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Synthesis of novel indole hydrazone derivatives and evaluation of their antiplatelet aggregation activity.

Chemical & pharmaceutical bulletin (2012-11-17)
Vida Mashayekhi, Kamaleddin Haj Mohammad Ebrahim Tehrani, Salimeh Amidi, Farzad Kobarfard
ABSTRACT

Based on the existing reports regarding the antiplatelet aggregation activity of hydrazone derivatives, a series of indole hydrazone derivatives were considered as potential antiplatelet agents and synthesized. The structures of the synthesized compounds were confirmed by spectral data and elemental analysis. The new indole hydrazone derivatives were evaluated for their ability to inhibit platelet aggregation induced by adenosine diphosphate (ADP) and arachidonic acid (AA). Compounds 1h and 3h exhibited remarkable activity against arachidonic acid induced platelet aggregation with IC(50) values comparable to that of indomethacin and compound 1i efficiently inhibited platelet aggregation induced by both ADP and AA.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Indole, ≥99%
Supelco
Indole solution, 2000 μg/mL in methanol, certified reference material
Supelco
Indole, analytical standard
Sigma-Aldrich
Indole, ≥99%, FG