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Suppression of experimental autoimmune encephalomyelitis by cannabinoids.

Immunopharmacology (1994-11-01)
I Wirguin, R Mechoulam, A Breuer, E Schezen, J Weidenfeld, T Brenner

The effect of delta 8-THC on experimental autoimmune encephalomyelitis (EAE) was examined. delta 8-THC is an analogue of delta 9-THC, the psychoactive component of marijuana. It is more stable and less psychotropic than delta 9-THC and like the latter it binds to the brain cannabinoid receptor. Two strains of rats were inoculated for EAE, and delta 8-THC (40 mg/kg) was administered for up to 21 days. delta 8-THC significantly reduced the incidence and severity of neurological deficit in both rat strains. The beneficial influence of delta 8-THC only occurred on oral administration and not with parenteral injection. Serum corticosterone levels were twofold elevated in rats with EAE chronically treated with delta 8-THC. These results suggest that suppression of EAE by cannabinoids may be related to their effect on corticosterone secretion.

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(−)-Δ8-THC solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®