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Concise enantioselective construction of a bridged azatricyclic framework via domino semipinacol-Schmidt reaction.

Chemical communications (Cambridge, England) (2012-05-03)
Manohar Puppala, Annamalai Murali, Sundarababu Baskaran
ABSTRACT

A TiCl(4)-promoted domino semipinacol-Schmidt reaction of oxaspiropentane-azide provides an easy access to bridged azatricyclic ring systems, which possess the azaquaternary center, present in the immunosupressant FR901483 and platelet aggregation inhibitor daphlongeranine B.

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