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Self-assembled phytosterol-fructose-chitosan nanoparticles as a carrier of anticancer drug.

Journal of nanoscience and nanotechnology (2013-07-26)
Yeyan Qiu, Jun Zhu, Jianting Wang, Renmin Gong, Mingming Zheng, Fenghong Huang
ABSTRACT

Self-assembled nanoparticles were synthesized from water-soluble fructose-chitosan, substituted by succinyl linkages with phytosterols as hydrophobic moieties for self-assembly. The physicochemical properties of the prepared self-assembled nanoparticles were characterized by Fourier transform infrared spectroscopy, fluorescence spectroscopy, and transmission electron microscopy. Doxorubicin (DOX), as a model anticancer drug, was physically entrapped inside prepared self-assembled nanoparticles by the dialysis method. With increasing initial levels of the drug, the drug loading content increased, but the encapsulation efficiency decreased. The release profiles in vitro demonstrated that the DOX showed slow sustained released over 48 h, and the release rate in phosphate buffered saline (PBS) solution (pH 7.4) was much slower than in PBS solution (pH 5.5 and pH 6.5), indicating the prepared self-assembled nanoparticles had the potential to be used as a carrier for targeted delivery of hydrophobic anticancer drugs with declined cytotoxicity to normal tissues.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Chitosan from shrimp shells, low-viscous
Sigma-Aldrich
Chitosan, from shrimp shells, practical grade
Sigma-Aldrich
Chitosan, low molecular weight
Sigma-Aldrich
Chitosan, medium molecular weight
Sigma-Aldrich
Chitosan, high molecular weight
Sigma-Aldrich
Doxorubicin hydrochloride, suitable for fluorescence, 98.0-102.0% (HPLC)
Sigma-Aldrich
Doxorubicin hydrochloride, 98.0-102.0% (HPLC)
Sigma-Aldrich
Chitosan, from shrimp shells, ≥75% (deacetylated)
Doxorubicin hydrochloride, European Pharmacopoeia (EP) Reference Standard