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t3934

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Accumulation of citrullinated proteins by up-regulated peptidylarginine deiminase 2 in brains of scrapie-infected mice: a possible role in pathogenesis.

Byungki Jang et al.

The American journal of pathology, 173(4), 1129-1142 (2008-09-13)

Peptidylarginine deiminases (PADs), which are a group of posttranslational modification enzymes, are involved in protein citrullination (deimination) by the conversion of peptidylarginine to peptidylcitrulline in a calcium concentration-dependent manner. Among the PADs, PAD2 is widely distributed in various tissues and

Novel roles for A-type lamins in telomere biology and the DNA damage response pathway.

Ignacio Gonzalez-Suarez et al.

The EMBO journal, 28(16), 2414-2427 (2009-07-25)

A-type lamins are intermediate filament proteins that provide a scaffold for protein complexes regulating nuclear structure and function. Mutations in the LMNA gene are linked to a variety of degenerative disorders termed laminopathies, whereas changes in the expression of lamins

Sumatriptan inhibits synaptic transmission in the rat midbrain periaqueductal grey.

Hyo-Jin Jeong et al.

Molecular pain, 4, 54-54 (2008-11-19)

There is evidence to suggest that the midbrain periaqueductal grey (PAG) has a role in migraine and the actions of the anti-migraine drug sumatriptan. In the present study we examined the serotonergic modulation of GABAergic and glutamatergic synaptic transmission in

An RNA-Binding Protein Secreted by a Bacterial Pathogen Modulates RIG-I Signaling.

Alessandro Pagliuso et al.

Cell host & microbe, 26(6), 823-835 (2019-11-26)

RNA-binding proteins (RBPs) perform key cellular activities by controlling the function of bound RNAs. The widely held assumption that RBPs are strictly intracellular has been challenged by the discovery of secreted RBPs. However, extracellular RBPs have been described in eukaryotes

Characterization of an MPS I-H knock-in mouse that carries a nonsense mutation analogous to the human IDUA-W402X mutation.

Dan Wang et al.

Molecular genetics and metabolism, 99(1), 62-71 (2009-09-16)

Here we report the characterization of a knock-in mouse model for the autosomal recessive disorder mucopolysaccharidosis type I-Hurler (MPS I-H), also known as Hurler syndrome. MPS I-H is the most severe form of alpha-l-iduronidase deficiency. alpha-l-iduronidase (encoded by the IDUA

Several novel nuclear envelope transmembrane proteins identified in skeletal muscle have cytoskeletal associations.

Gavin S Wilkie et al.

Molecular & cellular proteomics : MCP, 10(1), M110-M110 (2010-09-30)

Nuclear envelopes from liver and a neuroblastoma cell line have previously been analyzed by proteomics; however, most diseases associated with the nuclear envelope affect muscle. To determine whether muscle has unique nuclear envelope proteins, rat skeletal muscle nuclear envelopes were

Tobacco rattle virus 16-kilodalton protein encodes a suppressor of RNA silencing that allows transient viral entry in meristems.

Ana M Martín-Hernández et al.

Journal of virology, 82(8), 4064-4071 (2008-02-15)

RNA silencing is a host defense mechanism that limits the accumulation and spread of viruses in infected plants. Correspondingly, plant viruses encode suppressors of silencing. In the positive-strand RNA virus Tobacco rattle virus (TRV), the suppressor of silencing is a

Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers.

Tadeja Rezen et al.

BMC genomics, 10, 384-384 (2009-08-21)

Detoxification in the liver involves activation of nuclear receptors, such as the constitutive androstane receptor (CAR), which regulate downstream genes of xenobiotic metabolism. Frequently, the metabolism of endobiotics is also modulated, resulting in potentially harmful effects. We therefore used 1,4-Bis

Cognitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice.

J B Buchanan et al.

Psychoneuroendocrinology, 33(6), 755-765 (2008-04-15)

Peripheral immune stimulation as well as certain types of psychological stress increases brain levels of inflammatory cytokines such as interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor alpha (TNFalpha). We have demonstrated that aged mice show greater increases in central inflammatory

Rapid Dissemination and Monopolization of Viral Populations in Mice Revealed Using a Panel of Barcoded Viruses.

Broc T McCune et al.

Journal of virology, 94(2) (2019-11-02)

The gastrointestinal tract presents a formidable barrier for pathogens to initiate infection. Despite this barrier, enteroviruses, including coxsackievirus B3 (CVB3), successfully penetrate the intestine to initiate infection and spread systemically prior to shedding in stool. However, the effect of the

A comparison of leaf and petal senescence in wallflower reveals common and distinct patterns of gene expression and physiology.

Anna Marie Price et al.

Plant physiology, 147(4), 1898-1912 (2008-06-10)

Petals and leaves share common evolutionary origins but perform very different functions. However, few studies have compared leaf and petal senescence within the same species. Wallflower (Erysimum linifolium), an ornamental species closely related to Arabidopsis (Arabidopsis thaliana), provide a good

Possible roles of parathyroid hormone, 1.25(OH)2D3, and fibroblast growth factor 23 on genes controlling calcium metabolism across different tissues of the laying hen.

A Gloux et al.

Domestic animal endocrinology, 72, 106407-106407 (2020-02-02)

This study provides an integrative description of candidate gene expression across tissues involved in calcium (Ca) metabolism during the egg laying cycle, using the well-defined model of Ca supply as fine or coarse particles of calcium carbonate (CaCO3). Plasma and

Expression of DLK1 and MEG3 genes in porcine tissues during postnatal development.

Maria Oczkowicz et al.

Genetics and molecular biology, 33(4), 790-794 (2011-06-04)

The Drosophila-like homolog 1 (DLK1), a transmembrane signal protein similar to other members of the Notch/Delta/Serrate family, regulates the differentiation process in many types of mammalian cells. Callipyge sheep and DLK1 knockout mice are excellent examples of a fundamental role

Mixed infections of Pepino mosaic virus strains modulate the evolutionary dynamics of this emergent virus.

P Gómez et al.

Journal of virology, 83(23), 12378-12387 (2009-09-18)

Pepino mosaic virus (PepMV) is an emerging pathogen that causes severe economic losses in tomato crops (Solanum lycopersicum L.) in the Northern hemisphere, despite persistent attempts of control. In fact, it is considered one of the most significant viral diseases

Overexpression of EVE1, a novel ubiquitin family protein, arrests inflorescence stem development in Arabidopsis.

Hyun-Ju Hwang et al.

Journal of experimental botany, 62(13), 4571-4581 (2011-06-01)

In Arabidopsis, inflorescence stem formation is a critical process in phase transition from the vegetative to the reproductive state. Although inflorescence stem development has been reported to depend on the expression of a variety of genes during floral induction and

Channelrhodopsins of Volvox carteri are photochromic proteins that are specifically expressed in somatic cells under control of light, temperature, and the sex inducer.

Arash Kianianmomeni et al.

Plant physiology, 151(1), 347-366 (2009-07-31)

Channelrhodopsins are light-gated ion channels involved in the photoresponses of microalgae. Here, we describe the characterization of two channelrhodopsins, Volvox channelrhodopsin-1 (VChR1) and VChR2, from the multicellular green alga Volvox carteri. Both are encoded by nuclear single copy genes and

Immunization of Domestic Ducks with Live Nonpathogenic H5N3 Influenza Virus Prevents Shedding and Transmission of Highly Pathogenic H5N1 Virus to Chickens.

Alexandra Gambaryan et al.

Viruses, 10(4) (2018-04-05)

Wild ducks are known to be able to carry avian influenza viruses over long distances and infect domestic ducks, which in their turn infect domestic chickens. Therefore, prevention of virus transmission between ducks and chickens is important to control the

Differential expression of immune defences is associated with specific host-parasite interactions in insects.

Carolyn Riddell et al.

PloS one, 4(10), e7621-e7621 (2009-10-28)

Recent ecological studies in invertebrates show that the outcome of an infection is dependent on the specific pairing of host and parasite. Such specificity contrasts the long-held view that invertebrate innate immunity depends on a broad-spectrum recognition system. An important

EP2 receptor mediated cAMP release is augmented by PGF 2 alpha activation of the FP receptor via the calcium-calmodulin pathway.

A B Abera et al.

Cellular signalling, 22(1), 71-79 (2009-09-29)

Prostaglandins exert their effects on target cells by coupling to specific G protein-coupled receptors (GPCRs) that are often co-expressed in the same cells and use alternate and in some cases opposing intracellular signaling pathways. This study investigated the cross-talk that

Quantification of Cre-mediated recombination by a novel strategy reveals a stable extra-chromosomal deletion-circle in mice.

Wouter N Leonhard et al.

BMC biotechnology, 8, 18-18 (2008-02-27)

Inducible conditional knockout animals are widely used to get insight in the function of genes and the pathogenesis of human diseases. These models frequently rely on Cre-mediated recombination of sequences flanked by Lox-P sites. To understand the consequences of gene

Comparative genomic and transcriptomic characterization of the toxigenic marine dinoflagellate Alexandrium ostenfeldii.

Nina Jaeckisch et al.

PloS one, 6(12), e28012-e28012 (2011-12-14)

Many dinoflagellate species are notorious for the toxins they produce and ecological and human health consequences associated with harmful algal blooms (HABs). Dinoflagellates are particularly refractory to genomic analysis due to the enormous genome size, lack of knowledge about their

TGF beta Presence During IgE-dependent Sensitization Primes Mast Cells for Higher VEGF Production After Fc varepsilon RI Activation

Benitez-GJP, et al.

Open Allergy Journal, 2, 16-26 (2009)

TGF Presence During IgE-dependent Sensitization Primes Mast Cells for Higher VEGF Production After Fc RI Activation

Garrido

Open Allergy Journal (2009)

Phospholipase D activation is an early component of the salicylic acid signaling pathway in Arabidopsis cell suspensions.

Ondrej Krinke et al.

Plant physiology, 150(1), 424-436 (2009-03-24)

Salicylic acid (SA) plays a central role in defense against pathogen attack, as well as in germination, flowering, senescence, and the acquisition of thermotolerance. In this report we investigate the involvement of phospholipase D (PLD) in the SA signaling pathway.

PPARγ deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects.

Michael J Kraakman et al.

The Journal of clinical investigation, 128(6), 2600-2612 (2018-03-29)

Thiazolidinediones (TZDs) are PPARγ agonists with potent insulin-sensitizing effects. However, their use has been curtailed by substantial adverse effects on weight, bone, heart, and hemodynamic balance. TZDs induce the deacetylation of PPARγ on K268 and K293 to cause the browning

Cell cycle control and DNA damage response of conditionally immortalized urothelial cells.

Bradley P Dixon et al.

PloS one, 6(1), e16595-e16595 (2011-02-10)

Children with complex urogenital anomalies often require bladder reconstruction. Gastrointestinal tissues used in bladder augmentations exhibit a greatly increased risk of malignancy, and the bladder microenvironment may play a role in this carcinogenesis. Investigating the influences of the bladder microenvironment

MicroRNA-125a is over-expressed in insulin target tissues in a spontaneous rat model of Type 2 Diabetes.

Blanca M Herrera et al.

BMC medical genomics, 2, 54-54 (2009-08-20)

MicroRNAs (miRNAs) are non-coding RNA molecules involved in post-transcriptional control of gene expression of a wide number of genes, including those involved in glucose homeostasis. Type 2 diabetes (T2D) is characterized by hyperglycaemia and defects in insulin secretion and action

Comparison of vascular endothelial growth factor and fibroblast growth factor-2 in a swine model of endothelial dysfunction.

Munir Boodhwani et al.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 33(4), 645-650 (2008-01-19)

Growth factor based angiogenesis, with or without cell therapy, is a promising therapeutic modality for patients with coronary artery disease. We compared the relative efficacies of surgically delivered vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2) in a

The effect of a new direct Factor Xa inhibitor on human osteoblasts: an in-vitro study comparing the effect of rivaroxaban with enoxaparin.

Gandhi N Solayar et al.

BMC musculoskeletal disorders, 12, 247-247 (2011-11-01)

Current treatments for the prevention of thromboembolism include heparin and low-molecular weight heparins (LMWHs). A number of studies have suggested that long term administration of these drugs may adversely affect osteoblasts and therefore, bone metabolism. Xarelto™ (Rivaroxaban) is a new

Breast cancer cells stimulate osteoprotegerin (OPG) production by endothelial cells through direct cell contact.

Penny E Reid et al.

Molecular cancer, 8, 49-49 (2009-07-17)

Angiogenesis, the sprouting of capillaries from existing blood vessels, is central to tumour growth and progression, however the molecular regulation of this process remains to be fully elucidated. The secreted glycoprotein osteoprotegerin (OPG) is one potential pro-angiogenic factor, and clinical

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