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Di(2-ethylhexyl)phthalate (DEHP) and di-n-butylphthalate (DBP) exposure through diet in hospital patients.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (2012-10-31)
Teresa Cirillo, Evelina Fasano, Francesco Esposito, Paolo Montuori, Renata Amodio Cocchieri
ABSTRACT

Ready-to-eat packed meals intended to hospital patients were studied over a two-weeks period to measure the contents of di-(2-ethylhexyl) phthalate (DEHP) and di-n-butylphthalate (DBP) and to evaluate their daily intake by total diet. The packaging consisted of polyethylene terephthalate (PET) dishes sealed with polypropylene (PP) foil. The DEHP mean concentrations in total meals varied from 0.061±0.028 to 0.307±0.138μg/gwetweight (wet wt.); the DBP mean levels varied from 0.025±0.018 to 0.174±0.091μg/gwetwt. Highest levels of concentration for DEHP and DBP were found in bread with mean values of 0.307±0.138μg/gwetwt. and 0.174±0.091μg/gwetwt. for DEHP and DBP, respectively. The daily intake for DEHP was 3.1±0.9μg/kgbw and 1.5±0.5μg/kgbw for DBP. The mean±sd incidence of DEHP and DBP intake via hospital meals on the respective EFSA TDI was 6±2% (range 4-11%), and 15±5% (range 8-24%), respectively. Even if for hospital patients the major route of exposure may be represented by medical devices, the influence of the diet could have a significant value on TDI.

MATERIALS
Product Number
Brand
Product Description

Supelco
Dibutyl phthalate, certified reference material, TraceCERT®
Sigma-Aldrich
Dibutyl phthalate, 99%
Sigma-Aldrich
Dioctyl phthalate, ≥99.5%
Supelco
Dibutyl phthalate, PESTANAL®, analytical standard
Supelco
Di-n-butyl phthalate solution, certified reference material, 5000 μg/mL in methanol
Supelco
Bis(2-ethylhexyl) phthalate, Selectophore
Supelco
Bis(2-ethylhexyl) phthalate, PESTANAL®, analytical standard
Supelco
Bis(2-ethylhexyl) phthalate, certified reference material, TraceCERT®
Supelco
Dibutyl phthalate, Selectophore
Supelco
Bis(2-ethylhexyl) phthalate solution, certified reference material, 2000 μg/mL in methanol