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Membrane protein distribution in composite polymer-lipid thin films.

Chemical communications (Cambridge, England) (2012-07-28)
Johannes Thoma, Serena Belegrinou, Peggy Rossbach, Mariusz Grzelakowski, Katarzyna Kita-Tokarczyk, Wolfgang Meier
ABSTRACT

We present a model system to demonstrate that the positioning of biomolecules (membrane proteins) in a nonnative, complex thin film environment can be regulated by the phase behavior of film components. Partial separation between an amphiphilic polymer and a lipid drives the protein to a fluid phase, mechanically more similar to a cellular bilayer.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
1,2-Dipalmitoyl-sn-glycero-3-phosphocholine, semisynthetic, ≥99%
Sigma-Aldrich
1,2-Dipalmitoyl-sn-glycero-3-phosphocholine, ≥99% (TLC)