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Anna Sheveleva et al.
Virus genes, 47(2), 385-388 (2013-07-03)
The near-complete (99.7 %) genome sequence of a novel Russian Plum pox virus (PPV) isolate Pk, belonging to the strain Winona (W), has been determined by 454 pyrosequencing with the exception of the thirty-one 5'-terminal nucleotides. This region was amplified using
Raquel Batlle et al.
Nature communications, 10(1), 3071-3071 (2019-07-13)
The formation of new blood vessels is essential for normal development, tissue repair and tumor growth. Here we show that inhibition of the kinase p38α enhances angiogenesis in human and mouse colon tumors. Mesenchymal cells can contribute to tumor angiogenesis
Ruth Scheicher et al.
Blood, 125(1), 90-101 (2014-10-25)
The cyclin-dependent kinase 6 (CDK6) and CDK4 have redundant functions in regulating cell-cycle progression. We describe a novel role for CDK6 in hematopoietic and leukemic stem cells (hematopoietic stem cells [HSCs] and leukemic stem cells [LSCs]) that exceeds its function
Geoffrey H Siwo et al.
BMC genomics, 16, 1030-1030 (2015-12-08)
Transcriptional responses to small molecules can provide insights into drug mode of action (MOA). The capacity of the human malaria parasite, Plasmodium falciparum, to respond specifically to transcriptional perturbations has been unclear based on past approaches. Here, we present the
Ivan Petrov et al.
Aging, 8(11), 2936-2947 (2016-11-22)
Acute lymphoblast leukemia (ALL) is characterized by overproduction of immature white blood cells in the bone marrow. ALL is most common in the childhood and has high (>80%) cure rate. In contrast, acute myeloid leukemia (AML) has far greater mortality
Norman N Iscove et al.
Nature biotechnology, 20(9), 940-943 (2002-08-13)
Analysis of transcript representation on gene microarrays requires microgram amounts of total RNA or DNA. Without amplification, such amounts are obtainable only from millions of cells. However, it may be desirable to determine transcript representation in few or even single
Claude Kwe Yinda et al.
Emerging microbes & infections, 6(5), e38-e38 (2017-05-26)
Sapoviruses (SaVs) belong to the Sapovirus genus, in the family Caliciviridae. They have been associated with gastroenteritis in humans and in pigs but not in other animals. In addition, some strains from pigs, chimpanzees and rodents show close sequence identity
Hanène Badri et al.
PloS one, 10(8), e0135565-e0135565 (2015-08-27)
The edible cyanobacterium Arthrospira is resistant to ionising radiation. The cellular mechanisms underlying this radiation resistance are, however, still largely unknown. Therefore, additional molecular analysis was performed to investigate how these cells can escape from, protect against, or repair the
Nádia Conceição-Neto et al.
Ecology and evolution, 7(12), 4135-4146 (2017-06-27)
Animal host-microbe interactions are a relevant concern for wildlife conservation, particularly regarding generalist pathogens, where domestic host species can play a role in the transmission of infectious agents, such as viruses, to wild animals. Knowledge on viral circulation in wild
Chihiro Mori et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(3), 878-889 (2015-01-23)
Complex learned behavior is influenced throughout development by both genetic and environmental factors. Birdsong, like human speech, is a complex vocal behavior acquired through sensorimotor learning and is based on coordinated auditory input and vocal output to mimic tutor song.
Rita Vassena et al.
Development (Cambridge, England), 138(17), 3699-3709 (2011-07-22)
The events regulating human preimplantation development are still largely unknown owing to a scarcity of material, ethical and legal limitations and a lack of reliable techniques to faithfully amplify the transcriptome of a single cell. Nonetheless, human embryology is gathering
Claudia Kohl et al.
PloS one, 7(8), e43106-e43106 (2012-08-21)
In recent years novel human respiratory disease agents have been described in South East Asia and Australia. The causative pathogens were classified as pteropine orthoreoviruses with strong phylogenetic relationship to orthoreoviruses of flying foxes inhabiting these regions. Subsequently, a zoonotic
Rowena Chong et al.
Journal of virology, 93(11) (2019-03-15)
The Tasmanian devil is an endangered carnivorous marsupial threatened by devil facial tumor disease (DFTD). While research on DFTD has been extensive, little is known about viruses in devils and whether any are of potential conservation relevance for this endangered
Jana Van Dycke et al.
PLoS pathogens, 15(9), e1008009-e1008009 (2019-09-20)
Human noroviruses (HuNoVs) are the most common cause of foodborne illness, with a societal cost of $60 billion and 219,000 deaths/year. The lack of robust small animal models has significantly hindered the understanding of norovirus biology and the development of
Prachi Pratap Singh et al.
Traffic (Copenhagen, Denmark), 16(6), 555-571 (2015-03-11)
Exosomes are extracellular vesicles released by cells that carry proteins, lipids and nucleic acids and function in intercellular communication. Previously, we determined that exosomes released from Mycobacterium tuberculosis (M.tb)-infected macrophages carry mycobacterial proteins and lipids. However, the RNA composition within
Yan Wei Lim et al.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 12(2), 154-164 (2012-09-07)
Samples collected from CF patient airways often contain large amounts of host-derived nucleic acids that interfere with recovery and purification of microbial and viral nucleic acids. This study describes metagenomic and metatranscriptomic methods that address these issues. Microbial and viral
Adriana von Teichman et al.
Virchows Archiv : an international journal of pathology, 461(5), 571-580 (2012-09-26)
The use of whole genome amplification (WGA) and whole transcriptome amplification (WTA) techniques enables the enrichment of DNA and RNA from very small amounts of tissue. Here, we tested the suitability of WGA and WTA for tumor tissue biobanking. DNA
137 differential gene expression of in vitro-matured bovine oocytes with or without a polar body.
M. M. Pereira et al.
Reproduction, Fertility, and Development, 24(1), 181-181 (2011)
Phuong-Nam Nguyen et al.
European urology, 59(3), 407-414 (2010-12-15)
The TMPRSS2:ERG fusion is both prevalent and unique to prostate cancer (PCa) and has great potential for noninvasive diagnosis of PCa in bodily fluids. To evaluate the specificity and sensitivity of the TMPRSS2:ERG fusion in urine from diverse clinical contexts
Orily Depraetere et al.
PloS one, 10(7), e0132461-e0132461 (2015-07-22)
Cyanobacteria have a strong potential for biofuel production due to their ability to accumulate large amounts of carbohydrates. Nitrogen (N) stress can be used to increase the content of carbohydrates in the biomass, but it is expected to reduce biomass
María López-Malo et al.
BMC genomics, 16, 537-537 (2015-07-22)
Wine produced at low temperature is often considered to improve sensory qualities. However, there are certain drawbacks to low temperature fermentations: e.g. low growth rate, long lag phase, and sluggish or stuck fermentations. Selection and development of new Saccharomyces cerevisiae
Javier Mariscal et al.
Scientific reports, 6, 37820-37820 (2016-12-03)
Knowledge on the molecular mechanisms underlying metastasis colonization in Non-Small Cell Lung Cancer (NSCLC) remains incomplete. A complete overview integrating driver mutations, primary tumour heterogeneity and overt metastasis lacks the dynamic contribution of disseminating metastatic cells due to the inaccessibility
Sonja Lang et al.
Gastroenterology, 159(5), 1839-1852 (2020-07-12)
Alterations in the gut microbiome have been associated with the severity of nonalcoholic fatty liver disease (NAFLD). Previous studies focused exclusively on the bacteria in the microbiome; we investigated changes in the viral microbiome (virome) in patients with NAFLD. In
Caroline Charre et al.
Virus evolution, 6(2), veaa075-veaa075 (2020-12-16)
Since the beginning of the COVID-19 outbreak, SARS-CoV-2 whole-genome sequencing (WGS) has been performed at unprecedented rate worldwide with the use of very diverse Next-Generation Sequencing (NGS) methods. Herein, we compare the performance of four NGS-based approaches for SARS-CoV-2 WGS.
Sanela Svraka et al.
The Journal of general virology, 91(Pt 11), 2846-2856 (2010-07-28)
The use of metagenomics for virus discovery in clinical samples has opened new opportunities for understanding the aetiology of unexplained illness. This study explores the potential of this sequence-independent approach in a public-health setting, by systematic analysis of samples cultured
Sara Cano-Crespo et al.
Scientific reports, 9(1), 14065-14065 (2019-10-03)
CD98 heavy chain (CD98hc) forms heteromeric amino acid (AA) transporters by interacting with different light chains. Cancer cells overexpress CD98hc-transporters in order to meet their increased nutritional and antioxidant demands, since they provide branched-chain AA (BCAA) and aromatic AA (AAA)
Marco Pellino et al.
Genes, 11(7) (2020-07-08)
Apomixis, the asexual reproduction via seeds, is associated to polyploidy and hybridization. To identify possible signatures of apomixis, and possible candidate genes underlying the shift from sex to apomixis, microarray-based gene expression patterns of live microdissected ovules at four different
C De Paepe et al.
Molecular reproduction and development, 86(1), 53-62 (2018-10-30)
Comprehensive understanding of lineage differentiation and apoptosis processes is important to increase our knowledge of human preimplantation development in vitro. We know that BMP signaling is important for different processes during mammalian development. In mouse preimplantation embryos, BMP signaling has
Lindsey B Turnbull et al.
PloS one, 12(11), e0187595-e0187595 (2017-11-08)
Gene expression DNA microarrays have been vital for characterizing whole-genome transcriptional profiles. Nevertheless, their effectiveness relies heavily on the accuracy of genome sequences, the annotation of gene structures, and the sequence-dependent performance of individual probes. Currently available gene expression arrays
Lee-Ann Tjon-Kon-Fat et al.
The Prostate, 78(1), 48-53 (2017-11-03)
Novel therapies for castration resistant prostate cancer (CRPC) have been introduced in the clinic with possibilities for individualized treatment plans. Best practice of those expensive drugs requires predictive biomarker monitoring. This study used circulating biomarker analysis to follow cancer-derived transcripts
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