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Synthesis and characterization of injectable, water-soluble copolymers of tertiary amine methacrylates and poly(ethylene glycol) containing methacrylates.

Biomaterials (2002-09-11)
Brian C Anderson, Surya K Mallapragada
ABSTRACT

Several homopolymers and copolymers of 2-(diethylamino)ethyl methacrylate (DEAEM) and poly(ethylene glycol) methyl ether methacrylate (PEGMEM) were synthesized using anionic polymerization initiated by potassium t-butoxide. The polymers were characterized by average molecular weight, polydispersity and monomeric unit composition. A very narrow molecular weight distribution was achieved with a well-controlled composition. The glass transition temperatures and compositions of the copolymers followed a Gordon-Taylor relationship. The water solubility and biocompatibility of the copolymers was compared to their parent homopolymers to determine if the addition of a poly(ethylene glycol) group was sufficient to solubilize the polymers in aqueous buffer solutions and to increase the biocompatibility of the polymers. These water-soluble, injectable cationic copolymers have potential applications in gene delivery as well as other biomaterial applications.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Potassium tert-butoxide solution, 1.0 M in THF
Sigma-Aldrich
Potassium tert-butoxide, sublimed grade, 99.99% trace metals basis
Sigma-Aldrich
Potassium tert-butoxide, reagent grade, ≥98%