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Iwona Ziemecka et al.
Lab on a chip, 15(2), 504-511 (2014-11-20)
Pervaporation in a microfluidic device is performed on liquid ternary solutions of hydrogen peroxide-water-methanol in order to concentrate hydrogen peroxide (H2O2) by removing methanol. The quantitative analysis of the pervaporation of solutions with different initial compositions is performed, varying the
Rebecca Klar et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(19), 7600-7615 (2015-05-15)
Of the eight metabotropic glutamate (mGlu) receptor subtypes, only mGlu7 is expressed presynaptically at the Schaffer collateral (SC)-CA1 synapse in the hippocampus in adult animals. Coupled with the inhibitory effects of Group III mGlu receptor agonists on transmission at this
Curtis D Pollman et al.
Bulletin of environmental contamination and toxicology, 93(5), 509-516 (2014-09-28)
The Everglades, an ecosystem of international significance, has elevated biota mercury levels representing risk to human and wildlife consumers of fish. Given the critical role of sulfate in the methylation of mercury, and because there is a significant agricultural contribution
Long Ding et al.
Molecular medicine reports, 11(6), 4431-4437 (2015-01-31)
Bile acids, which are synthesized from cholesterol in the hepatocytes of the liver, are amphipathic molecules with a steroid backbone. Studies have shown that bile acid exhibits important effects on liver regeneration. However, the mechanism underlying these effects remains unclear.
Stefan Wagner et al.
Bioorganic & medicinal chemistry, 23(12), 2839-2847 (2015-04-25)
Phosphopeptide mimetics containing the 4-phosphonocarbonyl phenylalanine (pcF) as a photo-active phosphotyrosine isoster are developed as potent, light-switchable inhibitors of the protein tyrosine phosphatase PTP1B. The photo-active inhibitors 6-10 are derived from phosphopeptide substrates and are prepared from the suitably protected
Shelly R H Pecorella et al.
American journal of physiology. Lung cellular and molecular physiology, 309(8), L857-L871 (2015-07-19)
The heme oxygenase-1 (HO-1)/carbon monoxide (CO) system induces mitochondrial biogenesis, but its biological impact in human skeletal muscle is uncertain. The enzyme system generates CO, which stimulates mitochondrial proliferation in normal muscle. Here we examined whether CO breathing can be
Mengjuan Hua et al.
Analytica chimica acta, 888, 173-181 (2015-09-01)
We herein proposed a simple and effective strategy for preparing graphene quantum dots (GQDs)-based core-satellite hybrid spheres and further explored the feasibility of using such spheres as the ratiometric fluorescence probe for the visual determination of Hg(2+). The red-emitting CdTe
Annika Osswald et al.
PloS one, 10(6), e0128802-e0128802 (2015-06-19)
Health-promoting effects have been attributed to a number of Bifidobacterium sp. strains. These effects as well as the ability to colonise the host depend on secreted proteins. Moreover, rational design of protein secretion systems bears the potential for the generation
Simone Z Vogel et al.
Journal of immunology (Baltimore, Md. : 1950), 194(7), 3136-3146 (2015-03-10)
We previously showed that the T cell activation inhibitor, mitochondrial (Tcaim) is highly expressed in grafts of tolerance-developing transplant recipients and that the encoded protein is localized within mitochondria. In this study, we show that CD11c(+) dendritic cells (DCs), as
Ying Gong et al.
Journal of biomaterials applications, 30(2), 201-211 (2015-03-15)
Magnetic, luminescent, and thermoresponsive multifunctional nanospheres composed of modified Fe3O4 nanoparticles as the core and rare earth complex Tb(AA)3Phen as the shell are synthesized by emulsifier-free emulsion polymerization. The core-shell spherical structure has a size between 140 and 220 nm and
Simon Kaja et al.
Experimental eye research, 138, 159-166 (2015-06-07)
Optic nerve head astrocytes (ONHAs) are the major glia cell type in the non-myelinated optic nerve head where they contribute critically to extracellular matrix synthesis during development and throughout life. In glaucoma, and in related disorders affecting the optic nerve
Obstetrics and gynecology, 123(4), 912-915 (2014-05-03)
Immersion in water has been suggested as a beneficial alternative for labor, or delivery, or both and over the past decades has gained popularity in many parts of world. Immersion in water during the first stage of labor may be
Minoru Miyazato et al.
The Journal of urology, 194(3), 842-847 (2015-03-26)
We investigated the effect of duloxetine, a norepinephrine and serotonin reuptake inhibitor, on the sneeze induced continence reflex and on bladder function in rats with cerebral infarction. Using urethane anesthesia the effect of duloxetine (1 mg/kg intravenously) on the amplitude
Nguyen Minh Duc et al.
Journal of the American Society for Mass Spectrometry, 26(5), 808-817 (2015-03-06)
G protein-coupled receptors (GPCRs) have important roles in physiology and pathology, and 40% of drugs currently on the market target GPCRs for the treatment of various diseases. Because of their therapeutic importance, the structural mechanism of GPCR signaling is of
Marzena Medrek et al.
Acta poloniae pharmaceutica, 70(4), 659-665 (2013-08-08)
The fullerene C60 has chemical properties which seem to predestinate it to be effective transporter of drugs in biological system. To prove this, the DFT/B3LYP (6-31G*) calculations were performed especially in order to determine the structures and energies of the
William A Comrie et al.
The Journal of cell biology, 208(4), 457-473 (2015-02-11)
Integrity of the dendritic cell (DC) actin cytoskeleton is essential for T cell priming, but the underlying mechanisms are poorly understood. We show that the DC F-actin network regulates the lateral mobility of intracellular cell adhesion molecule 1 (ICAM-1), but
Harun Ciftci et al.
Journal of AOAC International, 96(4), 875-879 (2013-09-05)
An analytical method for the preconcentration of nickel (Ni) and lead (Pb) in water samples on polystyrene-graft-ethylmethacrylate copolymer resin has been developed. The determinations of metal ions were performed by flame atomic absorption spectrometry. The experimental parameters, such as solution
Jenni Heidi Eveliina Mäki-Jouppila et al.
Molecular oncology, 9(6), 1056-1070 (2015-02-17)
The let-7 microRNA (miRNA) family has been implicated in the regulation of diverse cellular processes and disease pathogenesis. In cancer, loss-of-function of let-7 miRNAs has been linked to tumorigenesis via increased expression of target oncogenes. Excessive proliferation rate of tumor
Shadab Faramarzi et al.
Plant foods for human nutrition (Dordrecht, Netherlands), 70(3), 324-330 (2015-07-03)
In order to promote breeding programs and a full reintroduction into production of two local red-fleshed apple varieties grown in Bekran and Bastam (Iran), the evaluation of their antioxidant properties was of interest. LC-MS(n) based metabolic fingerprinting analyses were applied
Andrew M Novick et al.
Neuropharmacology, 97, 194-200 (2015-06-10)
Being bullied during adolescence is associated with later mental illnesses characterized by deficits in cognitive tasks mediated by prefrontal cortex (PFC) dopamine (DA). Social defeat of adolescent male rats, as a model of teenage bullying victimization, results in medial PFC
Xuesong Guo et al.
Journal of environmental sciences (China), 25(4), 645-651 (2013-08-09)
In the Orbal oxidation ditch, denitrification is primarily accomplished in the outer channel. However, the detailed characteristics of the flow field and dissolved oxygen (DO) distribution in the outer channel are not well understood. Therefore, in this study, the flow
Richard J Flannery et al.
American journal of physiology. Renal physiology, 309(8), F697-F707 (2015-08-21)
Defects in primary cilia lead to a variety of human diseases. One of these, polycystic kidney disease, can be caused by defects in a Ca²⁺-gated ion channel (TRPP2) found on the cilium. Other ciliary functions also contribute to cystogenesis, and
Diana Adliene et al.
Radiation protection dosimetry, 165(1-4), 406-409 (2015-03-31)
Evaluation of the new lead-free optically transparent nanocomposites is provided in this paper along with the introduction to their fabrication technologies and the results of investigation of their X-ray attenuating and optical properties before and after their exposure to high
Agriculture: State-of-the-art soil.
Rachel Cernansky
Nature, 517(7534), 258-260 (2015-01-17)
Eva Herzog et al.
Anesthesiology, 122(2), 387-398 (2014-11-25)
Edoxaban is an oral, selective direct factor Xa inhibitor approved in Japan for venous thromboembolism prevention after orthopedic surgery. Data are lacking regarding reversal strategies for edoxaban; this study assessed whether four-factor prothrombin complex concentrate (Beriplex/Kcentra; CSL Behring GmbH, Marburg
Daniel J O'Sullivan et al.
BMC microbiology, 15, 266-266 (2015-11-19)
The aim of this study was to employ high-throughput DNA sequencing to assess the incidence of bacteria with biogenic amine (BA; histamine and tyramine) producing potential from among 10 different cheeses varieties. To facilitate this, a diagnostic approach using degenerate
Mary A Rodgers et al.
The Journal of experimental medicine, 211(7), 1333-1347 (2014-06-25)
Linear ubiquitination is a newly discovered posttranslational modification that is currently restricted to a small number of known protein substrates. The linear ubiquitination assembly complex (LUBAC), consisting of HOIL-1L, HOIP, and Sharpin, has been reported to activate NF-κB-mediated transcription in
Laure-Anais Vincent et al.
Fundamental & clinical pharmacology, 29(2), 164-177 (2015-01-21)
On account of its strong ability to become chemoresistant after a primary response to drugs, malignant melanoma (MM) remains a therapeutic challenge. This study focuses on acquired resistance to vinca alkaloids (VAs) using VA-resistant MM cell lines (CAL1R-VCR, CAL1R-VDS, and
Yunqing Tang et al.
Scientific reports, 5, 11073-11073 (2015-06-23)
Single molecule localization based super-resolution fluorescence microscopy offers significantly higher spatial resolution than predicted by Abbe's resolution limit for far field optical microscopy. Such super-resolution images are reconstructed from wide-field or total internal reflection single molecule fluorescence recordings. Discrimination between
Francisco J Rios et al.
The Journal of pharmacology and experimental therapeutics, 353(1), 27-34 (2015-01-27)
Hyperaldosteronism and hypertension were unexpected side effects observed in trials of torcetrapib, a cholesteryl ester-transfer protein (CETP) inhibitor that increases high-density lipoprotein. Given that CETP inhibitors are lipid soluble, accumulate in adipose tissue, and have binding sites for proteins involved
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