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Thomas Harder et al.
Cell communication and signaling : CCS, 12, 74-74 (2014-12-09)
TGFβ1 (Transforming Growth Factor-beta1) is a versatile regulator of T cell immune responses. Depending on its context in the immunological environment, TGFβ1 guides T cells toward specific activation programs including TH17 and regulatory T cell activities. Moreover, TGFβ signals function
Raquel Cabezón et al.
Journal of leukocyte biology, 97(4), 751-760 (2015-01-28)
The aim of this study was to test the hypothesis whether MERTK, which is up-regulated in human DCs treated with immunosuppressive agents, is directly involved in modulating T cell activation. MERTK is a member of the TAM family and contributes
Yongyin Li et al.
Hepatology (Baltimore, Md.), 58(4), 1277-1286 (2013-05-25)
Given the clinical significance of hepatitis B e antigen (HBeAg) seroconversion in chronic hepatitis B virus (HBV) infection, it is critical to elucidate the mechanisms regulating this process. In the present study, we found that the frequency of circulating chemokine
Joshua M Eichhorn et al.
PloS one, 9(11), e113283-e113283 (2014-11-22)
Microtubule inhibitors are widely used in cancer chemotherapy. These drugs characteristically induce mitotic arrest and cell death but the mechanisms linking the two are not firmly established. One of the problems is that cancer cells vary widely in their sensitivity
Kaveri Sidhu et al.
Biochimica et biophysica acta, 1849(11), 1319-1328 (2015-09-15)
In metazoans, DNA replication is a highly regulated and ordered process that occurs during the S phase of cell cycle. It begins with the licensing of origins of replication usually found in close proximity of actively transcribing genes owing perhaps
Guizhong Zhang et al.
Biochimica et biophysica acta, 1852(8), 1574-1584 (2015-04-29)
Proliferation of vascular smooth muscle cells (VSMCs) plays an important role in restenosis, a disease characterized by smooth muscle cell hyperplasia and neointimal formation. How proliferation signals are controlled to avoid restenosis is not fully understood. Here we report that
Seung Jin Lee et al.
European journal of nuclear medicine and molecular imaging, 41(7), 1327-1335 (2014-02-25)
Thymidine phosphorylase (TP), a key enzyme in the pyrimidine nucleoside salvage pathway, catalyses the reversible phosphorylation of thymidine, thereby generating thymine and 2-deoxy-D-ribose-1-phosphate. By regulating the levels of endogenous thymidine, TP may influence [(18)F]fluorothymidine ([(18)F]FLT) uptake. We investigated the effect
Tohru Takahashi et al.
Stem cells translational medicine, 3(12), 1484-1494 (2014-10-15)
Multipotent mesenchymal stromal cell (MSC) therapy and costimulation blockade are two immunomodulatory strategies being developed concomitantly for the treatment of immunological diseases. Both of these strategies have the capacity to inhibit immune responses and induce regulatory T cells; however, their
Tzi Bun Ng et al.
Applied biochemistry and biotechnology, 177(6), 1374-1385 (2015-08-26)
Lectins have captured the attention of a large number of researchers on account of their various exploitable activities, including antitumor, immunomodulatory, antifungal, as well as HIV reverse transcriptase inhibitory activities. A mannose/glucose-specific lectin was isolated from green split peas (a
Edward J Gane et al.
Gastroenterology, 146(1), 138-146 (2013-09-27)
There is a close relationship between chronic hepatitis B virus infection and chronic renal disease. We analyzed changes in renal function using different markers of glomerular filtration rate (GFR) in multiple studies of telbivudine treatment of patients with chronic hepatitis
Tiago Ferronha et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(7), 2773-2783 (2013-02-15)
Neuroblastoma is an embryonic tumor derived from cells of the neural crest. Taking advantage of a newly developed neural crest lineage tracer and based on the hypothesis that the molecular mechanisms that mediate neural crest delamination are also likely to
Jonathan P Gumucio et al.
Journal of applied physiology (Bethesda, Md. : 1985), 117(11), 1287-1291 (2014-10-04)
Mechanical loading can increase tendon cross-sectional area (CSA), but the mechanisms by which this occurs are largely unknown. To gain a greater understanding of the cellular mechanisms of adult tendon growth in response to mechanical loading, we used a synergist
Joanne C McNelis et al.
American journal of physiology. Endocrinology and metabolism, 305(9), E1134-E1144 (2013-09-12)
Glucocorticoids increase adipocyte proliferation and differentiation, a process underpinned by the local reactivation of inactive cortisone to active cortisol within adipocytes catalyzed by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The adrenal sex steroid precursor dehydroepiandrosterone (DHEA) has been shown to inhibit
Johannes Zander et al.
Infection and immunity, 76(4), 1333-1339 (2007-12-28)
Thymidine-dependent small-colony variants (SCVs) of Staphylococcus aureus are frequently associated with persistent and recurrent infections in cystic fibrosis patients. The phenotypic appearance of S. aureus SCVs or normal-colony variants (NCVs) is postulated to be affected by the intracellular amount of
Daniel M Reed et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(6), 2595-2602 (2015-03-10)
There is an urgent unmet need for human tissue bioassays to predict cytokine storm responses to biologics. Current bioassays that detect cytokine storm responses in vitro rely on endothelial cells, usually from umbilical veins or cell lines, cocultured with freshly
David E A Kloet et al.
The Biochemical journal, 469(2), 289-298 (2015-05-21)
Activity of FOXO (forkhead box O) transcription factors is inhibited by growth factor-PI3K (phosphoinositide 3-kinase)-PKB (protein kinase B)/Akt signalling to control a variety of cellular processes including cell cycle progression. Through comparative analysis of a number of microarray datasets we
Mauro De Santi et al.
Anti-cancer agents in medicinal chemistry, 15(7), 896-904 (2015-01-24)
Natural products such as aromatase inhibitors have been the object of growing attention in recent years because of their potential to inhibit aromatase with fewer side effects and the possible translation of their current use as chemotherapeutic agents to future
Delphine Trochet et al.
Biochimie, 113, 100-110 (2015-04-18)
Telomere erosion leading to replicative senescence has been well documented in human and anthropoid primates, and provides a clue against tumorigenesis. In contrast, other mammals, such as laboratory mice, with short lifespan and low body weight mass have different telomere
Jason Alexander Ji-Xhin Wong et al.
Journal of virology, 88(24), 14278-14288 (2014-10-03)
Although effective hepatitis C virus (HCV) antivirals are on the horizon, a global prophylactic vaccine for HCV remains elusive. The diversity of the virus is a major concern for vaccine development; there are 7 major genotypes of HCV found globally.
Le-Yue Du et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1006, 130-137 (2015-11-10)
Nucleotides, nucleosides and nucleobases have been proven as important bioactive compounds related to many physiological processes. Abelmoschus manihot (L.) Medicus from the family of Malvaceae is an annual herbal plant of folk medicine widely distributed in Oceania and Asia. However
Helen Chen et al.
Cell cycle (Georgetown, Tex.), 13(14), 2248-2261 (2014-05-31)
Construction of a mitotic spindle requires biochemical pathways to assemble spindle microtubules and structural proteins to organize these microtubules into a bipolar array. Through a complex with dynein, the receptor for hyaluronan-mediated motility (RHAMM) cross-links mitotic microtubules to provide structural
Aiman A Haqqani et al.
Virology journal, 12, 184-184 (2015-11-13)
Template switching between two distinct HIV-1 RNA genomes during reverse transcription gives rise to recombinant viruses that greatly expand the genetic diversity of HIV-1 and have adverse implications for drug resistance, immune escape, and vaccine design. Virions with two distinct
Simone Fuchs et al.
Journal of cellular and molecular medicine, 19(5), 1021-1032 (2015-03-11)
Haemanthus coccineus extracts (HCE) have traditionally been used to treat a variety of diseases, like febrile colds or asthma. Since new therapeutic options against inflammatory processes are still urgently needed, we aimed to pharmacologically characterise the anti-inflammatory potential of HCEin
Yan-Zhong Guan et al.
Molecular neurobiology, 51(3), 1480-1488 (2014-08-07)
Ischemic injury in rodent models reliably leads to the activation of microglia, which might play a detrimental role in neuronal survival. Our preliminary studies suggest that nicotine plays a potential role in decreasing the numbers of cultured microglia in vitro.
Kif20a inhibition reduces migration and invasion of pancreatic cancer cells
Stangel D, et al.
The Journal of Surgical Research, 197(1), 91-100 (2015)
Szu-Wei Chang et al.
PloS one, 9(10), e110882-e110882 (2014-10-24)
The papillomavirus E2 protein is involved in the maintenance of persistent infection and known to bind either to cellular factors or directly to mitotic chromosomes in order to partition the viral genome into the daughter cells. However, how the HPV-16
Chandirasegaran Massilamany et al.
PloS one, 9(5), e98506-e98506 (2014-06-01)
We recently reported that Acanthamoeba castellanii (ACA), an opportunistic pathogen of the central nervous system (CNS) possesses mimicry epitopes for proteolipid protein (PLP) 139-151 and myelin basic protein 89-101, and that the epitopes induce experimental autoimmune encephalomyelitis (EAE) in SJL
Jongshin Kim et al.
Nature communications, 6, 6781-6781 (2015-04-08)
Primary cilia exert a profound impact on cell signalling and cell cycle progression. Recently, actin cytoskeleton destabilization has been recognized as a dominant inducer of ciliogenesis, but the exact mechanisms regulating ciliogenesis remain poorly understood. Here we show that the
Fan Jia et al.
Cell reports, 30(6), 1848-1861 (2020-02-13)
Nucleotide deprivation and imbalance present detrimental conditions for animals and are thus expected to trigger cellular responses that direct protective changes in metabolic, developmental, and behavioral programs, albeit such mechanisms are vastly underexplored. Following our previous finding that Caenorhabditis elegans
Jia Li et al.
International journal of oncology, 45(4), 1547-1555 (2014-07-30)
Cell division cycle 20 (CDC20) encodes a regulatory protein interacting with the anaphase-promoting complex/cyclosome (APC/C) in the cell cycle and plays important roles in tumorigenesis and progression of multiple tumors. The present study aimed to investigate the clinical significance of
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