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  • Observation and modulation of the dissolution of histotripsy-induced bubble clouds with high-frame rate plane wave imaging.

Observation and modulation of the dissolution of histotripsy-induced bubble clouds with high-frame rate plane wave imaging.

Physics in medicine and biology (2019-04-18)
Kenneth B Bader, Samuel A Hendley, Gregory J Anthony, Viktor Bollen
ABSTRACT

Focused ultrasound therapies are a noninvasive means to ablate tissue. Histotripsy utilizes short ultrasound pulses with sufficient tension to nucleate bubble clouds that impart lethal strain to the surrounding tissues. Tracking bubble cloud dissolution between the application of histotripsy pulses is critical to ensure treatment efficacy. In this study, plane wave B-mode imaging was employed to monitor bubble cloud motion and grayscale at frame rates up to 11.25 kHz. Minimal changes in the area or position of the bubble clouds were observed 50 ms post excitation. The bubble cloud grayscale was observed to decrease with the square root of time, indicating a diffusion-driven process. These results were qualitatively consistent with an analytic model of gas diffusion during the histotripsy process. Finally, the rate of bubble cloud dissolution was found to be dependent on the output of the imaging pulse, indicating an interaction between the bubble cloud and imaging parameters. Overall, these results highlight the utility of plane wave B-mode imaging for monitoring histotripsy bubble clouds.

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Sigma-Aldrich
Agarose, BioReagent, for molecular biology, low EEO