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[A case of HER2-positive gastric cancer successfully treated with trastuzumab plus capecitabine plus cisplatin chemotherapy as third-line treatment].

Gan to kagaku ryoho. Cancer & chemotherapy (2013-07-19)
Yoriko Murata, Tetsuya Matsuura, Kenji Kanoshima, Hiroki Kuwabara, Akiko Fuyuki, Wataru Tomeno, Reo Taniguchi, Takashi Uchiyama, Hitoshi Kuriyama, Yasuo Hata
ABSTRACT

A 67-year-old woman was diagnosed as having advanced gastric cancer(poorly differentiated adenocarcinoma)with multiple liver metastases. She had received combined S-1 plus cisplatin chemotherapy as first-line treatment and weekly paclitaxel chemotherapy as second-line treatment, however, both had eventually proved ineffective. Because the gastric cancer was HER2-positive, she was treated with trastuzumab plus capecitabine plus cisplatin(XP)chemotherapy as third-line treatment. The primary lesion and liver metastatic lesions were confirmed to show remarkable regression. The ToGA trial revealed increased efficacy of trastuzumab in first-line treatment of cancers showing high expression levels of the HER2- protein. This case suggested the increased efficacy of trastuzumab in third-line treatment. Neutropenia and hand foot syndrome of grade 2 were all reported adverse events. She could receive trastuzumab plus XP chemotherapy safely by dose reduction or dormancy temporarily of capecitabine.

MATERIALS
Product Number
Brand
Product Description

Cisplatin, European Pharmacopoeia (EP) Reference Standard
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cis-Diammineplatinum(II) dichloride, crystalline
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2′-Deoxycytidine, ≥99% (HPLC)
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Fluorouracil, meets USP testing specifications
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5-Fluorouracil, ≥99% (HPLC), powder
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Fluorouracil, Pharmaceutical Secondary Standard; Certified Reference Material
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cis-Diamineplatinum(II) dichloride, ≥99.9% trace metals basis