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Ilya B Zavodnik et al.
Life sciences, 92(23), 1110-1117 (2013-05-07)
The present study was designed for further evaluation of the biochemical mechanism of hepatic mitochondrial dysfunction under oxidative damages induced by organic hydroperoxide, tert-butyl hydroperoxide (tBHP), for estimation of the molecular targets impaired during oxidative stress, and for investigation of
Thiyagarajan Ramesh et al.
Metabolic brain disease, 30(2), 573-582 (2014-09-14)
Cigarette smoking is concerned as a major risk factor in the development of various neurological disorders. Oxidative stress is suggested as a possible contributing factor in the pathogenesis of cigarette smoking-induced toxicity. Therefore, the present study was intended to evaluate
ZhengLin Zhao et al.
Chemico-biological interactions, 225, 13-20 (2014-12-03)
Glycyrrhizae radix (G. radix) has been demonstrated to have hepatoprotective properties. This study determined the therapeutic effects of isoliquiritigenin (isoLQ) in G. radix, against liver injury induced by CCl4 in rats. CCl4 (0.5 ml/kg/d, twice) or CCl4 plus buthionine sulfoximine
Song-Xue Guo et al.
Journal of translational medicine, 13, 183-183 (2015-06-07)
Early acute kidney injury (AKI) in severely burned patients predicts a high mortality that is multi-factorial. Hydrogen has been reported to alleviate organ injury via selective quenching of reactive oxygen species. This study investigated the potential protective effects of hydrogen
Ping Zhao et al.
Oxidative medicine and cellular longevity, 2015, 645814-645814 (2015-09-09)
Pulmonary fibrosis (PF) is a serious chronic lung disease with unknown pathogenesis. Researches have confirmed that oxidative stress which is regulated by NADPH oxidase-4 (NOX4), a main source of reactive oxygen species (ROS), is an important molecular mechanism underlying PF.
Jingjing Xie et al.
Poultry science, 94(7), 1635-1644 (2015-04-26)
Heat tolerance can be improved by feed restriction in broiler chickens. It is unknown whether the same is true for broiler breeders, which are restrictedly fed. Therefore, the current study was conducted to study the effects of heat stress on
Camila Eliza Fernandes Pazzini et al.
International journal of medical sciences, 12(6), 478-486 (2015-06-17)
The literature indicates that red wine presents in its composition several substances that are beneficial to health. This study has investigated the antioxidant effects of Tannat red wine on oxidative stress induced by glucose and fructose in erythrocytes in vitro
Reham M El-Meligy et al.
Journal of enzyme inhibition and medicinal chemistry, 30(2), 250-258 (2014-05-09)
The aim of the present study was to evaluate both prophylactic and curative anti-ulcerative colitis activity and the possible mechanism of action of seven desert plant extracts. Seven desert plants from different families; Conyza dioscoridis (L.) Desf. (Asteraceae), Euphorbia hirta
Xiaomei Lu et al.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 35(3), 306-311 (2015-08-05)
To evaluate the protection of danshen (Radix Salviae Miltiorrhizae) (SM) injection in myocardial infarction (MI) induced renal damage. Forty male C57 mice were divided into control group, MI group and SM group. In MI group, the left coronary artery was
Noha M Saeed et al.
Biochemical pharmacology, 95(3), 145-155 (2015-02-24)
Doxorubicin (DOX) is a widely used chemotherapeutic agent however its clinical use is limited by cumulative cardiotoxicity. Epigallocatechin-3-gallate (EGCG), a main catechin in green tea, possesses a potent antioxidant, anti-apoptotic and anticancer properties. The current study aimed to investigate the
Soo Jung Choi et al.
Journal of medicinal food, 17(11), 1222-1231 (2014-08-19)
Alzheimer's disease (AD) is pathologically characterized by the presence of amyloid plaques in brain and the overproduction of amyloid beta (Aβ), leading to learning and memory impairment and intense oxidative stress. In this study, the protective effect of Ligularia fischeri
Ibtissem Ben Amara et al.
Environmental science and pollution research international, 22(16), 12309-12322 (2015-07-27)
Maneb (MB), a fungicide largely used in agriculture throughout the world including Tunisia, protects many vegetables, fruits and field crops against a wide spectrum of fungal diseases. However there is a lack of informations regarding the risks arising from MB
Mônica Cruvinel de Lima et al.
Acta cirurgica brasileira, 27(8), 544-551 (2012-08-02)
To evaluate the influence of aerobic exercise on oxidative stress in mice. The study included twenty female mice Mus musculus-Swiss divided into two groups: sedentary control (GA) and exercise (GB), each containing ten animals. All animals underwent an adaptation period
Dayanidhi Kumar et al.
Environmental research, 132, 297-304 (2014-05-20)
There is a paucity of data regarding the association between occupational radiation exposure and risk to human fertility. Recently, we provided the first evidence on altered sperm functional characteristics, DNA damage and hypermethylation in radiation health workers. However, there is
Qin Yan et al.
European journal of medicinal chemistry, 44(10), 4235-4243 (2009-06-26)
A series of novel 5-benzylidene barbiturate and thiobarbiturate derivatives were synthesized and evaluated as tyrosinase inhibitors and antibacterial agents. The results demonstrated that some compounds had more potent inhibitory activities than the parent compound 4-hydroxybenzaldehyde (IC(50)=1.22 mM). Particularly, compounds 1a
Anil Kumar et al.
Inflammopharmacology, 23(6), 291-305 (2015-07-01)
Potential role of angiotensin-II and cyclooxygenase have been suggested in the pathophysiology of chronic fatigue stress. The present study has been designed to evaluate the neuroprotective effect of losartan and its interaction with nimesulide against chronic fatigue stress and related
Asokan Prema et al.
Neuroscience letters, 599, 12-19 (2015-05-20)
Parkinson's disease (PD) is the second most common neurodegenerative disorder that mainly affects the movement of the aged populations. Lycopene is a carotenoid with unique pharmacological properties and its efficacy on experimental Hunginton's disease and brain ischemia has shown intense
Reem N El-Naga et al.
Neurotoxicology, 44, 48-57 (2014-06-01)
The relationship between inflammation, oxidative stress and the incidence of depression had been well studied. Indole-3-carbinol (I3C), a natural active compound found in cruciferous vegetables, was shown to have anti-oxidant and anti-inflammatory activities. Therefore, the aim of this study was
Ling Zhao et al.
Oxidative medicine and cellular longevity, 2015, 309125-309125 (2015-08-11)
Organophosphate pesticides (OPs) are among the most widely used synthetic chemicals for the control of a wide variety of pests, and reactive oxygen species (ROS) caused by OPs may be involved in the toxicity of various pesticides. Previous studies have
Ebtesam M Al-Olayan et al.
International journal of experimental pathology, 96(3), 196-202 (2015-04-22)
Aluminium (Al) toxicity is closely linked to the pathogenesis of Alzheimer's disease (AD). This experimental study investigated the neuroprotective effect of melatonin (Mel; 10 mg/kg bwt) on aluminium chloride (AlCl3 ; 34 mg/kg bwt) induced neurotoxicity and oxidative stress in rats. Adult
Amporn Jariyapongskul et al.
BioMed research international, 2015, 785826-785826 (2015-05-08)
The present study examined effects of alpha-mangostin (α-MG) supplementation on the retinal microvasculature, including ocular blood flow (OBF) and blood-retinal barrier (BRB) permeability in a type 2 diabetic animal model. Male Sprague-Dawley rats were divided into four groups: normal control
Chun-Feng Lu et al.
Ecotoxicology and environmental safety, 122, 537-544 (2015-10-04)
Growing evidence has confirmed that exposure to ambient particulate matters (PM) is associated with increased morbidity and mortality of cardiovascular and pulmonary diseases. Ambient PM is a complex mixture of particles and air pollutants. Harmful effects of PM are specifically
Krassimira Yoncheva et al.
International journal of pharmaceutics, 490(1-2), 298-307 (2015-06-01)
The aim of the present study was to develop curcumin loaded cationic polymeric micelles and to evaluate their loading, preservation of curcumin antioxidant activity and intracellular uptake ability. The micelles were prepared from a triblock copolymer consisting of poly(ϵ-caprolactone) and
Antonios Papastergiadis et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 73, 51-58 (2014-07-19)
Malondialdehyde (MDA), 4-Hydroxy-2-(E)-Nonenal (HNE) and 4-Hydroxy-2-(E)-Hexenal (HHE) are reactive aldehydes found in foods and are formed due to decomposition of polyunsaturated fatty acid hydroperoxides. In the present study, sixteen food categories were analyzed for the aforementioned aldehydes and in combination
Münire Nalan Tüzmen et al.
Toxicology mechanisms and methods, 25(2), 120-127 (2014-12-17)
Exposure to aluminum (Al) and lead (Pb) can cause brain damage. Also, Pb and Al exposure alters N-methyl-d-aspartate receptor (NMDAR) subunit expression. Polyphenols such as tannic acid and curcumin are very efficient chelator for metals. The effects of curcumin and
Afolabi C Akinmoladun et al.
Journal of basic and clinical physiology and pharmacology, 26(6), 555-562 (2015-03-27)
Novel hepatoprotectives are needed to address the increasing cases of liver problems worldwide. Pterocarpus erinaceus Poir (Fabaceae) ethanol stem bark extract (PE) and its constituent flavonoid, homopterocarpin (HP), were investigated for their protective property in acetaminophen-induced oxidative stress and liver
Kristeena Ray et al.
Pain, 156(3), 528-539 (2015-01-20)
Endometriosis is a disease characterized by the growth of endometrial tissue outside the uterus and is associated with chronic pelvic pain. Peritoneal fluid (PF) of women with endometriosis is a dynamic milieu and is rich in inflammatory markers, pain-inducing prostaglandins
Mamdouh S Masoud et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 107, 179-187 (2013-02-19)
Synthesis of 5-arylidine thiobarbituric acids containing different functional groups with variable electronic characters were described and their Co(2+), Ni(2+) and Cu(2+) complexes. The stereochemistry and mode of bonding of 5-(substituted benzylidine)-2-TBA complexes were achieved based on elemental analysis, spectral (UV-VIS
Gopal Krushna Pal et al.
Clinical and experimental hypertension (New York, N.Y. : 1993), 37(8), 609-615 (2015-06-27)
Salt preference has been reported to cause sympathovagal imbalance (SVI) and prehypertension. We investigated the role of inflammation, insulin resistance (IR), hyperlipidemia, and oxidative stress (OS) in genesis of SVI and cardiovascular (CV) risks in salt-preferring prehypertensives. The subjects were
Kozi Hosoya et al.
Kidney international, 87(4), 749-760 (2014-10-23)
In this study, we examined the association between chronic kidney disease (CKD) and insulin resistance. In a patient cohort with nondiabetic stages 2-5 CKD, estimated glomerular filtration rate (eGFR) was negatively correlated and the plasma aldosterone concentration was independently associated
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