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Design, synthesis and aromatase inhibitory activities of novel indole-imidazole derivatives.

Bioorganic & medicinal chemistry letters (2013-02-14)
Rui Wang, Hong-Fan Shi, Jing-Feng Zhao, Yan-Ping He, Hong-Bin Zhang, Jian-Ping Liu
ABSTRACT

A series of novel indole-imidazole derivatives have been prepared and evaluated in vitro on the aromatase inhibitory activities. The results suggested that proton or a small electron-withdrawing group at para-position of the phenyl ring would enhance the inhibitory activities and any bulky group should be avoided in order to keep a relative small volume for this kind of molecules.

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