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Priyanka Saxena et al.
Indian journal of experimental biology, 52(8), 793-798 (2014-08-22)
With an aim to devise a prophylactic and/or therapeutic approach for preventing internalization of radiothallium (201Tl), and more importantly by implication, its chemical analogue radiocesium (137Cs) during any nuclear emergency, different ex vivo and in vivo animal models were created
María C Merino et al.
PLoS neglected tropical diseases, 8(7), e2997-e2997 (2014-07-25)
Protein S-palmitoylation, a hydrophobic post-translational modification, is performed by protein acyltransferases that have a common DHHC Cys-rich domain (DHHC proteins), and provides a regulatory switch for protein membrane association. In this work, we analyzed the presence of DHHC proteins in
Yasuhiro Nakagami et al.
British journal of pharmacology, 172(5), 1237-1249 (2014-11-05)
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that binds to antioxidant response elements located in the promoter region of genes encoding many antioxidant enzymes and phase II detoxifying enzymes. Activation of the Nrf2 pathway seems
Sarang Dilip Pophaly et al.
Microbial cell factories, 11, 114-114 (2012-08-28)
Lactic acid bacteria (LAB) have taken centre stage in perspectives of modern fermented food industry and probiotic based therapeutics. These bacteria encounter various stress conditions during industrial processing or in the gastrointestinal environment. Such conditions are overcome by complex molecular
Zhi Li et al.
Journal of photochemistry and photobiology. B, Biology, 149, 51-57 (2015-06-06)
Fullerene (C60) L-phenylalanine derivative attached with poly (lactic acid) (C60-phe-PLA) was developed to prepare injectable Mitoxantrone (MTX) multifunctional implants. C60-phe-PLA was self-assembled to form microspheres consisting of a hydrophilic antitumor drug (MTX) and a hydrophobic block (C60) by dispersion-solvent diffusion
Andrea Felser et al.
Toxicology, 324, 136-146 (2014-08-12)
Benzbromarone is an uricosuric structurally related to amiodarone and a known mitochondrial toxicant. The aim of the current study was to improve our understanding in the molecular mechanisms of benzbromarone-associated hepatic mitochondrial toxicity. In HepG2 cells and primary human hepatocytes
Naomi L Kruhlak et al.
Toxicology mechanisms and methods, 18(2-3), 217-227 (2008-01-01)
ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifested in preclinical studies and may delay or prevent the development
N S Oh et al.
Journal of dairy science, 98(8), 5102-5112 (2015-05-26)
This study examined the effects of Maillard reaction products (MRP) and MRP fermented by lactic acid bacteria on antioxidants and their enhancement of cardiovascular health in ICR mouse and rat models. In previous in vitro studies, the selected lactic acid
Weiwei Li et al.
International journal of clinical and experimental pathology, 8(6), 7022-7027 (2015-08-12)
To investigate the mitochondrial mutations in patients suffering from both mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) and maternally inherited diabetes. MELAS was confirmed by muscle biopsy performed from the biceps muscle of the proband. Mitochondrial DNA (mtDNA)
Jianyong Sheng et al.
ACS applied materials & interfaces, 7(28), 15430-15441 (2015-06-26)
Although several strategies have been applied for oral insulin delivery to improve insulin bioavailability, little success has been achieved. To overcome multiple barriers to oral insulin absorption simultaneously, insulin-loaded N-trimethyl chitosan chloride (TMC)-coated polylactide-co-glycoside (PLGA) nanoparticles (Ins TMC-PLGA NPs) were
Lactic acidosis.
Ibidumo Igah et al.
The New England journal of medicine, 372(11), 1077-1077 (2015-03-12)
Oscar Manuel Portilla Rivera et al.
Applied biochemistry and biotechnology, 177(5), 1099-1114 (2015-08-22)
The increasing amounts of residual cellulose films generated as wastes all over the world represent a big scale problem for the meat industry regarding to environmental and economic issues. The use of residual cellulose films as a feedstock of glucose-containing
Alexandra Deviers et al.
International journal of radiation oncology, biology, physics, 90(2), 385-393 (2014-08-12)
Because lactate accumulation is considered a surrogate for hypoxia and tumor radiation resistance, we studied the spatial distribution of the lactate-to-N-acetyl-aspartate ratio (LNR) before radiation therapy (RT) with 3D proton magnetic resonance spectroscopic imaging (3D-(1)H-MRSI) and assessed its impact on
Beatriz M Souza et al.
Caries research, 49(5), 499-507 (2015-08-19)
This study evaluated the effect of an experimental paste containing hydroxyapatite in nanoparticles (nano-HA)/fluoride on dental de-remineralisation in situ. Thirteen subjects took part in this crossover/randomised/double-blind study performed in 4 phases (14 days each). Four sound and 4 pre-demineralised specimens
Perplexity of a fungus in the sinus.
Radhika Dasararaju et al.
The American journal of medicine, 127(1), e1-e2 (2013-11-26)
Xiang Li et al.
The Analyst, 140(23), 7918-7925 (2015-10-27)
Sensitive and selective detection of ultralow concentrations of specific biomolecules is important in early clinical diagnoses and biomedical applications. Many types of aptasensors have been developed for the detection of various biomolecules, but usually suffer from false positive signals and
G Oldenbeuving et al.
Anaesthesia and intensive care, 42(4), 507-511 (2014-06-27)
Lactate can substitute for glucose as a metabolic substrate. We report a patient with acute liver failure who was awake despite a glucose level of 0.7 mmol/l with very high lactate level of 25 mmol/l. The hypoglycaemia+hyperlactataemia combination may be
Serum lactate increase during acute asthma treatment: a new piece of the puzzle.
Gustavo J Rodrigo
Chest, 145(1), 6-7 (2014-01-08)
Ling Gu et al.
BMC cancer, 15, 529-529 (2015-07-21)
Increasing evidence indicates that rapamycin could be used as a potential glucocorticoid (GC) sensitizer in lymphoblastic malignancies via genetic prevention of 4E-BP1 phosphorylation. Interestingly, we found that combined rapamycin with dexamethasone can effectively reverse GC resistance in 4E-BP1 null lymphoma
Xinchun Lin et al.
Critical care medicine, 43(6), e160-e169 (2015-03-19)
Administration of NaHCO3 does not improve cellular function or reduce the mortality of acute lactic acidosis. This might be related to aggravation of intracellular acidosis, but it could also be due to activation of Na+/H+ exchanger with a deleterious increment
X Lin et al.
Oral diseases, 21(1), e128-e134 (2014-05-09)
To compare the effects of five probiotic lactobacilli strains on the growth and biofilm formation of Streptococcus mutans (MS). Five probiotic lactobacilli bacteria (LB), Lactobacillus casei Shirota, Lactobacillus casei LC01, Lactobacillus plantarum ST-III, Lactobacillus paracasei Lpc-37, and Lactobacillus rhamnosus HN001
Fei Yu et al.
International journal of oral science, 7(3), 179-186 (2015-01-31)
Titanium and its alloys are routinely used as biomedical implants and are usually considered to be corrosion resistant under physiological conditions. However, during inflammation, chemical modifications of the peri-implant environment including acidification occur. In addition certain biomolecules including lipopolysaccharide (LPS)
Elaine Patterson et al.
Microbiology (Reading, England), 161(Pt 1), 182-193 (2014-11-06)
There is a growing appreciation that microbiota composition can significantly affect host health and play a role in disease onset and progression. This study assessed the impact of streptozotocin (STZ)-induced type-1-diabetes (T1D) on intestinal microbiota composition and diversity in Sprague-Dawley
Antonia Nostro et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 122(7), 648-653 (2013-12-11)
Staphylococcal growth and biofilm formation in culture medium where pH was lowered with weak organic (acetic and lactic) or strong inorganic (hydrochloric) acids were studied. The effects were evaluated by biomass measurements, cell-surface hydrophobicity, scanning electron microscopy (SEM), and confocal
Amish Shah et al.
The American journal of emergency medicine, 32(7), 752-755 (2014-05-13)
Gastrointestinal hemorrhage (GIH) is a common complaint seen in the emergency department (ED) and carries a small but significant mortality rate. The principal purpose of this investigation was to determine whether an ED venous lactate as part of initial laboratory
K T Shalumon et al.
Journal of biomedical nanotechnology, 9(12), 2117-2122 (2013-11-26)
This work explains the fabrication and potential applicability of high thick three dimensional (3-D) electrospun multiscale fibrous scaffolds in tissue engineering by focusing on the possible fabrication techniques. Multiscale fibrous scaffold of poly(lactic acid) (PLA) was fabricated by combining nano
William Hubbard et al.
The Journal of surgical research, 193(1), 355-360 (2014-08-03)
From 2001-2011, >80% of potentially survivable United States battlefield deaths were due to severe hemorrhage. We subjected male rats to acute severe blood loss, administered a single dose of 17α-ethynylestradiol-3-sulfate (EE-3-SO4) without resuscitative fluids, and measured survival and also mean
Zhengfei Yang et al.
The American journal of emergency medicine, 32(1), 50-54 (2013-11-12)
The latest guidelines both increased the requirements of chest compression rate and depth during cardiopulmonary resuscitation (CPR), which may make it more difficult for the rescuer to provide high-quality chest compression. In this study, we investigated the quality of chest
Burcu Kördikanlıoğlu et al.
Biotechnology progress, 31(3), 678-685 (2015-04-01)
In this study, nisin production of Lactococcus lactis N8 was optimized by independent variables of glucose, hemin and oxygen concentrations in fed-batch fermentation in which respiration of cells was stimulated with hemin. Response surface model was able to explain the
Tao Luo et al.
Reproductive toxicology (Elmsford, N.Y.), 51, 14-21 (2014-12-03)
Emodin, a bioactive anthraquinone widely used in Chinese traditional medicine, disrupts mouse testicular gene expression in vivo. In this study, we investigated the toxicity of emodin to human sperm in vitro. Different doses of emodin (25, 50, 100, 200 and
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