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Mohsen Saeedi et al.
Journal of environmental management, 214, 204-214 (2018-03-12)
The effects of soil components such as clay minerals and as humic acids, as well as co-existing metals and polycyclic aromatic hydrocarbons, on desorption and mobility are examined. Three types of artificially blended clay and clay mineral mixtures (pure kaolinite...
Samantha T Clark et al.
Colloids and surfaces. B, Biointerfaces, 187, 110609-110609 (2019-12-07)
The effects of lipid charge and head group size on liposome partitioning by detergents is an important consideration for applications such as liposomal drug delivery or proteoliposome formation. Yet, the solubilization of mixed-lipid liposomes, those containing multiple types of lipids...
Marta Vignola et al.
Water research, 143, 66-76 (2018-06-26)
Rapid quantification of absolute microbial cell abundances is important for a comprehensive interpretation of microbiome surveys and crucial to support theoretical modelling and the design of engineered systems. In this paper, we propose a protocol specifically optimised for the quantification...
Roberto Gaetani et al.
Tissue engineering. Part C, Methods (2018-11-07)
Different approaches have investigated the effects of the different extracellular matrices (ECMs) and 3D culture on islets function, showing encouraging results. Ideally, the proper scaffold should mimic the biochemical composition of the native tissue as it drives numerous signaling pathways...
Steve M Nelson et al.
Developmental biology, 328(1), 24-39 (2009-02-13)
Retinal homeobox (Rx/Rax) genes are essential for the organogenesis of the vertebrate eye. These genes are dynamically expressed in a tissue-specific manner during eye development, suggesting pleiotropic roles. We use a temporally-selective gene knockdown approach to identify endogenous functions for...
Sarah Louise Dombernowsky et al.
Nature communications, 6, 7518-7518 (2015-06-26)
The metalloproteinase ADAM17 activates ErbB signalling by releasing ligands from the cell surface, a key step underlying epithelial development, growth and tumour progression. However, mechanisms acutely controlling ADAM17 cell-surface availability to modulate the extent of ErbB ligand release are poorly...
David Putzer et al.
Biopreservation and biobanking, 15(5), 410-416 (2017-07-08)
Allografts are used to compensate for bone defects resulting from revision surgery, tumor surgery, and reconstructive bone surgery. Although it is well known that the reduction of fat content of allografts increases mechanical properties, the content of liquids with a...
Xuefeng He et al.
Journal of hazardous materials, 358, 346-354 (2018-07-14)
In this work, a photocatalytic fuel cell (PFC) with membrane electrode assembly (MEA) structure was designed for simultaneous organic compounds degradation and electricity generation. For the photoanode, the TiO2 with the quantum-dot sensitization by CdS-ZnS was used to broaden the...
Lin Wang et al.
Nature communications, 10(1), 746-746 (2019-02-16)
Excessive or uncontrolled release of proinflammatory cytokines caused by severe viral infections often results in host tissue injury or even death. Phospholipase C (PLC)s degrade phosphatidylinositol-4, 5-bisphosphate (PI(4,5)P2) lipids and regulate multiple cellular events. Here, we report that PLCβ2 inhibits...
Tahseen H Nasti et al.
Life sciences, 131, 11-18 (2015-04-14)
P-selectin is an adhesion receptor that is mainly present on endothelial cells and platelets. We investigated the role of P-selectin in the regulation of different T cell subsets in the tumor microenvironment, and how that influences the growth and metastasis...
Xinnuo Lei et al.
Molecular and cellular endocrinology, 411, 207-213 (2015-05-11)
Obesity and its associated morbidities represent one of the major and most rapidly expanding health epidemics in the world. Recent genome-wide association studies (GWAS) have identified several variants in LYPLAL1 gene that are significantly associated with central obesity preferentially in...
Xin Liu et al.
Scientific reports, 6, 39735-39735 (2016-12-23)
Excessive activation of the TLR4 signalling pathway is critical for inflammation-associated disorders, while negative regulators play key roles in restraining TLR4 from over-activation. Naringenin is a citrus flavonoid with remarkable anti-inflammatory activity, but the mechanisms underlying its inhibition of LPS/TLR4...
Camila Morais Gonçalves da Silva et al.
PloS one, 12(10), e0185828-e0185828 (2017-10-06)
Ropivacaine is a local anesthetic with similar potency but lower systemic toxicity than bupivacaine, the most commonly used spinal anesthetic. The present study concerns the development of a combined drug delivery system for ropivacaine, comprised of two types of liposomes:...
Mahsa Rostamian Delavar et al.
Gene, 662, 54-65 (2018-04-10)
Parkinson's disease (PD) is a debilitating neurodegenerative condition characterized by the loss of dopaminergic neurons in substantia nigra. MPP+ as a dopaminergic neurotoxin induces many parkinsonian-like symptoms in cell culture. MicroRNAs are noncoding RNAs which their deregulation participates in neurodegeneration...
David Schwenninger et al.
Journal of applied physiology (Bethesda, Md. : 1985), 123(1), 27-37 (2017-04-01)
Optical clearing allows tissue visualization under preservation of organ integrity. Optical clearing of organs with a physiological change in three-dimensional geometry (such as the lung) would additionally allow visualization of macroscopic and microscopic tissue geometry. A prerequisite, however, is the...
David Andrés Nocera et al.
Journal of immunology (Baltimore, Md. : 1950), 196(6), 2860-2869 (2016-02-18)
The crucial role that endogenously produced IFN-β plays in eliciting an immune response against cancer has recently started to be elucidated. Endogenous IFN-β has an important role in immune surveillance and control of tumor development. Accordingly, the role of TLR...
Hui Dong et al.
Parasites & vectors, 9(1), 602-602 (2016-11-26)
Silent information regulator 2 (SIR2) proteins are a family of NAD + -dependent protein deacetylases that are considered potential targets for anti-parasitic agents. In this study, we cloned and characterized SIR2A of the protozoan parasite Eimeria tenella (EtSIR2A) and investigated its protective...
Nuno Carinhas et al.
Scientific reports, 6, 23529-23529 (2016-03-24)
Canine adenovirus vector type 2 (CAV2) represents an alternative to human adenovirus vectors for certain gene therapy applications, particularly neurodegenerative diseases. However, more efficient production processes, assisted by a greater understanding of the effect of infection on producer cells, are...
Kate Sutton et al.
Veterinary research, 49(1), 104-104 (2018-10-12)
The respiratory tract is a key organ for many avian pathogens as well as a major route for vaccination in the poultry industry. To improve immune responses after vaccination of chickens through increased uptake of vaccines and targeting to antigen...
Lee Moir et al.
Molecular metabolism, 6(11), 1419-1428 (2017-11-07)
Genetic studies in obese rodents and humans can provide novel insights into the mechanisms involved in energy homeostasis. In this study, we genetically mapped the chromosomal region underlying the development of severe obesity in a mouse line identified as part...
Michał Bulc et al.
Journal of diabetes research, 2018, 4735659-4735659 (2018-08-25)
One of the most frequently reported disorders associated with diabetes is gastrointestinal (GI) disturbance. Although pathogenesis of these complications is multifactorial, the complicity of the enteric nervous system (ENS) in this respect has significant importance. Therefore, this paper analysed changes...
Wenquan Ou et al.
ACS applied materials & interfaces, 11(40), 36333-36346 (2019-09-20)
Cell-based delivery platforms have received great interest in recent years and have been indicated as a promising strategy for cancer immunotherapy. Despite their wide applications in the clinical and preclinical stages, their concomitant viability and efficacy remain major issues. Herein...
Bernd Denecke et al.
Journal of tissue engineering and regenerative medicine, 9(11), E84-E97 (2013-02-26)
One of the major challenges in tissue engineering is to supply larger three-dimensional (3D) bioengineered tissue transplants with sufficient amounts of nutrients and oxygen and to allow metabolite removal. Consequently, artificial vascularization strategies of such transplants are desired. One strategy...
Alexander V Zhdanov et al.
Biochimica et biophysica acta, 1847(10), 1254-1266 (2015-07-06)
Abnormal accumulation of oncometabolite fumarate and succinate is associated with inhibition of mitochondrial function and carcinogenesis. By competing with α-ketoglutarate, oncometabolites also activate hypoxia inducible factors (HIFs), which makes oncometabolite mimetics broadly utilised in hypoxia research. We found that dimethyloxalylglycine...
Camillo Sargiacomo et al.
Stem cell research & therapy, 8(1), 204-204 (2017-10-01)
Hepatitis B virus (HBV) carriers worldwide number approximately 240 million people and around 780,000 people die every year from HBV infection. HBV entry and uptake are functionally linked to the presence of the human sodium-taurocholate cotransporting peptide (hNTCP) receptor. Recently...
Hanqing Chen et al.
Nanotoxicology, 9(3), 302-312 (2014-06-26)
The potential impacts of nanomaterials (NMs) on fetal development have attracted great concerns because of the increased potential exposure to NMs during pregnancy. Drosophila melanogaster oogenesis and developmental transitions may provide an attractive system to study the biological and environmental...
Marta Pajares et al.
Autophagy, 14(8), 1310-1322 (2018-06-29)
Chaperone-mediated autophagy (CMA) is a selective degradative process for cytosolic proteins that contributes to the maintenance of proteostasis. The signaling mechanisms that control CMA are not fully understood but might involve response to stress conditions including oxidative stress. Considering the...
Erik C Gunther et al.
Cell reports, 26(1), 145-158 (2019-01-04)
Cellular prion protein (PrPC) binds the scrapie conformation of PrP (PrPSc) and oligomeric β-amyloid peptide (Aβo) to mediate transmissible spongiform encephalopathy (TSE) and Alzheimer's disease (AD), respectively. We conducted cellular and biochemical screens for compounds blocking PrPC interaction with Aβo....
Andreia V Mendes et al.
Biochimica et biophysica acta, 1863(1), 139-147 (2015-11-03)
Protein modification with the small ubiquitin-like modifier (SUMO) is a reversible process regulating many central biological pathways. The reversibility of SUMOylation is ensured by SUMO proteases many of which belong to the sentrin/SUMO-specific protease (SENP) family. In recent years, many...
Miriam Durante et al.
Toxicology in vitro : an international journal published in association with BIBRA, 44, 241-247 (2017-07-27)
The P-glicoprotein (P-gp) inhibitor tariquidar is used to detect functional alterations of blood brain barrier pumps in PET imaging. The doses required, however, up to 4-fold higher than those already used in clinical trials to reverse multidrug resistance, cause syncopal...