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Theiler's virus L protein is targeted to the mitochondrial outer membrane.

Journal of virology (2011-01-14)
Frédéric Sorgeloos, Didier Vertommen, Mark H Rider, Thomas Michiels
ABSTRACT

The L protein encoded by Theiler's murine encephalomyelitis virus (TMEV) is a unique example of a picornaviral protein encoded by an alternative open reading frame. This protein is an important determinant of TMEV persistence in the mouse central nervous system. We showed that in infected cells, L is partitioned between the cytosol and the mitochondria. In mitochondria, L is anchored in the outer membrane and exposed to the cytosol. The targeting of L to mitochondria is independent of other viral components and likely depends on a conformational signal. L targeting to mitochondria might involve chaperones of the Hsp70 family, as these proteins are shown to interact.

MATERIALS
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Product Description

Sigma-Aldrich
Monoclonal Anti-β-Actin antibody produced in mouse, clone AC-15, ascites fluid
Millipore
Protein A-Sepharose® from Staphylococcus aureus, lyophilized powder