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Urinary biomarkers of occupational jet fuel exposure among Air Force personnel.

Journal of exposure science & environmental epidemiology (2011-11-03)
Kristen W Smith, Susan P Proctor, A L Ozonoff, Michael D McClean

There is a potential for widespread occupational exposure to jet fuel among military and civilian personnel. Urinary metabolites of naphthalene have been suggested for use as short-term biomarkers of exposure to jet fuel (jet propulsion fuel 8 (JP8)). In this study, urinary biomarkers of JP8 were evaluated among US Air Force personnel. Personnel (n=24) were divided a priori into high, moderate, and low exposure groups. Pre- and post-shift urine samples were collected from each worker over three workdays and analyzed for metabolites of naphthalene (1- and 2-naphthol). Questionnaires and breathing-zone naphthalene samples were collected from each worker during the same workdays. Linear mixed-effects models were used to evaluate the exposure data. Post-shift levels of 1- and 2-naphthol varied significantly by a priori exposure group (levels in high group>moderate group>low group), and breathing-zone naphthalene was a significant predictor of post-shift levels of 1- and 2-naphthol, indicating that for every unit increase in breathing-zone naphthalene, there was an increase in naphthol levels. These results indicate that post-shift levels of urinary 1- and 2-naphthol reflect JP8 exposure during the work-shift and may be useful surrogates of JP8 exposure. Among the high exposed workers, significant job-related predictors of post-shift levels of 1- and 2-naphthol included entering the fuel tank, repairing leaks, direct skin contact with JP8, and not wearing gloves during the work-shift. The job-related predictors of 1- and 2-naphthol emphasize the importance of reducing inhalation and dermal exposure through the use of personal protective equipment while working in an environment with JP8.

Product Number
Product Description

1-Naphthol, ReagentPlus®, ≥99%
1-Naphthol, BioXtra, ≥99%
1-Naphthol, puriss. p.a., reag. Ph. Eur., ≥99% (GC)
1-Naphthol, PESTANAL®, analytical standard
2-Naphthol, 99%
2-Naphthol, 98%
2-Naphthol, BioXtra, ≥99.0% (GC)
2-Naphthol, fluorescence indicator, ≥99.0%