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Mònica Rosa et al.
Journal of proteome research, 14(8), 3162-3173 (2015-06-20)
Human μ-opioid receptor (hMOR) is a class-A G-protein-coupled receptor (GPCR), a prime therapeutic target for the management of moderate and severe pain. A chimeric form of the receptor has been cocrystallized with an opioid antagonist and resolved by X-ray diffraction;
Xia Tao et al.
The International journal of artificial organs, 37(7), 529-538 (2014-07-22)
Microbial contamination is often present in dialysate used for hemodialysis. Small single-stranded bacterial DNA sequences are capable of activating human inflammatory pathways, through mechanisms that include the Toll-like-receptor 9, and dialysis patients frequently show severe inflammation. Since these molecules have
J Yang et al.
Transplantation proceedings, 46(10), 3282-3288 (2014-12-17)
Hepatic ischemic/reperfusion injury (HIRI) is a major complication of liver resection and transplantation. Octreotide, a somatostatin analogue, has been used to treat hepatic fibrosis and portal hypertension; however, its function against HIRI remains unclear. To elucidate the effect of octreotide
Sarah Zanon Agapito-Tenfen et al.
BMC plant biology, 14, 346-346 (2014-12-11)
The safe use of stacked transgenic crops in agriculture requires their environmental and health risk assessment, through which unintended adverse effects are examined prior to their release in the environment. Molecular profiling techniques can be considered useful tools to address
Yanhua Huang et al.
Analytica chimica acta, 877, 90-99 (2015-05-24)
Four kinds of green deep eutectic solvents (DESs) based on choline chloride (ChCl) have been synthesized and coated on the surface of magnetic graphene oxide (Fe3O4@GO) to form Fe3O4@GO-DES for the magnetic solid-phase extraction of protein. X-ray diffraction (XRD), vibrating
Robert M Sears et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(50), 20260-20265 (2013-11-28)
Survival in a dangerous environment requires learning about stimuli that predict harm. Although recent work has focused on the amygdala as the locus of aversive memory formation, the hypothalamus has long been implicated in emotional regulation, and the hypothalamic neuropeptide
Yuqin Li et al.
Bioresource technology, 192, 781-791 (2014-08-16)
Proteomics in conjunction with biochemical strategy was employed to unravel regulation of lipid metabolism in the green microalga Chlorella protothecoides by heterotrophy-photoinduction cultivation regime (HPC). Interestingly, HPC triggered transiently synthesis of starch followed by substantial lipid accumulation. And a marked
J T Richeson et al.
Journal of animal science, 93(8), 4089-4097 (2015-10-07)
Growth implant efficacy may be affected when administered to nutritionally stressed calves, whereas the procedure may alter health or the humoral immune response to respiratory vaccination. The study objective was to determine the effect of different administration times (d 0
Yongyao Fu et al.
Journal of Alzheimer's disease : JAD, 47(4), 915-926 (2015-09-25)
Alzheimer's disease (AD) is the most common cause of dementia. Mice in the transgenic AβPPswe/PS1dE9 mouse line express a chimeric mouse/human amyloid-β protein precursor (Mo/HuAβPP695swe) and mutant human presenilin 1 (PS1-dE9) associated with early-onset AD. Knowing the protein expression in
Luisa Pieroni et al.
Molecular bioSystems, 11(6), 1633-1643 (2015-04-08)
The exposure of blood to an artificial surface such as the haemodialysis membrane results in the nearly instantaneous deposition of a layer of plasma proteins. The composition of the protein layer profoundly influences all subsequent events, and to a large
Qi Xiong et al.
BioMed research international, 2015, 596789-596789 (2015-06-30)
Estrogen plays an important role in inhibiting osteoclast differentiation and protecting against bone loss from osteoporosis, especially in postmenopausal women. However, the precise mechanisms underlying the effect of estrogen on osteoclasts are not well known. In the present study, we
Nikki van Bel et al.
PloS one, 9(7), e103552-e103552 (2014-07-30)
The viral integrase (IN) is an essential protein for HIV-1 replication. IN inserts the viral dsDNA into the host chromosome, thereby aided by the cellular co-factor LEDGF/p75. Recently a new class of integrase inhibitors was described: allosteric IN inhibitors (ALLINIs).
C Czoski-Murray et al.
Health technology assessment (Winchester, England), 16(50), i-xvi (2013-01-11)
The evidence base which supported the National Institute for Health and Clinical Excellence (NICE) published Clinical Guideline 3 was limited and 50% was graded as amber. However, the use of tests as part of pre-operative work-up remains a low-cost but
João Pc Brito et al.
SpringerPlus, 3, 600-600 (2014-11-14)
The Trichoderma genus consists of a group of free-living filamentous fungi, including species able to act as biological control agents (BCAs) against pathogenic fungi. It is believed that this ability is due to synergy between several mechanisms, including the production
Jingshu Xu et al.
Atherosclerosis, 242(1), 268-276 (2015-08-02)
The cholesterol-fed rabbit is commonly used as a model to study the vascular effects of hypercholesterolemia and resulting atherosclerotic lesions. Here we undertook a proteomic case-control investigation of ascending aortas from male New Zealand White rabbits after 10 weeks on
Phattara-Orn Havanapan et al.
Developmental and comparative immunology, 54(1), 126-136 (2015-09-19)
Yellow head virus (YHV) causes acute infections and mass mortality in black tiger shrimp culture. Our study aims to investigate molecular interaction between YHV and circulating hemocytes of Penaeus monodon at early infection. Total shrimp hemocytes were isolated by Percoll
Noreen Yaqoob et al.
Toxicology, 323, 70-77 (2014-06-14)
Trichloroethylene (TCE) is widely used as a cleaning and decreasing agent and has been shown to cause liver tumours in rodents and a small incidence of renal tubule tumours in male rats. The basis for the renal tubule injury is
Mahmoud M Kamel et al.
Microbial pathogenesis, 77, 31-35 (2014-12-03)
Viral hepatitis is the most significant predisposing factor for hepatocellular carcinoma (HCC). Liver cancer grows silently with mild or no symptoms until the disease is advanced and with little hope of cure. Early recognition of the onset of HCC would
Poppy Datta et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(32), E4400-E4409 (2015-07-29)
Compartmentalization and polarized protein trafficking are essential for many cellular functions. The photoreceptor outer segment (OS) is a sensory compartment specialized for phototransduction, and it shares many features with primary cilia. As expected, mutations disrupting protein trafficking to cilia often
Mathieu Cayla et al.
PLoS pathogens, 10(9), e1004347-e1004347 (2014-09-19)
Protozoan pathogens of the genus Leishmania have evolved unique signaling mechanisms that can sense changes in the host environment and trigger adaptive stage differentiation essential for host cell infection. The signaling mechanisms underlying parasite development remain largely elusive even though
Freimut Schliess et al.
Hepatology (Baltimore, Md.), 60(6), 2040-2051 (2014-03-29)
The impairment of hepatic metabolism due to liver injury has high systemic relevance. However, it is difficult to calculate the impairment of metabolic capacity from a specific pattern of liver damage with conventional techniques. We established an integrated metabolic spatial-temporal
Uta Praekelt et al.
Journal of medical microbiology, 63(Pt 12), 1595-1607 (2014-09-19)
Enteropathogenic Escherichia coli (EPEC) are a major cause of infant diarrhoea in developing countries and a significant public health issue in industrialized countries. Currently there are no simple tests available for the diagnosis of EPEC. Serology of O-antigens is widely
Mei-An Su et al.
PLoS pathogens, 10(6), e1004196-e1004196 (2014-06-20)
In this study, we used a systems biology approach to investigate changes in the proteome and metabolome of shrimp hemocytes infected by the invertebrate virus WSSV (white spot syndrome virus) at the viral genome replication stage (12 hpi) and the
Wilfredo D Mansilla et al.
The Journal of nutrition, 145(6), 1163-1169 (2015-05-01)
Nitrogen absorption from the large intestine is considered of limited value for supporting body protein synthesis in animals and humans, but it may be of benefit when the dietary supply of nitrogen for synthesis of dispensable amino acids (DAAs) is
Verena Paulitschke et al.
Molecular cancer therapeutics, 14(3), 757-768 (2015-01-24)
The FDA-approved BRAF inhibitor vemurafenib achieves outstanding clinical response rates in patients with melanoma, but early resistance is common. Understanding the pathologic mechanisms of drug resistance and identification of effective therapeutic alternatives are key scientific challenges in the melanoma setting.
Maider Martos et al.
European journal of gastroenterology & hepatology, 26(12), 1380-1384 (2014-09-18)
Resistance to antibiotics is the major cause of treatment failure of Helicobacter pylori (HP) infection. The culture-guided triple therapy (chosen on the basis of a preliminary in-vitro susceptibility test) might help to increase treatment success in high antibiotic resistance regions.
Andreas Tebbe et al.
Rapid communications in mass spectrometry : RCM, 29(9), 795-801 (2015-09-18)
Advanced implementations of mass spectrometry (MS)-based proteomics allow for comprehensive proteome expression profiling across many biological samples. The outcome of such studies critically depends on accurate and precise quantification, which has to be ensured for high-coverage proteome analysis possible on
Erin B Taylor et al.
Molecular immunology, 66(2), 126-138 (2015-03-17)
The binding of the lymphocyte specific protein tyrosine kinase (Lck) to T cell co-receptors is required for T cell development and activation. In mammals, Lck initiates signal transduction by binding to CD4 and CD8 co-receptors and phosphorylating ITAMs in the
Susan Yung et al.
Autoimmunity, 48(7), 471-487 (2015-06-24)
Progression to chronic renal failure varies between patients with lupus nephritis. We compared the effects of mycophenolate mofetil (MMF) and cyclophosphamide (CTX), on renal histology and cellular pathways of fibrosis in murine lupus nephritis. Female NZBWF1/J mice were randomized to
Yakov A Lomakin et al.
Molecular immunology, 62(2), 305-314 (2014-02-19)
The mechanisms triggering most of autoimmune diseases are still obscure. Autoreactive B cells play a crucial role in the development of such pathologies and, in particular, production of autoantibodies of different specificities. The combination of deep-sequencing technology with functional studies
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