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Xiaohu Xia et al.
ACS nano, 9(10), 9994-10004 (2015-09-04)
Peroxidase mimics with dimensions on the nanoscale have received great interest as emerging artificial enzymes for biomedicine and environmental protection. While a variety of peroxidase mimics have been actively developed recently, limited progress has been made toward improving their catalytic
Raimo A Ketola et al.
Forensic science international, 249, e7-11 (2015-02-17)
Kavalactones are a group of compounds found in kava, a beverage or extract prepared from the rhizome of the kava plant (Piper methysticum). Traditionally kava extracts have been used for their anxiolytic and sedative properties. Sales of kava extracts were
Varun Kesherwani et al.
Neuroscience letters, 576, 45-50 (2014-06-07)
Fasudil (HA-1077), a specific Rho kinase II (ROCKII) inhibitor, is in clinical trials for recovery from spinal cord injury (SCI). The primary role of Fasudil is in axonal regeneration, as it inhibits ROCKII, the key signaling molecule involved in collapse
Extraction of membrane proteins by differential solubilization for separation using two-dimensional gel electrophoresis.
Molloy MP, et al.
Electrophoresis, 19(5), 837-844 (1998)
Bahram Mirani et al.
European journal of pharmacology, 854, 201-212 (2019-04-12)
Treatment of glioblastoma (GBM), as the most lethal type of brain tumor, still remains a major challenge despite the various therapeutic approaches developed over the recent decades. GBM is considered as one of the most therapy-resistant human tumors. Treatment with
Ya Jin et al.
Electrophoresis, 36(15), 1711-1723 (2015-05-02)
Soluble proteins of human bronchial smooth muscle cells (HBSMC) were separated by nondenaturing micro 2DE and a 30 mm × 40 mm area of the CBB-stained slab gel (1.0 mm thick) was cut into 1.1 mm × 1.1 mm squares
Michaela Herrmann et al.
European biophysics journal : EBJ, 44(7), 503-512 (2015-05-29)
Bilayer mechanical properties are not only of crucial importance to the mechanism of action of mechanosensation in lipid membranes but also affect preparative laboratory tasks such as membrane-protein refolding. We report this for coupled refolding and bilayer insertion of outer membrane
Sang Hyun Choi et al.
Thyroid : official journal of the American Thyroid Association, 25(8), 897-903 (2015-05-16)
The accurate diagnosis of thyroid nodules is important for making management decisions. The purpose of this study is to evaluate the clinical usefulness of BRAF(V600E) mutation analysis with core-needle biopsy (CNB+BRAF(V600E)) in thyroid nodules with previous atypia of undetermined significance
Ujala Rana et al.
Journal of inorganic biochemistry, 102(3), 489-499 (2008-01-04)
Many cell types contain metal-ion unsaturated metallothionein (MT). Considering the Zn(2+) binding affinity of metallothionein, the existence of this species in the intracellular environment constitutes a substantial "thermodynamic sink". Indeed, the mM concentration of glutathione may be thought of in
Lisa Mathiasen et al.
PloS one, 10(4), e0125789-e0125789 (2015-04-10)
Human PREP1 and PBX1 are homeodomain transcriptional factors, whose biochemical and structural characterization has not yet been fully described. Expression of full-length recombinant PREP1 (47.6 kDa) and PBX1 (46.6 kDa) in E. coli is difficult because of poor yield, high
E O Farombi et al.
Andrologia, 46(8), 893-901 (2013-10-02)
The indiscriminate use, abuse and patients' noncompliance to normal prescription of artemisinin and its derivatives are a common practice during the treatment for drug-resistant malaria parasites in most developing countries. This study investigated the influence of artemisinin on the testicular
Wei Li et al.
Biosensors & bioelectronics, 70, 304-309 (2015-04-04)
DNA methylation catalyzed by methyltransferase (MTase) plays an important role in many biological processes, including gene transcription, genomic imprinting and cellular differentiation. Herein, a simple and novel homogeneous electrochemical strategy for ultrasensitive DNA MTase activity assay has been successfully developed
Szymon Dziomba et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1001, 17-21 (2015-08-09)
An electrophoretic method for fast separation of three tropane alkaloids (hyoscyamine, anisodamine and scopolamine) was presented. The substances were complete resolved in less than one minute due to utilization of relatively short capillary (20.2cm effective length) and high voltage (25kV).
Afshin Amini et al.
Journal of experimental & clinical cancer research : CR, 33, 92-92 (2014-11-27)
Bromelain and N-acetylcysteine are two natural, sulfhydryl-containing compounds with good safety profiles which have been investigated for their benefits and application in health and disease for more than fifty years. As such, the potential values of these agents in cancer
Julieta Correa-Betanzo et al.
Journal of agricultural and food chemistry, 63(11), 2935-2946 (2015-03-03)
Biological activity of polyphenols is influenced by their uptake and is highly influenced by their interactions with the food matrix. This study evaluated the complex formation of blueberry polyphenols with fruit matrixes such as pectin and cellulose and their effect
David S Jones et al.
Molecular pharmaceutics, 12(8), 2928-2936 (2015-06-26)
This paper presents a novel strategy for the prevention of ventilator-associated pneumonia that involves coating poly(vinyl chloride, PVC) endotracheal tubes (ET) with hydrogels that may be subsequently used to entrap nebulized antimicrobial solutions. Candidate hydrogels were prepared containing a range
Jeffrey S Derrick et al.
Journal of the American Chemical Society, 137(46), 14785-14797 (2015-11-18)
Chemical reagents targeting and controlling amyloidogenic peptides have received much attention for helping identify their roles in the pathogenesis of protein-misfolding disorders. Herein, we report a novel strategy for redirecting amyloidogenic peptides into nontoxic, off-pathway aggregates, which utilizes redox properties
Andreas Reisch et al.
ACS nano, 9(5), 5104-5116 (2015-04-22)
Ultrasmall polymer nanoparticles are rapidly gaining importance as nanocarriers for drugs and contrast agents. Here, a straightforward modular approach to efficiently loaded and stable sub-20-nm polymer particles is developed. In order to obtain ultrasmall polymer nanoparticles, we investigated the influence
Ting Hou et al.
The Analyst, 140(16), 5748-5753 (2015-07-15)
Herein, a highly sensitive and versatile homogeneous electrochemical biosensing strategy is proposed, based on the split aptamer-incorporated DNA three-way junction and the exonuclease (Exo) III-assisted target recycling. The aptamer of adenosine triphosphate (ATP, chosen as the model analyte) is split
Chulwon Kim et al.
Oncotarget, 6(6), 4020-4035 (2015-03-05)
Artesunate (ART), a semi-synthetic derivative of artemisinin, is one of the most commonly used anti-malarial drugs. Also, ART possesses anticancer potential albeit through incompletely understood molecular mechanism(s). Here, the effect of ART on various protein kinases, associated gene products, cellular
Erica Dorigatti de Avila et al.
Biomaterials, 67, 84-92 (2015-07-27)
Bacterial biofilm infections remain prevalent reasons for implant failure. Dental implant placement occurs in the oral environment, which harbors a plethora of biofilm-forming bacteria. Due to its trans-mucosal placement, part of the implant structure is exposed to oral cavity and
Heidary Shayesteh Tavakol et al.
Toxicology and industrial health, 31(9), 862-867 (2013-04-12)
Chemical materials are environmental contaminants, are extensively used in laboratories, and may cause various forms of health hazards in laboratory workers. Therefore, this toxicity most likely is a result of the oxidative metabolism of chemical to reactive products. As green
M L Lima et al.
Transplantation proceedings, 44(8), 2326-2332 (2012-10-03)
There is a growing need to improve heart preservation benefit the performance of cardiac operations, decrease morbidity, and more important, increase the donor pool. Therefore, the objective of this study was to evaluate the cardioprotective effects of Krebs-Henseleit buffer (KHB)
Marzia Salzillo et al.
Journal of basic microbiology, 55(7), 890-897 (2015-02-28)
Collagen is a target of pathogens for adhesion, colonization, and invasion of host tissue. Probiotic bacteria can mimic the same mechanism as used by the pathogens in the colonization process, expressing cell surface proteins that specifically interact with extracellular matrix
Sui Ching Phung et al.
Analytical and bioanalytical chemistry, 407(23), 6995-7002 (2015-07-06)
Counter-pressure was used to extend the duration of field-amplified sample injection in isotachophoresis (FASI-ITP) in order to improve the detection of bacterial cells. Using 0.51-μm negatively charged encapsulated fluorescent beads as a model, the counter-pressure, injection and separation voltages, and
Duraisamy Ponnusamy et al.
Infection and immunity, 83(5), 2065-2081 (2015-03-11)
The identification of new virulence factors in Yersinia pestis and understanding their molecular mechanisms during an infection process are necessary in designing a better vaccine or to formulate an appropriate therapeutic intervention. By using a high-throughput, signature-tagged mutagenic approach, we
Blanca V Rodriguez et al.
Analytical biochemistry, 492, 69-75 (2015-09-30)
High-quality chromosomal DNA is a requirement for many biochemical and molecular biological techniques. To isolate cellular DNA, standard protocols typically lyse cells and separate nucleic acids from other biological molecules using a combination of chemical and physical methods. After a
Qi Yin et al.
Journal of biomedical nanotechnology, 11(10), 1764-1775 (2015-10-28)
The clinical success of anthracyclines-containing chemotherapy for breast cancer is mainly restricted by cardiac damage and the development of multidrug resistance (MDR). For efficient reversal of drug resistance, doxorubicin (DOX) loaded multifunctional bioreducible micelles were constructed from a new amphiphilic
Roger A Vaughan et al.
Journal of physiology and biochemistry, 71(4), 679-689 (2015-09-25)
Exercise offers several benefits for health, including increased lean body mass and heightened energy expenditure, which may be partially attributable to secretory factors known as myokines. Irisin, a recently identified myokine, was shown to increase metabolic rate and mitochondrial content
Adriana Lizbeth Juárez-Rojas et al.
Systems biology in reproductive medicine, 61(4), 211-221 (2015-04-14)
Testicular apoptosis is activated by stress, but it is not clear which signaling pathway is activated in response to stress. The aim of this study was to investigate whether intrinsic, extrinsic, or both apoptotic signaling pathways are activated by acute
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