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Emily L Clark et al.
PLoS genetics, 13(9), e1006997-e1006997 (2017-09-16)
Sheep are a key source of meat, milk and fibre for the global livestock sector, and an important biomedical model. Global analysis of gene expression across multiple tissues has aided genome annotation and supported functional annotation of mammalian genes. We
Yan Liu et al.
Nature communications, 8(1), 643-643 (2017-09-25)
Studies of heterochronic parabiosis demonstrated that with age, the composition of the circulatory milieu changes in ways that broadly inhibit tissue regenerative capacity. In addition, local tissue niches have age-specific influences on their resident stem cells. Here we use bio-orthogonal
M Jakir S K Pinjari et al.
Indian journal of pharmacology, 49(4), 297-303 (2018-01-13)
The objective of this study is to investigate For the purpose, Caco2 permeability assay, mouse microsomal stability assay and In Caco-2 permeability assay, paromomycin showed negligible permeability in the apical to basolateral (A-to-B) direction and vice versa (B-to-A). Marginal increase
Mark E Corkins et al.
Genes, 9(4) (2018-04-13)
Xenopus laevis embryos are an established model for studying kidney development. The nephron structure and genetic pathways that regulate nephrogenesis are conserved between Xenopus and humans, allowing for the study of human disease-causing genes. Xenopus embryos are also amenable to
Hiroshi Sunami et al.
Advanced biosystems, 4(10), e2000113-e2000113 (2020-09-15)
The present study demonstrates unidirectional cell migration using a novel 3D microfabricated scaffold, as revealed by the uneven sorting of cells into an area of 1 mm × 1 mm. To induce unidirectional cell migration, it is important to determine the optimal
Ling Xue et al.
The Journal of nutritional biochemistry, 19(5), 336-344 (2007-08-21)
3,3'-Diindolylmethane (DIM), a major condensation product of indole-3-carbinol, exhibits chemopreventive properties in animal models of cancer. Recent studies have shown that DIM stimulates interferon-gamma (IFN-gamma) production and potentiates the IFN-gamma signaling pathway in human breast cancer cells via a mechanism
Pawel Mroz et al.
Cancer letters, 282(1), 63-76 (2009-04-07)
The in vitro photodynamic therapy activity of four imidazole-substituted metalloporphyrins has been studied using human (HeLa) and mouse (CT26) cancer cell lines: an anionic Zn porphyrin and a homologous series of three cationic Zn, Pd or InCl porphyrins. A dramatic
Wishrawana S Ratnayake et al.
International journal of oncology, 51(5), 1370-1382 (2017-10-20)
Atypical protein kinase Cs (aPKC) are involved in cell cycle progression, tumorigenesis, cell survival and migration in many cancers. We believe that aPKCs play an important role in cell motility of melanoma by regulating cell signaling pathways and inducing epithelial
Adam D Pfefferle et al.
Disease models & mechanisms, 12(7) (2019-06-20)
The Wnt gene family encodes an evolutionarily conserved group of proteins that regulate cell growth, differentiation and stem cell self-renewal. Aberrant Wnt signaling in human breast tumors has been proposed as a driver of tumorigenesis, especially in the basal-like tumor
Kenta Shinha et al.
Micromachines, 11(7) (2020-07-28)
Numerous in vitro studies have been conducted in conventional static cell culture systems. However, most of the results represent an average response from a population of cells regardless of their local microenvironment. A microfluidic probe is a non-contact technology that
József Bocsi et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 61(1), 1-8 (2004-09-08)
Flow cytometry (FCM) and laser scanning cytometry (LSC) are the routine techniques for fluorescent cell analysis. Recently, we developed a scanning fluorescent microscopy (SFM) technique. This study compares SFM to LSC (two slide-based cytometry, SBC, techniques) and FCM, in experimental
Erich H Schneider et al.
Naunyn-Schmiedeberg's archives of pharmacology, 393(7), 1251-1267 (2020-04-22)
The effects of 100 μM of 3',5'-cGMP, cAMP, cCMP, and cUMP as well as of the corresponding membrane-permeant acetoxymethyl esters on anti-CD3-antibody (OKT3)-induced IL-2 production of HuT-78 cutaneous T cell lymphoma (Sézary lymphoma) cells were analyzed. Only 3',5'-cGMP significantly reduced IL-2
Galit Katarivas Levy et al.
Journal of clinical medicine, 8(10) (2019-09-25)
There is currently an interest in "active" implantable biomedical devices that include mechanical stimulation as an integral part of their design. This paper reports the experimental use of a porous scaffold made of interconnected networks of slender ferromagnetic fibers that
Adrian Fischer et al.
Nature communications, 11(1), 3068-3068 (2020-06-20)
Surgical adhesions are bands of scar tissues that abnormally conjoin organ surfaces. Adhesions are a major cause of post-operative and dialysis-related complications, yet their patho-mechanism remains elusive, and prevention agents in clinical trials have thus far failed to achieve efficacy.
Hiroki Kannen et al.
International journal of molecular sciences, 15(7), 11234-11244 (2014-06-27)
Recently, combined therapy using chemotherapy and photodynamic therapy (PDT) has been proposed as a means of improving treatment outcomes. In order to evaluate the efficacy of combined therapy, it is necessary to determine the distribution of the anticancer drug and
Yusuke Higashi et al.
Cellular signalling, 57, 10-20 (2019-02-05)
Minocycline, a tetracycline antibiotic, is known to exert vasculoprotective effects independent of its anti-bacterial properties; however the underlying molecular mechanisms are not completely understood. Reversion Inducing Cysteine Rich Protein with Kazal Motifs (RECK) is a cell surface expressed, membrane anchored
Jolanta Kamińska et al.
Advances in medical sciences, 64(2), 274-279 (2019-03-23)
In vitro expansion is an invaluable method to obtain keratinocytes in amounts necessary for effective transplantation therapies. In vitro cell culturing provokes questions concerning potential epigenetic alterations occurring in expanded cells in the context of usefulness for transplantation and safety.
Liqin Cao et al.
PLoS genetics, 5(12), e1000756-e1000756 (2009-12-10)
In mammals, observations of rapid shifts in mitochondrial DNA (mtDNA) variants between generations have led to the creation of the bottleneck theory for the transmission of mtDNA. The bottleneck could be attributed to a marked decline of mtDNA content in
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Ann Kristin Hansen et al.
BMC musculoskeletal disorders, 18(1), 432-432 (2017-11-08)
The aim was to investigate whether resident chondrocytes in human articular cartilage and in subculture express vitamin D receptor (VDR) and the enzyme that hydroxylates the prohormone 25(OH)D Cartilage from human osteoarthritic knee joints, cultured chondrocytes and cells grown in
Vibudha Nanduri et al.
Orthopaedic journal of sports medicine, 2(6), 2325967114539122-2325967114539122 (2014-06-01)
Articular cartilage (AC) injuries and malformations are commonly noticed because of trauma or age-related degeneration. Many methods have been adopted for replacing or repairing the damaged tissue. Currently available AC repair methods, in several cases, fail to yield good-quality long-lasting
Kara McNair et al.
Cancer biology & therapy, 20(3), 349-367 (2018-11-08)
Expression of the tumour suppressor Deleted in Colorectal Cancer (DCC) and the related protein neogenin is reduced by the mammalian serine protease chymotrypsin or the bacterial serine protease subtilisin, with increased cell migration. The present work examines whether these actions
Dong Li et al.
Cell cycle (Georgetown, Tex.), 16(11), 1070-1084 (2017-04-21)
Previous research has shown that a subpopulation of cells within cultured human dermal fibroblasts, termed multilineage-differentiating stress enduring (Muse) cells, are preferentially reprogrammed into induced pluripotent stem cells. However, controversy exists over whether these cells are the only cells capable
Biocompatibility of Ar plasma-treated fluorinated ethylene propylene: Adhesion and viability of human keratinocytes.
Lucie Peterková et al.
Materials science & engineering. C, Materials for biological applications, 100, 269-275 (2019-04-06)
Alena Shkumatava et al.
Genes & development, 23(4), 466-481 (2009-02-26)
MicroRNAs (miRNAs) are small noncoding RNAs that direct post-transcriptional repression of protein-coding genes. In vertebrates, each highly conserved miRNA typically regulates hundreds of target mRNAs. However, the precise relationship between expression of the miRNAs and that of their targets has
Eneko Axpe et al.
PloS one, 9(1), e83838-e83838 (2014-01-07)
Positron annihilation lifetime spectroscopy (PALS) provides a direct measurement of the free volume void sizes in polymers and biological systems. This free volume is critical in explaining and understanding physical and mechanical properties of polymers. Moreover, PALS has been recently
Gamal M K Mehaisen et al.
PloS one, 12(2), e0172684-e0172684 (2017-02-25)
The massive meat production of broiler chickens make them continuously exposed to potential stressors that stimulate releasing of stress-related hormones like corticosterone (CORT) which is responsible for specific pathways in biological mechanisms and physiological activities. Therefore, this research was conducted
Sebastian Strauss et al.
Nature methods, 15(9), 685-688 (2018-08-22)
Although current implementations of super-resolution microscopy are technically approaching true molecular-scale resolution, this has not translated to imaging of biological specimens, because of the large size of conventional affinity reagents. Here we introduce slow off-rate modified aptamers (SOMAmers) as small
Lucia Rutigliano et al.
Stem cell research & therapy, 4(5), 133-133 (2014-01-11)
While amniotic mesenchymal cells have been isolated and characterized in different species, amniotic epithelial cells (AECs) have been found only in humans and horses and are recently considered valid candidates in regenerative medicine. The aim of this work is to
Ivan Crespo-Enriquez et al.
Development (Cambridge, England), 146(14) (2019-07-31)
In human, mutations of the protocadherins FAT4 and DCHS1 result in Van Maldergem syndrome, which is characterised, in part, by craniofacial abnormalities. Here, we analyse the role of Dchs1-Fat4 signalling during osteoblast differentiation in mouse. We show that Fat4 and
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