general anesthesia in the operating room.

Anesthesia and analgesia (2013-07-23)
Katherine A Poole, Nina Weber, Michael Aziz
ABSTRACT

Quetiapine is an atypical antipsychotic with known α-adrenergic antagonism. We present a case of refractory hypotension that occurred after induction of general anesthesia in a patient being treated with quetiapine. This patient was not currently taking antihypertensives and had no known cardiovascular abnormalities. We observed that the hypotension was most responsive to vasopressin. We recommend further investigation regarding the interaction of quetiapine and general anesthesia.

MATERIALS
Product Number
Brand
Product Description

Supelco
Phenylephrine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
Venlafaxine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
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Lamotrigine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
Sigma-Aldrich
Venlafaxine hydrochloride, ≥98% (HPLC), powder
Venlafaxine hydrochloride, European Pharmacopoeia (EP) Reference Standard
Venlafaxine for system suitability, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Lamotrigine, ≥98%, powder
Lamotrigine for system suitability, European Pharmacopoeia (EP) Reference Standard
Lamotrigine for peak identification, European Pharmacopoeia (EP) Reference Standard
Lamotrigine, European Pharmacopoeia (EP) Reference Standard
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(R)-(−)-Phenylephrine hydrochloride, analytical standard
Sigma-Aldrich
(R)-(−)-Phenylephrine hydrochloride, powder
Phenylephrine hydrochloride for peak identification, European Pharmacopoeia (EP) Reference Standard
Supelco
R-(-)-Phenylephrine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®