Using light scattering and electron microscopic techniques, studies have been made of the swelling of liver mitochondria in isotonic sucrose solutions containing different concentrations of nitrate or acetate of monovalent thallium. It was concluded that the injurious effect of thallium on the mitochondria is associated with both its penetration into intramitochondrial space, and interaction of the external thallium with mitochondrial membranes.
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