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Joanna E Kontaraki et al.
Journal of the American Society of Hypertension : JASH, 9(10), 802-810 (2015-09-12)
MicroRNAs regulate several aspects of physiological and pathologic cardiac hypertrophy, and they represent promising therapeutic targets in cardiovascular disease. We assessed the expression levels of the microRNAs miR-1, miR-133a, miR-26b, miR-208b, miR-499, and miR-21, in 102 patients with essential hypertension
Serum uric acid: a risk factor and a target for treatment?
Feig DI, et al.
Journal of the American Society of Nephrology, 17(4), S69-S73 (2006)
A Kępka et al.
Irish journal of medical science, 184(1), 219-225 (2014-03-01)
This study was performed to test the hypothesis that urinary levels of L-carnitine and its derivatives are enhanced in children and adolescents with hypertension and also check if analyzed parameters may serve as early markers of subclinical renal damage. The
B V Morukov et al.
Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine, 47(2), 48-50 (2013-07-03)
In the 520-d chamber experiment within the international project Mars-500 blood samples of 6 male test-subjects of 28 to 39 years of age were analyzed for water-soluble antioxidants: total bilirubin and uric acid; in addition, total antioxidant capacity of blood
Pierre Guermonprez et al.
Nature medicine, 19(6), 730-738 (2013-05-21)
Innate sensing mechanisms trigger a variety of humoral and cellular events that are essential to adaptive immune responses. Here we describe an innate sensing pathway triggered by Plasmodium infection that regulates dendritic cell homeostasis and adaptive immunity through Flt3 ligand
Andreas Oberbach et al.
Metabolism: clinical and experimental, 63(2), 242-249 (2013-12-18)
Serum uric acid (sUA) is believed to contribute to the pathogenesis of metabolic comorbidities like hypertension, insulin-resistance (IR) and endothelial dysfunction (EDF) in obese children. The present pilot study investigated the association between sUA concentrations and loss of body weight
Wenqi Wu et al.
Urology, 83(4), 732-737 (2014-02-04)
To assess urine composition in Chinese patients with urolithiasis. Five hundred seven Chinese patients with urolithiasis from our center in southern China were included in this study. Analysis of stone composition was performed using infrared spectrometry. From all patients, 24-hour
Linda T Tran et al.
Molecular and cellular biochemistry, 392(1-2), 205-211 (2014-04-01)
The purpose of this study was to investigate the effect of chronic treatment with prazosin, a selective α1-adrenoceptor antagonist, on the development of hypertension in fructose-fed rats (FFR). High-fructose feeding and treatment with prazosin (1 mg/kg/day via drinking water) were initiated
Qinfeng Rong et al.
Scientific reports, 5, 11440-11440 (2015-06-16)
In this work, a new network nanocomposite composed of polypyrrole hydrogel (PPy hydrogel) loaded gold nanoparticles (AuNPs) was prepared. The PPy hydrogel was directly synthesized by mixing the pyrrole monomer and phytic acid, and the mixed solution can be gelated
Jingyi Chen et al.
The Analyst, 140(16), 5578-5584 (2015-06-27)
A novel glucose biosensor was developed by immobilizing glucose oxidase (GOD) on a three-dimensional (3D) porous kenaf stem-derived carbon (3D-KSC) which was firstly proposed as a novel supporting material to load biomolecules for electrochemical biosensing. Here, an integrated 3D-KSC electrode
Alex M Lench et al.
Neuropharmacology, 83, 118-127 (2014-04-22)
Presynaptic NMDA receptors facilitate the release of glutamate at excitatory cortical synapses and are involved in regulation of synaptic dynamics and plasticity. At synapses in the entorhinal cortex these receptors are tonically activated and provide a positive feedback modulation of
Kentaro Yano et al.
Journal of pharmaceutical sciences, 104(9), 2789-2794 (2014-12-30)
P-glycoprotein (P-gp) regulates absorption of many drugs in the gastrointestinal tract and their accumulation in tumor tissues, but the basis of substrate recognition by P-gp remains unclear. Bitter-tasting phenylthiocarbamide, which stimulates taste receptor 2 member 38 (T2R38), increases P-gp activity
Roy Fleischmann et al.
Rheumatology (Oxford, England), 53(12), 2167-2174 (2014-02-11)
The aim of this study was to evaluate the pharmacodynamics (PDs), pharmacokinetics (PKs) and safety of lesinurad (selective uric acid reabsorption inhibitor) in combination with febuxostat (xanthine oxidase inhibitor) in patients with gout. This study was a phase IB, multicentre
Hua Zen Ling et al.
European journal of heart failure, 17(1), 35-43 (2014-12-04)
Plasma volume (PV) expansion hallmarks worsening chronic heart failure (CHF) but no non-invasive means of quantifying volume status exists. Because weight and haematocrit are related to PV, they can be used to calculate relative PV status (PVS). We tested the
H Huang et al.
Atherosclerosis, 235(1), 213-222 (2014-05-27)
Deletion of inducible nitric oxide synthase (iNOS) in apolipoprotein E knockout mice was shown to mitigate the extent of arteriosclerosis. Oxidized low density lipoprotein (oxLDL) inhibits macrophage migration and traps foam cells, possibly through a mechanism involving oxidative stress. Here
Kei Fukami et al.
Journal of cardiovascular pharmacology, 65(3), 289-295 (2015-01-31)
Food or supplement-derived L-carnitine is changed to trimethylamine (TMA) by interstinal microbiota, which is further metabolized to trimethylamine-N-oxide (TMAO), being involved in the promotion of atherosclerosis in animal models. Meanwhile, carnitine deficiency has played a role in accelerated atherosclerosis in
Bariatric surgery as urate-lowering therapy in severe obesity.
Hyon K Choi et al.
Annals of the rheumatic diseases, 73(5), 791-793 (2014-04-08)
Periyar Selvam Sellamuthu et al.
Pakistan journal of pharmaceutical sciences, 27(1), 161-167 (2014-01-01)
Salacia chinensis L. is a traditional Southeast Asian herbal medicine and used in the treatment of diabetes. To investigate the antidiabetic properties of mangiferin from Salacia chinensis and its beneficial effect on toxicological and hematological parameters in streptozotocin induced diabetic
Yi-Lun Wang et al.
PloS one, 10(11), e0141079-e0141079 (2015-11-05)
To examine the cross-sectional associations between dietary magnesium (Mg) intake and hyperuricemia (HU). 5168 subjects were included in this study. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire. Hyperuricemia (HU) was defined as uric acid ≥ 416
Reduction of Serum Uric Acid Associated with Attenuation of Renal Injury, Inflammation and Macrophages M1/M2 Ratio in Hyperuricemic Mice Model
HARYONO A, et al.
Kobe J. Med. Sci., 64(3), E107-E114 (2018)
Uric acid in plants and microorganisms: Biological applications and genetics-A review
Hafez RM, et al.
Journal of Advanced Research, 8(5), 475-486 (2017)
Ya Huang et al.
Biotechnology and applied biochemistry, 62(1), 137-144 (2014-03-29)
A new formulation of the bireagent kit for serum uric acid assay was developed based on the effects of pH on enzyme stability. At 4 °C, half-lives of uricases from Bacillus fastidious and Arthrobacter globiforms were longer than 15 months at
Ramón García-Trabanino et al.
Environmental research, 142, 746-755 (2015-07-26)
An epidemic of progressive kidney failure afflicts sugarcane workers in Central America. Repeated high-intensity work in hot environments is a possible cause. To assess heat stress, dehydration, biomarkers of renal function and their possible associations. A secondary aim was to
Jaswinder Pal Singh et al.
The Journal of surgical research, 187(2), 631-639 (2014-01-18)
Gallic acid is a polyphenolic compound and is reported to be renoprotective because of its antioxidant activity in various preclinical studies. Gallic acid has been reported to activate peroxisome proliferator-activated receptor gamma (PPAR-γ) in vitro. However, the relevance of the interplay
Lidia Tomkiewicz-Pajak et al.
Journal of cardiology, 64(5), 384-389 (2014-04-05)
Growing evidence indicates that iron-deficiency anemia is common in patients with congenital heart diseases. The aim of this study was to characterize hematologic changes and iron metabolism in adult Fontan patients. We also searched for the associations between these parameters
[Tumor lysis syndrome].
Kenichi Ishizawa
[Rinsho ketsueki] The Japanese journal of clinical hematology, 54(10), 2006-2013 (2013-09-26)
Julie Clar et al.
Kidney international, 86(4), 747-756 (2014-04-11)
Renal failure is a major complication that arises with aging in glycogen storage disease type 1a and type 1b patients. In the kidneys, glucose-6 phosphatase catalytic subunit (encoded by G6pc) deficiency leads to the accumulation of glycogen, an effect resulting
Pragya Agar Palod et al.
Materials science & engineering. C, Materials for biological applications, 55, 420-430 (2015-06-29)
In this paper a novel enzymatic glucose biosensor has been reported in which platinum coated alumina membranes (Anodisc™s) have been employed as templates for the growth of polypyrrole (PPy) nanotube arrays using electrochemical polymerization. The PPy nanotube arrays were grown
Jayoung Kim et al.
Biosensors & bioelectronics, 74, 1061-1068 (2015-08-16)
This article demonstrates an instrumented mouthguard capable of non-invasively monitoring salivary uric acid (SUA) levels. The enzyme (uricase)-modified screen printed electrode system has been integrated onto a mouthguard platform along with anatomically-miniaturized instrumentation electronics featuring a potentiostat, microcontroller, and a
Niki Katsiki et al.
Current pharmaceutical design, 19(27), 4930-4937 (2013-01-03)
Elevated serum uric acid (SUA) levels (i.e. hyperuricaemia) have been associated with metabolic syndrome (MetS) and cardiovascular disease (CVD) morbidity and mortality. Elevated SUA levels predict the onset of type 2 diabetes (T2DM). SUA levels are increased during the early
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