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Selective anticancer effects and protection from chemotherapy by the botanical compound LCS101: Implications for cancer treatment.

Zoya Cohen et al.

International journal of oncology, 46(1), 308-316 (2014-10-22)

There is a need for new options for reducing the side effects of cancer treatment, without compromising efficacy, enabling patients to complete treatment regimens. The botanical compound LCS101 exhibits inhibitory effects on cancer cell growth, and reduces chemotherapy-induced hematological toxicities.

Beneficial role of overexpression of TFPI-2 on tumour progression in human small cell lung cancer.

Marion Lavergne et al.

FEBS open bio, 3, 291-301 (2013-08-02)

Tissue factor pathway inhibitor-2 (TFPI-2) is a potent inhibitor of plasmin, a protease which is involved in tumour progression by activating (MMPs). This therefore makes TFPI-2 a potential inhibitor of invasiveness and the development of metastases. In this study, low

Assessment of platelet function with light transmission aggregometry in 24 patients supported with a continuous-flow left ventricular assist device: a single-center experience.

Mathieu Fiore et al.

The Journal of thoracic and cardiovascular surgery, 148(6), 3119-3125 (2014-09-13)

This study evaluated platelet function for an extended period of time in patients with a HeartMate II continuous-flow left ventricular assist device (Thoratec Corporation, Pleasanton, Calif) with light transmission aggregometry and investigated the potential role of this test in clinical

Glial β-oxidation regulates Drosophila energy metabolism.

Joachim G Schulz et al.

Scientific reports, 5, 7805-7805 (2015-01-16)

The brain's impotence to utilize long-chain fatty acids as fuel, one of the dogmas in neuroscience, is surprising, since the nervous system is the tissue most energy consuming and most vulnerable to a lack of energy. Challenging this view, we

Phenylbutyrate induces cathelicidin expression via the vitamin D receptor: Linkage to inflammatory and growth factor cytokines pathways.

Nikhil N Kulkarni et al.

Molecular immunology, 63(2), 530-539 (2014-12-03)

Antimicrobial peptides (AMPs) constitute an indispensable arm of innate immunity against infectious microbes in humans. Induction of endogenous AMPs may become an alternative therapy against infections. Our previous studies have demonstrated phenylbutyrate (PBA) as a novel inducer of the AMPs

Carbon nanotubes induce apoptosis resistance of human lung epithelial cells through FLICE-inhibitory protein.

Varisa Pongrakhananon et al.

Toxicological sciences : an official journal of the Society of Toxicology, 143(2), 499-511 (2014-11-22)

Chronic exposure to single-walled carbon nanotubes (SWCNT) has been reported to induce apoptosis resistance of human lung epithelial cells. As resistance to apoptosis is a foundation of neoplastic transformation and cancer development, we evaluated the apoptosis resistance characteristic of the

H89 enhances the sensitivity of cancer cells to glyceryl trinitrate through a purinergic receptor-dependent pathway.

Marion Cortier et al.

Oncotarget, 6(9), 6877-6886 (2015-03-13)

High doses of the organic nitrate glyceryl trinitrate (GTN), a nitric oxide (NO) donor, are known to trigger apoptosis in human cancer cells. Here, we show that such a cytotoxic effect can be obtained with subtoxic concentrations of GTN when

Accelerated onset of senescence of endothelial progenitor cells in patients with type 2 diabetes mellitus: role of dimethylarginine dimethylaminohydrolase 2 and asymmetric dimethylarginine.

Qiong Yuan et al.

Biochemical and biophysical research communications, 458(4), 869-876 (2015-02-24)

The risk of cardiovascular complications in diabetic patients is mainly associated with endothelial dysfunction. Reduced number of EPCs and impaired function of EPCs in diabetes result in imbalance of endothelial homeostasis and dysfunction of vessels. In patients with diabetes mellitus

Cell-penetrating antimicrobial peptides - prospectives for targeting intracellular infections.

Jesper S Bahnsen et al.

Pharmaceutical research, 32(5), 1546-1556 (2015-03-18)

To investigate the suitability of three antimicrobial peptides (AMPs) as cell-penetrating antimicrobial peptides. Cellular uptake of three AMPs (PK-12-KKP, SA-3 and TPk) and a cell-penetrating peptide (penetratin), all 5(6)-carboxytetramethylrhodamine-labeled, were tested in HeLa WT cells and analyzed by flow cytometry

Hepatocyte growth factor gene-modified adipose-derived mesenchymal stem cells ameliorate radiation induced liver damage in a rat model.

Jiamin Zhang et al.

PloS one, 9(12), e114670-e114670 (2014-12-17)

Liver damage caused by radiotherapy is associated with a high mortality rate, but no established treatment exists. Adipose-derived mesenchymal stem cells (ADSCs) are capable of migration to injured tissue sites, where they aid in the repair of the damage. Hepatocyte

Immune escape phenomenon in molluscum contagiosum and the induction of apoptosis.

Akiko Yamauchi-Yamada et al.

The Journal of dermatology, 41(12), 1058-1064 (2014-12-03)

Molluscum contagiosum (MC) may persist for many weeks, evading host immunity. We studied the mechanism of immune escape phenomenon in MC, and the possible inducer of apoptosis. Using tissue samples of MC, we examined the numbers of epidermal Langerhans cells

Wogonin induces cell cycle arrest and erythroid differentiation in imatinib-resistant K562 cells and primary CML cells.

Hao Yang et al.

Oncotarget, 5(18), 8188-8201 (2014-08-26)

Wogonin, a flavonoid derived from Scutellaria baicalensis Georgi, has been demonstrated to be highly effective in treating hematologic malignancies. In this study, we investigated the anticancer effects of wogonin on K562 cells, K562 imatinib-resistant cells, and primary patient-derived CML cells.

Blocking cold-inducible RNA-binding protein protects liver from ischemia-reperfusion injury.

Andrew Godwin et al.

Shock (Augusta, Ga.), 43(1), 24-30 (2014-09-05)

Cold-inducible RNA-binding protein (CIRP) is a nuclear protein that has been recently identified as a novel inflammatory mediator in hemorrhagic shock and sepsis. We hypothesized that CIRP acts as a potent inflammatory mediator in hepatic ischemia-reperfusion (I/R), and thus blocking

MiR-21, miR-34a, miR-198 and miR-217 as diagnostic and prognostic biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinoma.

Petra Vychytilova-Faltejskova et al.

Diagnostic pathology, 10, 38-38 (2015-04-25)

Pancreatic ductal adenocarcinoma is an aggressive malignancy with late presentation, metastatic potential and very poor prognosis. Therefore, there is an urgent need for novel diagnostic and prognostic biomarkers. MicroRNAs are small non-coding RNAs that post-transcriptionally regulate gene expression. Altered expression

Image-based RNA interference screening reveals an individual dependence of acute lymphoblastic leukemia on stromal cysteine support.

Jeannette Boutter et al.

Oncotarget, 5(22), 11501-11512 (2014-11-22)

Interactions with the bone marrow microenvironment are essential for leukemia survival and disease progression. We developed an imaging-based RNAi platform to identify protective cues from bone marrow derived mesenchymal stromal cells (MSC) that promote survival of primary acute lymphoblastic leukemia

Saturated fatty acids modulate autophagy's proteins in the hypothalamus.

Mariana Portovedo et al.

PloS one, 10(3), e0119850-e0119850 (2015-03-19)

Autophagy is an important process that regulates cellular homeostasis by degrading dysfunctional proteins, organelles and lipids. In this study, the hypothesis that obesity could lead to impairment in hypothalamic autophagy in mice was evaluated by examining the hypothalamic distribution and

Complement protein C1q modulates neurite outgrowth in vitro and spinal cord axon regeneration in vivo.

Sheri L Peterson et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(10), 4332-4349 (2015-03-13)

Traumatic injury to CNS fiber tracts is accompanied by failure of severed axons to regenerate and results in lifelong functional deficits. The inflammatory response to CNS trauma is mediated by a diverse set of cells and proteins with varied, overlapping

Identification and characterization of ML352: a novel, noncompetitive inhibitor of the presynaptic choline transporter.

Elizabeth A Ennis et al.

ACS chemical neuroscience, 6(3), 417-427 (2015-01-07)

The high-affinity choline transporter (CHT) is the rate-limiting determinant of acetylcholine (ACh) synthesis, yet the transporter remains a largely undeveloped target for the detection and manipulation of synaptic cholinergic signaling. To expand CHT pharmacology, we pursued a high-throughput screen for

Study of the Structure-Function-Stability Relationships in Yeast D-amino Acid Oxidase: Hydrophobization of Alpha-Helices.

I V Golubev et al.

Acta naturae, 6(3), 76-88 (2014-10-29)

Hydrophobization of alpha-helices is one of the general approaches used for improving the thermal stability of enzymes. A total of 11 serine residues located in alpha-helices have been found based on multiple alignments of the amino acid sequences of D-amino

Antisense growth inhibition of methicillin-resistant Staphylococcus aureus by locked nucleic acid conjugated with cell-penetrating peptide as a novel FtsZ inhibitor.

Jingru Meng et al.

Antimicrobial agents and chemotherapy, 59(2), 914-922 (2014-11-26)

Methicillin-resistant Staphylococcus aureus (MRSA) infections are becoming increasingly difficult to treat, owing to acquired antibiotic resistance. The emergence and spread of MRSA limit therapeutic options and require new therapeutic strategies, including novel MRSA-active antibiotics. Filamentous temperature-sensitive protein Z (FtsZ) is

Implications of protein corona on physico-chemical and biological properties of magnetic nanoparticles.

Murali M Yallapu et al.

Biomaterials, 46, 1-12 (2015-02-14)

Interaction of serum proteins and nanoparticles leads to a nanoparticle-protein complex formation that defines the rational strategy for a clinically relevant formulation for drug delivery, hyperthermia, and magnetic resonance imaging (MRI) applications in cancer nanomedicine. Given this perspective, we have

The Ca²⁺-calmodulin-Ca²⁺/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes.

Flavia D Toledo et al.

Archives of toxicology, 88(9), 1695-1709 (2014-03-13)

Oxidative stress (OS) is a common event in most hepatopathies, leading to mitochondrial permeability transition pore (MPTP) formation and further exacerbation of both OS from mitochondrial origin and cell death. Intracellular Ca²⁺ increase plays a permissive role in these events

EDI3 links choline metabolism to integrin expression, cell adhesion and spreading.

Michaela S Lesjak et al.

Cell adhesion & migration, 8(5), 499-508 (2014-12-09)

Endometrial carcinoma differential 3 (EDI3) was the first member of the glycerophosphodiesterase (GDE) protein family shown to be associated with cancer. Our initial work demonstrated that endometrial and ovarian cancer patients with primary tumors overexpressing EDI3 had a higher risk

Targeting vascular endothelial growth factor receptor 2 and protein kinase D1 related pathways by a multiple kinase inhibitor in angiogenesis and inflammation related processes in vitro.

Attila Varga et al.

PloS one, 10(4), e0124234-e0124234 (2015-04-16)

Emerging evidence suggests that the vascular endothelial growth factor receptor 2 (VEGFR2) and protein kinase D1 (PKD1) signaling axis plays a critical role in normal and pathological angiogenesis and inflammation related processes. Despite all efforts, the currently available therapeutic interventions

A novel ERCC6 splicing variant associated with a mild Cockayne syndrome phenotype.

Jonathan M Swartz et al.

Hormone research in paediatrics, 82(5), 344-352 (2014-11-08)

Cockayne syndrome is an autosomal recessive, heterogeneous syndrome with classical features, including short stature, microcephaly, developmental delay, neuropathy, and photosensitivity. New genomic approaches offer improved molecular diagnostic potential. Whole-exome sequencing was employed to study a consanguineous extended family with severe

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer's disease mouse model.

Gerhard Leinenga et al.

Science translational medicine, 7(278), 278ra33-278ra33 (2015-03-13)

Amyloid-β (Aβ) peptide has been implicated in the pathogenesis of Alzheimer's disease (AD). We present a nonpharmacological approach for removing Aβ and restoring memory function in a mouse model of AD in which Aβ is deposited in the brain. We

Protein encapsulated core-shell structured particles prepared by coaxial electrospraying: investigation on material and processing variables.

Maedeh Zamani et al.

International journal of pharmaceutics, 473(1-2), 134-143 (2014-07-08)

Biodegradable polymeric particles have been extensively investigated for controlled drug delivery of various therapeutic agents. 'Coaxial' electrospraying was successfully employed in this study, to fabricate core-shell PLGA particles containing bovine serum albumin (BSA) as the model protein, and the results

Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth.

Leili Ran et al.

Cancer discovery, 5(3), 304-315 (2015-01-13)

Gastrointestinal stromal tumor (GIST), originating from the interstitial cells of Cajal (ICC), is characterized by frequent activating mutations of the KIT receptor tyrosine kinase. Despite the clinical success of imatinib, which targets KIT, most patients with advanced GIST develop resistance

The genome-wide effects of ionizing radiation on mutation induction in the mammalian germline.

Adeolu B Adewoye et al.

Nature communications, 6, 6684-6684 (2015-03-27)

The ability to predict the genetic consequences of human exposure to ionizing radiation has been a long-standing goal of human genetics in the past 50 years. Here we present the results of an unbiased, comprehensive genome-wide survey of the range

Induction of cell cycle arrest and apoptosis in caspase-3 deficient MCF-7 cells by Dillenia suffruticosa root extract via multiple signalling pathways.

Jhi Biau Foo et al.

BMC complementary and alternative medicine, 14, 197-197 (2014-06-21)

Dillenia suffruticosa root dichloromethane extract (DCM-DS) has been reported to exhibit strong cytotoxicity towards breast cancer cells. The present study was designed to investigate the cell cycle profile, mode of cell death and signalling pathways of DCM-DS-treated human caspase-3 deficient

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