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Safety and activity of a new intensive short-term chemoimmunotherapy in HIV-positive patients with Burkitt lymphoma.
Andrés J M Ferreri et al.
British journal of haematology, 159(2), 252-255 (2012-08-29)
Nasim Shahidi Hamedani et al.
Nucleic acid therapeutics, 26(6), 355-362 (2016-10-14)
Activated protein C (APC) is a critical regulator of thrombin formation and thereby protects against thrombosis. On the other hand, overwhelming formation of APC increases the risk of bleeding such as in trauma-induced coagulopathy. Thus, pharmacological inhibition of APC activity
Ashish A Prabhu et al.
Molecular biology reports, 45(5), 961-972 (2018-07-19)
In the present study, the effects of individual as well as multiple genes of pentose phosphate pathway (PPP) on human interferon gamma (hIFN-γ) production were analyzed. With overexpression of 6-phosphogluconate dehydrogenase (GND2), 1.9-fold increase in hIFN-γ was achieved, while synergetic
De-Hui Kong et al.
Oncotarget, 7(1), 700-711 (2015-12-02)
Bcl-2 associated athanogene 3 (BAG3) contains multiple protein-binding motifs to mediate potential interactions with chaperons and/or other proteins, which is possibly ascribed to the multifaceted functions assigned to BAG3. The current study demonstrated that BAG3 directly interacted with glucose 6
Kamarulzaman Karim et al.
Systems biology in reproductive medicine, 62(1), 57-68 (2015-12-29)
Changes in the uterus expression of carbonic anhydrase (CA) II, III, IX, XII, and XIII were investigated under the influence of sex-steroids in order to elucidate mechanisms underlying differential effects of these hormones on uterine pH. Uteri of ovariectomised rats
Kubandiran Kolanji et al.
The Journal of organic chemistry, 82(15), 7764-7773 (2017-07-01)
The synthesis of four nitronyl nitroxide (NN) biradicals is described which are conjugatively linked through p-ter-phenyl (PPP), ter-thiophene (TTT) and alternating phenylene (P) and thiophene (T) units as PTP and TPT. We first utilized Suzuki and Stille coupling reactions through
Yingqian Liu et al.
Bioorganic & medicinal chemistry, 20(21), 6285-6295 (2012-10-02)
A series of eight novel podophyllotoxin derivatives were designed, synthesized and evaluated for biological activities. The antiproliferative activities were tested against a panel of human cancer cell lines (K562, SGC, Hela and HepG) and the inhibition of tubulin polymerization was
Wen Qiu et al.
Journal of proteome research, 16(7), 2370-2383 (2017-05-19)
The thermoacidophilic crenarchaeon Sulfolobus solfataricus has been widely used as a model organism for archaeal systems biology research. Investigation using its spontaneous mutant PBL2025 provides an effective metabolic baseline to study subsequent mutagenesis-induced functional process shifts as well as changes
Brenden Jongman et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(18), E2271-E2280 (2015-04-23)
The global impacts of river floods are substantial and rising. Effective adaptation to the increasing risks requires an in-depth understanding of the physical and socioeconomic drivers of risk. Whereas the modeling of flood hazard and exposure has improved greatly, compelling
Xiaosheng Lu et al.
Biochemical and biophysical research communications, 435(3), 385-390 (2013-05-15)
Epithelial ovarian cancer (EOC) is one of the leading causes of gynecological cancer death. Approximately 70% of the patients experience recurrence accompanied by the development of drug resistance 2-3 years after chemotherapy. Picropodophyllin (PPP) is a newly identified insulin-like growth
Oliver Felthaus et al.
Clinical hemorheology and microcirculation, 66(1), 47-55 (2017-03-09)
Autologous fat grafts and adipose-derived stem cells (ASCs) can be used to treat soft tissue defects. However, the results are inconsistent and sometimes comprise tissue resorption and necrosis. This might be due to insufficient vascularization. Platelet-rich plasma (PRP) is a source
Antonio Pizzirusso et al.
Journal of the American Chemical Society, 140(39), 12405-12414 (2018-09-05)
A molecular interpretation of the eutectic behavior of a binary mixture of tristearin (SSS) and tripalmitin (PPP) triglycerides was formulated using computer simulations and experimental techniques (calorimetry and X-ray scattering). A eutectic composition was identified using both experimental and computer
Qing Zhu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 905, 145-149 (2012-09-04)
Ultrahigh pressure extraction (UPE) was employed to extract podophyllotoxin and 4'-demethylpodophyllotoxin from Dysosma versipellis. The effects of extraction parameters including extraction solvents, pressure, time and solid/liquid ratio were investigated using a High Hydrostatic Pressure Processor. The optimal condition for UPE
Chao Wang et al.
Cytotherapy, 21(6), 619-630 (2019-04-09)
Insulin-like growth factor 2 (IGF2), an essential component of the stem cell niche, has been reported to modulate the proliferation and differentiation of stem cells. Previously, a continuous expression of IGF2 in tissues was reported to maintain the self-renewal ability
Carina Levin et al.
Frontiers in physiology, 9, 1214-1214 (2018-09-15)
β-thalassemia major (β-TM) is a therapeutically challenging chronic disease in which ineffective erythropoiesis is a main pathophysiological factor. Extracellular vesicles (EVs) are membrane-enclosed vesicles released by cells into biological fluids; they are involved in intercellular communication and in multiple physiological
Nour Qa'aty et al.
Endocrinology, 156(1), 90-102 (2014-10-30)
Glucagon-like peptide 1 (GLP-1) is a metabolic hormone involved in the stimulation of insulin biosynthesis and secretion. It has been recently reported that GLP-1 also exerts cardioprotective effects and facilitates functional recovery after myocardial infarction through GLP-1 receptor-mediated signaling in
Shan Ma et al.
Experimental eye research, 135, 1-13 (2015-04-19)
Cones are the primary photoreceptor (PR) cells responsible for vision in humans. They are metabolically highly active requiring phosphoinositide 3-kinase (PI3K) activity for long-term survival. One of the downstream targets of PI3K is the kinase mammalian target of rapamycin (mTOR)
The unplanned intraoperative pharyngotomy: Pull, plug, or patch.
Joseph Zenga et al.
The Laryngoscope, 125(12), 2736-2740 (2015-10-10)
B Kevane et al.
Journal of thrombosis and haemostasis : JTH (2018-05-29)
Essentials Eisenmenger syndrome is characterised by thrombotic and hemorrhagic risks of unclear aetiology. Calibrated automated thrombography was used to assess these coagulation derangements. Platelet activity supported abnormalities in procoagulant and anticoagulant pathway function. Endothelin-1 antagonism appeared to ameliorate these derangements.
Tinglan Yuan et al.
Journal of agricultural and food chemistry, 67(8), 2272-2278 (2019-02-02)
Triacylglycerol (TAG) composition of breast milk plays an important role in improving digestion, absorption, and metabolism when consumed by infants. This study characterized the TAG profile of human colostrum, transitional, and mature milk samples from 103 women. Significant differences in
Robin M Hobbs et al.
EMBO reports, 16(4), 467-480 (2015-02-24)
Adult tissue maintenance is often dependent on resident stem cells; however, the phenotypic and functional heterogeneity existing within this self-renewing population is poorly understood. Here, we define distinct subsets of undifferentiated spermatogonia (spermatogonial progenitor cells; SPCs) by differential response to
Te-Sheng Chang et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(1), 201-210 (2015-01-08)
To unravel the role of interleukin (IL)-6 and insulin-like growth factor (IGF)-I receptor (IGFIR) in expressing stemness-related properties and to evaluate the prognostic values of pluripotent transcription factor OCT4/NANOG, and IGFIR in hepatocellular carcinoma (HCC). Serum levels of IL6 were
Eric T Alexander et al.
Oncotarget, 7(51), 85291-85305 (2016-11-17)
Cancer is often associated with an increased risk of thrombotic complications which can be aggravated by treatment with chemotherapeutics such as cisplatin. Multiple lines of evidence suggest that thrombin activity promotes tumor growth and metastasis. We examined the effect of
Thao Nguyen et al.
Molecules (Basel, Switzerland), 20(12), 21421-21432 (2015-12-04)
The triacylglycerol (TAG) structure and the regio-stereospecific distribution of fatty acids (FA) of seed oils from most of the Apiaceae family are not well documented. The TAG structure ultimately determines the final physical properties of the oils and the position
Amanda Sampaio Storch et al.
Thrombosis research, 170, 119-125 (2018-09-03)
In vitro and animal model studies have demonstrated that oscillatory shear can trigger vascular hemostasis and remodeling. However, the roles of hemodynamic forces in vascular human biology are not well understood. This study aimed to determine the effects of increasing
Hyo-Jin Jeon et al.
International journal of molecular medicine, 40(6), 1860-1868 (2017-10-19)
Human bone marrow‑derived mesenchymal stem cells (hMSCs) are a desirable cell source for cell‑based therapy to treat nervous system injuries due to their ability to differentiate into specific cell types. In addition to their multipotency, hMSCs render the tissue microenvironment
Zhengxie Zhang et al.
Sensors (Basel, Switzerland), 19(13) (2019-07-07)
The distribution of total electron content (TEC) in the ionosphere is irregular and complex, and it is hard to model accurately. The polynomial (POLY) model is used extensively for regional ionosphere modeling in two-dimensional space. However, in the active period
Yongqi Sun et al.
Bioresource technology, 223, 1-9 (2016-10-25)
Disposal of biomass in the agriculture and steel slags in the steel industry provides a significant solution toward sustainability in China. Herein these two sectors were creatively combined as a novel method, i.e., biomass/CO
Nadia Benabbou et al.
International journal of oncology, 45(4), 1372-1380 (2014-08-07)
The importance of the insulin-like growth factor, IGF, as a signaling axis in cancer development, progression and metastasis is highlighted by its effects on cancer cells, notably proliferation and acquired resistance. The role of the microenvironment within which cancer cells
Ahmed Waraky et al.
Oncotarget, 5(18), 8379-8392 (2014-10-01)
Picropodophyllin (PPP) is an anticancer drug undergoing clinical development in NSCLC. PPP has been shown to suppress IGF-1R signaling and to induce a G2/M cell cycle phase arrest but the exact mechanisms remain to be elucidated. The present study identified
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