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  • Striatal astrocytes produce neuroblasts in an excitotoxic model of Huntington's disease.

Striatal astrocytes produce neuroblasts in an excitotoxic model of Huntington's disease.

Development (Cambridge, England) (2015-02-07)
Giulia Nato, Alessia Caramello, Sara Trova, Valeria Avataneo, Chiara Rolando, Verdon Taylor, Annalisa Buffo, Paolo Peretto, Federico Luzzati
ABSTRACT

In the adult brain, subsets of astrocytic cells residing in well-defined neurogenic niches constitutively generate neurons throughout life. Brain lesions can stimulate neurogenesis in otherwise non-neurogenic regions, but whether local astrocytic cells generate neurons in these conditions is unresolved. Here, through genetic and viral lineage tracing in mice, we demonstrate that striatal astrocytes become neurogenic following an acute excitotoxic lesion. Similar to astrocytes of adult germinal niches, these activated parenchymal progenitors express nestin and generate neurons through the formation of transit amplifying progenitors. These results shed new light on the neurogenic potential of the adult brain parenchyma.

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Corn oil, delivery vehicle for fat-soluble compounds