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Rapid and generic identification of influenza A and other respiratory viruses with mass spectrometry.

Joanna A Majchrzykiewicz-Koehorst et al.

Journal of virological methods, 213, 75-83 (2014-12-17)

The rapid identification of existing and emerging respiratory viruses is crucial in combating outbreaks and epidemics. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a rapid and reliable identification method in bacterial diagnostics, but has not been used in

Cytotoxic compounds from the marine-derived fungus Aspergillus sp. recovered from the sediments of the Brazilian coast.

Natália N Saraiva et al.

Natural product research, 29(16), 1545-1550 (2014-12-24)

A fungal strain of Aspergillus sp. (BRF 030) was isolated from the sediments collected in the northeast coast of Brazil, and the cytotoxic activity of its secondary metabolites was investigated against HCT-116 tumour cell line. The cytotoxicity-guided fractionation of the

The p53-inducible gene 3 involved in flavonoid-induced cytotoxicity through the reactive oxygen species-mediated mitochondrial apoptotic pathway in human hepatoma cells.

Qiang Zhang et al.

Food & function, 6(5), 1518-1525 (2015-03-31)

Flavonoids have been reported to exhibit prooxidant cytotoxicity against cancer cells, but the underlying mechanism is still poorly understood. Here we investigated the potential mechanism that p53-inducible gene 3 (PIG3), a NADPH:quinone oxidoreductase, mediated the prooxidant cytotoxicity of flavonoids on

Perturbations in fatty acid metabolism and apoptosis are manifested in calcific coronary artery disease: An exploratory lipidomic study.

Panagiotis A Vorkas et al.

International journal of cardiology, 197, 192-199 (2015-07-05)

Controversy exists concerning the beneficial or harmful effects of the presence of ectopic calcification in the coronary arteries. Additionally, further elucidation of the exact pathophysiological mechanism is needed. In this study, we sought to identify metabolic markers of vascular calcification

The impact of two different inspiratory to expiratory ratios (1:1 and 1:2) on respiratory mechanics and oxygenation during volume-controlled ventilation in robot-assisted laparoscopic radical prostatectomy: a randomized controlled trial.

Min-Soo Kim et al.

Canadian journal of anaesthesia = Journal canadien d'anesthesie, 62(9), 979-987 (2015-04-15)

Volume-controlled ventilation with a prolonged inspiratory to expiratory ratio (I:E ratio) has been used to optimize gas exchange and respiratory mechanics in various surgical settings. We hypothesized that, when compared with an I:E ratio of 1:2, a prolonged I:E ratio

Labeling phospholipid membranes with lipid mimetic luminescent metal complexes.

Adam Mechler et al.

Biochimica et biophysica acta, 1838(11), 2939-2946 (2014-08-17)

Lipid-mimetic metallosurfactant based luminophores are promising candidates for labeling phospholipid membranes without altering their biophysical characteristics. The metallosurfactants studied exhibit high structural and physicochemical similarity to phospholipid molecules, designed to incorporate into the membrane structure without the need for covalent

Systematic analysis of intracellular trafficking motifs located within the cytoplasmic domain of simian immunodeficiency virus glycoprotein gp41.

Thomas S Postler et al.

PloS one, 9(12), e114753-e114753 (2014-12-06)

Previous studies have shown that truncation of the cytoplasmic-domain sequences of the simian immunodeficiency virus (SIV) envelope glycoprotein (Env) just prior to a potential intracellular-trafficking signal of the sequence YIHF can strongly increase Env protein expression on the cell surface

Transforming growth factor-beta 3 alters intestinal smooth muscle function: implications for gastroschisis-related intestinal dysfunction.

S D Moore-Olufemi et al.

Digestive diseases and sciences, 60(5), 1206-1214 (2014-11-29)

Gastroschisis (GS) is a congenital abdominal wall defect that results in the development of GS-related intestinal dysfunction (GRID). Transforming growth factor-β, a pro-inflammatory cytokine, has been shown to cause organ dysfunction through alterations in vascular and airway smooth muscle. The

Study of penetration behavior of PCB-DNAPL in a sand layer by a column experiment.

Nobuyasu Okuda et al.

Chemosphere, 114, 59-68 (2014-08-13)

To better understand the infiltration performances of high concentration PCB oils (KC-300 and KC-1000 polychlorinated biphenyl (PCB) mixtures), representative dense non-aqueous phase liquid (DNAPL), under both saturated and unsaturated conditions, we conducted experiments on a sand column filled with Toyoura

Influence of E. coli-induced prostatic inflammation on expression of androgen-responsive genes and transforming growth factor beta 1 cascade genes in rats.

Yasuhito Funahashi et al.

The Prostate, 75(4), 381-389 (2014-12-03)

Prostatic inflammation is reportedly associated with the development of prostatic hyperplasia. We investigated the effects of prostatic inflammation on expression levels of androgen-responsive genes and growth factors in the rat prostate. Prostatic inflammation was induced by Escherichia coli (strain 1677)

Chlorogenic acid enhances the effects of 5-fluorouracil in human hepatocellular carcinoma cells through the inhibition of extracellular signal-regulated kinases.

Yuan Yan et al.

Anti-cancer drugs, 26(5), 540-546 (2015-02-26)

There is an urgent need to search for novel chemosensitizers in the field of cancer therapy. Chlorogenic acid (CGA), a type of polyphenol present in the diet, has many biological activities. The present study is designed to explore the influence

Refluxing synthesis, photoluminescence and binding ability to deoxyribonucleic acid of water-soluble rare earth ion-doped LaF3 nanoparticles.

Zhenling Wang et al.

Journal of nanoscience and nanotechnology, 14(6), 4506-4512 (2014-04-18)

Water-soluble rare earth ion (Ce3+, Tb3+)-doped LaF3 nanoparticles with the ability to bind to deoxyribonucleic acid (DNA) were prepared by the refluxing method in a glycerol/water mixture and characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), photoluminescence (PL) spectra

Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development.

Qian Wang et al.

The Journal of pathology, 236(3), 278-289 (2015-02-20)

Glutamine is conditionally essential in cancer cells, being utilized as a carbon and nitrogen source for macromolecule production, as well as for anaplerotic reactions fuelling the tricarboxylic acid (TCA) cycle. In this study, we demonstrated that the glutamine transporter ASCT2

Development and Validation of a High-Throughput Ultrahigh-Performance Liquid Chromatography-Mass Spectrometry Approach for Screening of Oxylipins and Their Precursors.

Arnaud M Wolfer et al.

Analytical chemistry, 87(23), 11721-11731 (2015-10-27)

Lipid mediators, highly bioactive compounds synthesized from polyunsaturated fatty acids (PUFAs), have a fundamental role in the initiation and signaling of the inflammatory response. Although extensively studied in isolation, only a limited number of analytical methods offer a comprehensive coverage

Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia.

Thomas P Hellyer et al.

Thorax, 70(1), 41-47 (2014-10-10)

Excessive use of empirical antibiotics is common in critically ill patients. Rapid biomarker-based exclusion of infection may improve antibiotic stewardship in ventilator-acquired pneumonia (VAP). However, successful validation of the usefulness of potential markers in this setting is exceptionally rare. We

Low-temperature preparation of functional carbon nanocapsules via self-assembly and carbonization of hexayne amphiphiles.

Stephen Schrettl et al.

Chimia, 67(6), 429-429 (2013-08-16)

Population growth rate and genetic variability of small and large populations of Red flour beetle (Tribolium castaneum) following multigenerational exposure to copper.

Ryszard Laskowski et al.

Ecotoxicology (London, England), 24(5), 1162-1170 (2015-04-30)

We reared large (1000 individuals) and small (20 individuals) populations of Tribolium castaneum on diet contaminated with copper in order to determine if the size of a population affects its ability to adapt to adverse environmental conditions. After 10 generations

Does water-jet force make a difference in fat grafting? In vitro and in vivo evidence of improved lipoaspirate viability and fat graft survival.

Shilu Yin et al.

Plastic and reconstructive surgery, 135(1), 127-138 (2014-10-07)

Recent literature has revealed that water-jet-assisted liposuction offers a new method of conventional liposuction techniques by using the gentle spray of fluid. However, there has not yet been a systematic, randomized, controlled study to demonstrate its effect on the vitality

Identification and characterization of a novel citrate synthase from Streptomyces diastaticus No. 7 strain M1033.

Yadong Ge et al.

Biotechnology and applied biochemistry, 62(3), 300-308 (2015-03-19)

Citrate synthase (CS) is a key enzyme of the tricarboxylic acid cycle and is widely distributed among prokaryotes and eukaryotes. Here, we report for the first time, the cloning, expression, and characterization of a novel CS from Streptomyces diastaticus No.

Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid.

Julia Spengler et al.

Arthritis & rheumatology (Hoboken, N.J.), 67(12), 3135-3145 (2015-08-08)

In the majority of patients with rheumatoid arthritis (RA), antibodies specifically recognize citrullinated autoantigens that are generated by peptidylarginine deiminases (PADs). Neutrophils express high levels of PAD and accumulate in the synovial fluid (SF) of RA patients during disease flares.

Structural, thermal, and anti-inflammatory properties of a novel pectic polysaccharide from alfalfa (Medicago sativa L.) stem.

Lei Chen et al.

Journal of agricultural and food chemistry, 63(12), 3219-3228 (2015-03-11)

A pectic polysaccharide (APPS) was purified from the cold alkali extract of alfalfa stem and characterized to be a rhamnogalacturonan I (RG-I) type pectin with the molecular weight of 2.38 × 10(3) kDa and a radius of 123 nm. The

Time-lapse Raman imaging of osteoblast differentiation.

Aya Hashimoto et al.

Scientific reports, 5, 12529-12529 (2015-07-28)

Osteoblastic mineralization occurs during the early stages of bone formation. During this mineralization, hydroxyapatite (HA), a major component of bone, is synthesized, generating hard tissue. Many of the mechanisms driving biomineralization remain unclear because the traditional biochemical assays used to

In situ generation of hydroxyl radical by cobalt oxide supported porous carbon enhance removal of refractory organics in tannery dyeing wastewater.

S Karthikeyan et al.

Journal of colloid and interface science, 448, 163-174 (2015-03-04)

In this study, cobalt oxide doped nanoporous activated carbon (Co-NPAC) was synthesized and used as a heterogeneous catalyst for the Fenton oxidation of organic dye chemicals used in tannery process. The nanoporous activated carbon (NPAC) was prepared from rice husk

Anti-carbamylated protein antibodies are present prior to rheumatoid arthritis and are associated with its future diagnosis.

Ryan W Gan et al.

The Journal of rheumatology, 42(4), 572-579 (2015-01-17)

Anti-carbamylated protein (anti-CarP) antibodies could further elucidate early rheumatoid arthritis (RA) pathogenesis and predict clinical disease. We compared the diagnostic accuracy of anti-CarP antibodies for future RA to other RA-related antibodies in military personnel. Stored pre-RA diagnosis serum samples from

Single-domain antibodies targeting neuraminidase protect against an H5N1 influenza virus challenge.

Francisco Miguel Cardoso et al.

Journal of virology, 88(15), 8278-8296 (2014-05-16)

Influenza virus neuraminidase (NA) is an interesting target of small-molecule antiviral drugs. We isolated a set of H5N1 NA-specific single-domain antibodies (N1-VHHm) and evaluated their in vitro and in vivo antiviral potential. Two of them inhibited the NA activity and

Room-temperature ionic liquids enhanced green synthesis of β-glycosyl 1-ester.

Yanli Cui et al.

Carbohydrate research, 407, 51-54 (2015-02-24)

We herein report an efficient synthesis of β-glycosyl 1-ester in room-temperature ionic liquids (RTILs) promoted via silver salt and quaternary ammonium salt (PTC) with good or excellent yields. All products were isolated exclusively as the β-anomers. Four different RTILs, eight

Impaired Telomere Maintenance and Decreased Canonical WNT Signaling but Normal Ribosome Biogenesis in Induced Pluripotent Stem Cells from X-Linked Dyskeratosis Congenita Patients.

Bai-Wei Gu et al.

PloS one, 10(5), e0127414-e0127414 (2015-05-21)

Dyskeratosis congenita (DC) is an inherited bone marrow failure syndrome characterized by the presence of short telomeres at presentation. Mutations in ten different genes, whose products are involved in the telomere maintenance pathway, have been shown to cause DC. The

Ecological feedbacks. Termite mounds can increase the robustness of dryland ecosystems to climatic change.

Juan A Bonachela et al.

Science (New York, N.Y.), 347(6222), 651-655 (2015-02-07)

Self-organized spatial vegetation patterning is widespread and has been described using models of scale-dependent feedback between plants and water on homogeneous substrates. As rainfall decreases, these models yield a characteristic sequence of patterns with increasingly sparse vegetation, followed by sudden

Sustained lung inflation at birth for preterm infants: a randomized clinical trial.

Gianluca Lista et al.

Pediatrics, 135(2), e457-e464 (2015-01-28)

Studies suggest that giving newly born preterm infants sustained lung inflation (SLI) may decrease their need for mechanical ventilation (MV) and improve their respiratory outcomes. We randomly assigned infants born at 25 weeks 0 days to 28 weeks 6 days

Characterization of Clostridium perfringens TpeL toxin gene carriage, production, cytotoxic contributions, and trypsin sensitivity.

Jianming Chen et al.

Infection and immunity, 83(6), 2369-2381 (2015-04-01)

Large clostridial toxins (LCTs) are produced by at least four pathogenic clostridial species, and several LCTs are proven pivotal virulence factors for both human and veterinary diseases. TpeL is a recently identified LCT produced by Clostridium perfringens that has received

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