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  • Activation of PPARgamma by metabolites from the flowers of purple coneflower (Echinacea purpurea).

Activation of PPARgamma by metabolites from the flowers of purple coneflower (Echinacea purpurea).

Journal of natural products (2009-04-21)
Kathrine B Christensen, Rasmus K Petersen, Sidsel Petersen, Karsten Kristiansen, Lars P Christensen
ABSTRACT

Thiazolidinediones are insulin sensitizing drugs that target the peroxisome proliferator-activated receptor (PPAR) gamma. An n-hexane extract of the flowers of Echinacea purpurea was found to activate PPARgamma without stimulating adipocyte differentiation. Bioassay-guided fractionations yielded five alkamides, of which one was new, and three fatty acids that all activated PPARgamma. The new alkamide hexadeca-2E,9Z,12Z,14E-tetraenoic acid isobutylamide (5) was identified by analysis of spectroscopic data and found to activate PPARgamma with no concurrent stimulation of adipocyte differentiation. Compound 5 was further shown to increase insulin-stimulated glucose uptake. The data suggest that flowers of E. purpurea contain compounds with potential to manage insulin resistance and type 2 diabetes.

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