Showing 1-30 of 335 results for "

T9284

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Karthik S Prabhakara et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 26(9), 2152-2162 (2018-07-25)
Despite intensive research and clinical trials with numerous therapeutic treatments, traumatic brain injury (TBI) is a serious public health problem in the United States. There is no effective FDA-approved treatment to reduce morbidity and mortality associated with TBI. Inflammation plays...
The role of ZKSCAN3 in the transcriptional regulation of autophagy.
Haihui Pan et al.
Autophagy, 13(7), 1235-1238 (2017-06-06)
Xiangxiang Wei et al.
Science advances, 5(3), eaau7887-eaau7887 (2019-03-21)
The transcription factor BTB and CNC homology 1 (Bach1) is expressed in the embryos of mice, but whether Bach1 regulates the self-renewal and early differentiation of human embryonic stem cells (hESCs) is unknown. We report that the deubiquitinase ubiquitin-specific processing...
Karen M Lammers et al.
Gastroenterology, 135(1), 194-204 (2008-05-20)
Celiac disease is an immune-mediated enteropathy triggered by gliadin, a component of the grain protein gluten. Gliadin induces an MyD88-dependent zonulin release that leads to increased intestinal permeability, a postulated early element in the pathogenesis of celiac disease. We aimed...
Rasa Tamosiuniene et al.
Circulation research, 122(12), 1689-1702 (2018-03-17)
Pulmonary arterial hypertension (PH) is a life-threatening condition associated with immune dysregulation and abnormal regulatory T cell (Treg) activity, but it is currently unknown whether and how abnormal Treg function differentially affects males and females. To evaluate whether and how...
Lígia Sousa-Ferreira et al.
PloS one, 6(5), e19745-e19745 (2011-05-19)
Some pathological conditions with feeding pattern alterations, including obesity and Huntington disease (HD) are associated with hypothalamic dysfunction and neuronal cell death. Additionally, the hypothalamus is a neurogenic region with the constitutive capacity to generate new cells of neuronal lineage...
Paola Matarrese et al.
The Biochemical journal, 413(3), 467-478 (2008-04-30)
Participation of diverse organelles in the intracellular signalling that follows CD95/Fas receptor ligation encompasses a series of subcellular changes that are mandatory for, or even bolster, the apoptotic cascade. In the present study, we analysed the role of endocytosis in...
Agnes Schröder et al.
JCI insight, 4(23) (2019-12-06)
Dietary salt consumption leads to cutaneous Na+ storage and is associated with various disorders, including osteopenia. Here, we explore the impact of Na+ and the osmoprotective transcription factor nuclear factor of activated T cell 5 (NFAT5) on bone density and...
Hugo Boruchowicz et al.
Journal of virology, 94(21) (2020-08-21)
The glycoprotein M of herpes simplex virus 1 (HSV-1) is dynamically relocated from nuclear membranes to the trans-Golgi network (TGN) during infection, but molecular partners that promote this relocalization are unknown. Furthermore, while the presence of the virus is essential...
Dilip Shrestha et al.
Biochimica et biophysica acta, 1840(1), 667-680 (2014-02-01)
Cluster of differentiation 1 (CD1) represents a family of proteins which is involved in lipid-based antigen presentation. Primarily, antigen presenting cells, like B cells, express CD1 proteins. Here, we examined the cell-surface distribution of CD1d, a subtype of CD1 receptors...
Koji Abe et al.
The Journal of pharmacology and experimental therapeutics, 326(3), 983-990 (2008-06-25)
Previous reports have indicated that in vitro biliary clearance (Cl(biliary)) determined in sandwich-cultured hepatocytes correlates well with in vivo Cl(biliary) for limited sets of compounds. This study was designed to estimate the in vitro Cl(biliary) in sandwich-cultured rat hepatocytes (SCRHs)...
Monique Bax et al.
Stem cell research, 40, 101530-101530 (2019-08-25)
Dermal fibroblasts from a 59 year old male patient with amyotrophic lateral sclerosis (symptomatic at the time of collection), attributed to a mutation in the cyclin F gene (CCNFS621G), were reprogrammed using mRNA and microRNA-delivered OSKM factors to induced pluripotent stem...
Sivaram Harendra et al.
Journal of environmental sciences (China), 25(3), 576-584 (2013-08-08)
Surfactants are soil washing agents and facilitators for subsurface remediation of hydrocarbon spills. It is important to understand the sorption and transport behavior of surfactants for enhanced soil remediation. The adsorption and desorption isotherms of cetyl trimethylammonium bromide (CTAB) and...
David J Orchard-Webb et al.
BMC cancer, 14, 754-754 (2014-10-11)
Deregulated expression of the transmembrane glycoprotein CDCP1 (CUB domain-containing protein-1) has been detected in several cancers including colon, lung, gastric, breast, and pancreatic carcinomas. CDCP1 has been proposed to either positively or negatively regulate tumour metastasis. In this study we...
Agata Kranjc et al.
PloS one, 4(3), e4672-e4672 (2009-03-06)
Bestrophins are a recently discovered family of Cl(-) channels, for which no structural information is available. Some family members are activated by increased intracellular Ca2+ concentration. Bestrophins feature a well conserved Asp-rich tract in their COOH terminus (Asp-rich domain), which...
Marni E Harris-White et al.
Neurobiology of disease, 84, 60-68 (2015-03-18)
Autophagy is a fundamental cellular recycling process vulnerable to compromise in neurodegeneration. We now report that a cell-penetrating neurotrophic and neuroprotective derivative of the central nervous system (CNS) metabolite, lanthionine ketimine (LK), stimulates autophagy in RG2 glioma and SH-SY5Y neuroblastoma...
Jieyun Hong et al.
Archives of biochemistry and biophysics, 681, 108260-108260 (2020-01-12)
Preadipocyte differentiation and lipid synthesis are critical steps for intramuscular fat (IMF) deposition and lipid metabolism homeostasis. IMF content of beef not only determines the ratio of muscle to adipose, but also determines the beef quality, flavor, and sensory characteristics....
Rustam R Mundegar et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 56(11), 969-975 (2008-07-23)
Antigen detection with indirect immunohistochemical methods is hampered by high background staining if the primary antibody is from the same species as the examined tissue. This high background can be eliminated in unfixed cryostat sections of mouse skeletal muscle by...
Jason Palladino et al.
Developmental cell, 52(3), 379-394 (2020-02-13)
Centromeres are essential for accurate chromosome segregation and are marked by centromere protein A (CENP-A) nucleosomes. Mis-targeted CENP-A chromatin has been shown to seed centromeres at non-centromeric DNA. However, the requirements for such de novo centromere formation and transmission in vivo...
Sibylle Béchet et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(15), 3104-3118 (2020-03-05)
Krabbe's disease is an infantile neurodegenerative disease, which is affected by mutations in the lysosomal enzyme galactocerebrosidase, leading to the accumulation of its metabolite psychosine. We have shown previously that the S1P receptor agonist fingolimod (FTY720) attenuates psychosine-induced glial cell...
Yexian Yuan et al.
The EMBO journal, 39(7), e103304-e103304 (2020-02-28)
Beneficial effects of resistance exercise on metabolic health and particularly muscle hypertrophy and fat loss are well established, but the underlying chemical and physiological mechanisms are not fully understood. Here, we identified a myometabolite-mediated metabolic pathway that is essential for...
Ewa K Zuba-Surma et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 73A(12), 1116-1127 (2008-10-28)
Recently, we purified a population of CXCR4+/Oct-4+/SSEA-1+/Sca-1+/Lin(-)/CD45(-) very small embryonic-like stem cells (VSELs) from adult murine bone marrow (BM). After using flow cytometry, ImageStream analysis, confocal microscopy, and real time RT-PCR, we report that similar cells could be also identified...
Cedric Auffray et al.
The Journal of experimental medicine, 206(3), 595-606 (2009-03-11)
CX(3)CR1 expression is associated with the commitment of CSF-1R(+) myeloid precursors to the macrophage/dendritic cell (DC) lineage. However, the relationship of the CSF-1R(+) CX(3)CR1(+) macrophage/DC precursor (MDP) with other DC precursors and the role of CX(3)CR1 in macrophage and DC...
Eung-Soo Hwang et al.
Journal of virology, 83(23), 12388-12398 (2009-09-25)
Infection of host cells with human cytomegalovirus (HCMV) induces cell cycle dysregulation. Two HCMV immediate-early (IE) proteins, IE1-72 and IE2-86, are promiscuous transactivators that have been implicated in the dysregulatory events. Cellular p53 protein is accumulated to high levels in...
Henning Onsbring et al.
Current biology : CB, 28(8), 1281-1288 (2018-04-10)
While ciliates of the genus Stentor are known for their ability to regenerate when their cells are damaged or even fragmented, the physical and molecular mechanisms underlying this process are poorly understood. To identify genes involved in the regenerative capability...
Marita Pall et al.
Fertility and sterility, 91(6), 2551-2556 (2008-06-17)
To test the hypothesis that DHEAS production from DHEA occurs in hepatic cells and that this production is augmented by the presence of sex steroids or insulin. In vitro prospective experiment. Academic medical center. Hepatoma G2 cells cultured in media...
Rodrigo Maldonado et al.
Molecular cell, 73(6), 1243-1254 (2019-02-17)
Chromatin-associated non-coding RNAs modulate the epigenetic landscape and its associated gene expression program. The formation of triple helices is one mechanism of sequence-specific targeting of RNA to chromatin. With this study, we show an important role of the nucleosome and...
Zbigniew Darzynkiewicz et al.
Methods (San Diego, Calif.), 44(3), 250-254 (2008-03-04)
Activation of endonucleases that cleave chromosomal DNA preferentially at internucleosomal sections is a hallmark of apoptosis. DNA fragmentation revealed by the presence of a multitude of DNA strand breaks, therefore, is considered to be the gold standard for identification apoptotic...
Luis Muniz-Feliciano et al.
Autophagy, 13(12), 2072-2085 (2017-09-22)
Macroautophagy/autophagy is an intracellular stress survival and recycling system whereas phagocytosis internalizes material from the extracellular milieu; yet, both pathways utilize lysosomes for cargo degradation. Whereas autophagy occurs in all cells, phagocytosis is performed by cell types such as macrophages...
Wan-Heng Wang et al.
The Journal of clinical investigation, 118(3), 1056-1064 (2008-02-16)
Elevated intraocular pressure (IOP) is the principal risk factor for glaucoma and results from excessive impedance of the fluid outflow from the eye. This abnormality likely originates from outflow pathway tissues such as the trabecular meshwork (TM), but the associated...