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T9576

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Srilakshmi Yalavarthi et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(11), 2990-3003 (2015-06-23)
Antiphospholipid antibodies (aPL), especially those targeting β2 -glycoprotein I (β2 GPI), are well known to activate endothelial cells, monocytes, and platelets, with prothrombotic implications. In contrast, the interaction of aPL with neutrophils has not been extensively studied. Neutrophil extracellular traps...
Habtewold D Waktola et al.
Journal of chromatography. A, 1549, 77-84 (2018-03-29)
Heart-cut multidimensional gas chromatographic (H/C MDGC) methods under suitable flow and high temperature (T) program conditions were developed to separate olive oil triacylglycerols (TAGs). Different column sets were selected for further evaluation, each with relatively short non-polar first dimension (1D)...
Justyna Gogola et al.
Chemosphere, 217, 100-110 (2018-11-11)
Epidemiological studies have found that women have detectable levels of organic pollutants such as hexachlorobenzene (HCB), 2,2-dichlorodiphenyldichloroethylene (p,p'-DDE), polychlorinated biphenyl 153 (PCB153), perfluorooctanoate (PFOA), and perfluorooctane sulfonate (PFOS) in their follicular fluid. Thus, these compounds may directly affect the function...
E Merit Reyes-Reyes et al.
Molecular oncology, 9(7), 1392-1405 (2015-04-26)
AS1411 is a G-rich quadruplex-forming oligodeoxynucleotide that binds specifically to nucleolin, a protein found on the surface and in the cytoplasm of most malignant cells but absent from the surface/cytoplasm of most normal cells. AS1411 has shown promising clinical activity...
Julien Perrin et al.
Shock (Augusta, Ga.), 43(1), 74-79 (2014-09-26)
Sepsis induces alterations of coagulation suggesting both hypercoagulable or hypocoagulable features. The result of their combination remains unknown, making it difficult to predict whether one prevails over the other. Thrombin generation tests (TGTs) stand as an interesting tool to establish...
Jiying Wen et al.
Biomaterials, 86, 42-55 (2016-02-18)
A library of hyperbranched polyglycerols (HPGs) functionalized with different mole fractions of zwitterionic sulfabetaine and cationic quaternary ammonium ligands was synthesized and characterized. A post-polymerization method was employed that utilized double bond moieties on the dendritic HPG for the coupling...
Kazuki Fukushima et al.
Biomacromolecules, 18(11), 3834-3843 (2017-10-04)
We developed a biodegradable polycarbonate that demonstrates antithrombogenicity and vascular cell adhesion via organocatalytic ring-opening polymerization of a trimethylene carbonate (TMC) analogue bearing a methoxy group. The monoether-tagged polycarbonate demonstrates a platelet adhesion property that is 93 and 89% lower...
Anna De Vincenzo et al.
International journal of cancer, 145(10), 2827-2839 (2019-08-06)
Fibroblasts are among the most abundant stromal cells in the tumor microenvironment (TME), progressively differentiating into activated, motile, myofibroblast-like, protumorigenic cells referred to as Cancer-Associated Fibroblasts (CAFs). To investigate the mechanisms by which epithelial cells direct this transition, the early...
Lorella Maniscalco et al.
Veterinary journal (London, England : 1997), 205(2), 272-280 (2014-09-27)
Insulin-like growth factor 1 receptor (IGF-1R) is a cell membrane receptor widely expressed in tissues and involved in different cancers in humans. IGF-1R expression in human osteosarcoma has been associated with the development of tumour metastasis and with prognosis, and...
Zheyu Song et al.
Biomaterials science, 7(4), 1632-1642 (2019-02-06)
In the present research, a tumor-targeted gene carrier, PPP, was constructed through the modification of phenylboronic acid onto the surface of a polyamidoamine dendrimer, and then miR-34a delivery was employed as a model to evaluate its anti-tumor efficacy. The carrier...
Gillian N Pike et al.
Blood, 126(3), 397-405 (2015-04-26)
Individuals with Factor XI (FXI) deficiency have a variable bleeding tendency that does not correlate with FXI:C levels or genotype. Comparing a range of sample conditions, we tested whether the thrombin generation assay (TGA) could discriminate between control subjects (n...
Joaquim V Marques et al.
The Journal of biological chemistry, 288(1), 466-479 (2012-11-20)
Podophyllum species are sources of (-)-podophyllotoxin, an aryltetralin lignan used for semi-synthesis of various powerful and extensively employed cancer-treating drugs. Its biosynthetic pathway, however, remains largely unknown, with the last unequivocally demonstrated intermediate being (-)-matairesinol. Herein, massively parallel sequencing of...
Lin Yang et al.
Redox biology, 17, 180-191 (2018-04-28)
Breast cancer is one of the most lethal tumors in the world, among which 15% are triple-negative breast cancers (TNBCs) with higher metastasis and lower survival rate. Anoikis resistance is a key process during tumor metastasis, which is usually accompanied...
Hui Liu et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 26(4), 408-413 (2015-03-15)
Hereditary coagulation factor VII deficiency (FVIID) is a rare autosomal, recessive inherited hemorrhagic disorder related to a variety of mutations or polymorphisms throughout the factor VII (FVII) gene (F7). The aims of this study were to characterize the molecular defect...
Mikael Lindström et al.
Clinica chimica acta; international journal of clinical chemistry, 482, 78-83 (2018-03-30)
Serotonin (5-hydroxytyramine) is a mediator of gastrointestinal smooth muscle contraction, and is secreted by neuroendocrine neoplasms (NENs). We developed a liquid chromatography tandem mass spectrometry (LC-MS/MS) assay for serum serotonin to be used in NEN diagnostics and follow-up. We used...
Haizhen Wang et al.
Nature, 546(7658), 426-430 (2017-06-14)
D-type cyclins (D1, D2 and D3) and their associated cyclin-dependent kinases (CDK4 and CDK6) are components of the core cell cycle machinery that drives cell proliferation. Inhibitors of CDK4 and CDK6 are currently being tested in clinical trials for patients...
Jo B Andreasen et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 27(1), 24-30 (2015-08-11)
Impaired haemostasis has been reported in children with congenital heart disease undergoing cardiopulmonary bypass. As thrombin generation encompasses all phases of the coagulation process, this analysis might provide the best assessment of global haemostasis. A prospective study was undertaken to...
Rachel Forster et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(10), 11210-11222 (2019-07-12)
Endometriosis is a common incurable inflammatory disorder that is associated with debilitating pelvic pain in women. Macrophages are central to the pathophysiology of endometriosis: they dictate the growth and vascularization of endometriosis lesions and more recently have been shown to...
Shingo Ito et al.
Neurochemistry international, 101, 22-29 (2016-11-05)
We have previously shown in SH-SY5Y human neuroblastoma cells that the expressions of basal (75 kDa) and high molecular weight (HMW; 85 kDa) isoforms of the p75 neurotrophic receptor (p75NTR) are stimulated by amyloid-β peptide1-42 oligomers (AβOs) via the insulin-like growth factor-1...
A Retamales et al.
Biochemical and biophysical research communications, 464(2), 596-602 (2015-07-08)
Myogenic differentiation is a complex and well-coordinated process for generating mature skeletal muscle fibers. This event is autocrine/paracrine regulated by growth factors, principally Myostatin (MSTN) and Insulin-like Growth Factor-1 (IGF-1). Myostatin, a member of the transforming growth factor-β superfamily, is...
Olga Burmistrova et al.
Scientific reports, 9(1), 11670-11670 (2019-08-14)
The glycolytic rate in neurons is low in order to allow glucose to be metabolized through the pentose-phosphate pathway (PPP), which regenerates NADPH to preserve the glutathione redox status and survival. This is controlled by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3), the pro-glycolytic enzyme...
Lin Dong et al.
Acta biochimica et biophysica Sinica, 51(7), 753-760 (2019-06-07)
The type-I insulin-like growth factor receptor (IGF-IR) is overexpressed in endometrial cancer. High IGF-IR expression was considered as an important prognostic factor for tumor progression. The purpose of this study was to investigate the role and molecular mechanism of IGF-IR...
Florian Gaertner et al.
Cell, 171(6), 1368-1382 (2017-12-02)
Blood platelets are critical for hemostasis and thrombosis and play diverse roles during immune responses. Despite these versatile tasks in mammalian biology, their skills on a cellular level are deemed limited, mainly consisting in rolling, adhesion, and aggregate formation. Here...
Brigette Church et al.
PloS one, 14(1), e0210902-e0210902 (2019-01-19)
Extracellular bacteria that spread via the vasculature employ invasive mechanisms that mirror those of metastatic tumor cells, including intravasation into the bloodstream and survival during hematogenous dissemination, arrestation despite blood flow, and extravasation into distant tissue sites. Several invasive bacteria...
Ran Rostoker et al.
Endocrinology, 154(5), 1701-1710 (2013-03-22)
Epidemiological and experimental studies have identified hyperinsulinemia as an important risk factor for breast cancer induction and for the poor prognosis in breast cancer patients with obesity and type 2 diabetes. Recently it was demonstrated that both the insulin receptor...
Zhaoyu Qin et al.
Journal of experimental & clinical cancer research : CR, 38(1), 154-154 (2019-04-12)
Metabolic reprogramming is one of the hallmarks of cancer cells. The pentose phosphate pathway (PPP), a branch of glycolysis, is an important metabolic pathway for the survival and biosynthesis of cancer cells. Transketolase (TKT) is a key enzyme in the...
Vera Chesnokova et al.
Endocrinology, 160(6), 1439-1447 (2019-04-20)
DNA damage occurs as a result of environmental insults and aging and, if unrepaired, may lead to chromosomal instability and tumorigenesis. Because GH suppresses ataxia-telangiectasia mutated kinase phosphorylation, decreases DNA repair, and increases DNA damage accumulation, we elucidated whether GH...
Ayan K Ghosh et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(5), 2081-2098 (2015-02-19)
Understanding the mechanism that allows the intracellular protozoan parasite Leishmania donovani (Ld) to respond to reactive oxygen species (ROS) is of increasing therapeutic importance because of the continuing resistance toward antileishmanial drugs and for determining the illusive survival strategy of...
Rigo Cintron-Colon et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(36), 9731-9736 (2017-08-23)
When food resources are scarce, endothermic animals can lower core body temperature (T
Maria Cristina Righetti et al.
International journal of molecular sciences, 20(3) (2019-02-16)
The thermal, mechanical, and rheological properties of biocomposites of poly(lactic acid) (PLA) with potato pulp powder were investigated in order to (1) quantify how the addition of this filler modifies the structure of the polymeric material and (2) to obtain...
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