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A tandem Heck-aza-Michael addition protocol for the one-pot synthesis of isoindolines from unprotected amines.

Organic & biomolecular chemistry (2012-07-17)
Ke Chen, Sumod A Pullarkat
ABSTRACT

A palladacycle-catalyzed tandem Heck-intramolecular aza-Michael reaction protocol has been developed for the one-pot synthesis of 1-substituted isoindolines from N-unprotected 2-bromobenzylamines and acrylates with high yields.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Indoline, ReagentPlus®, 99%