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Zeynep Kalkan et al.
Neuroscience letters, 620, 62-69 (2016-03-29)
Autism is one of the most common subtypes of autism spectrum disorder (ASD). Recent studies suggested a relationship between immune-dependent coding genes and ASD, indicating that long term neuroimmunological anomalies affect brain development and synaptic transmission among neural networks. Furthermore
Jan Vrbsky et al.
PloS one, 10(6), e0127739-e0127739 (2015-06-04)
The possibility of replacing the originally discovered and widely used DNA reprogramming transcription factors is stimulating enormous effort to identify more effective compounds that would not alter the genetic information. Here, we describe the generation of induced pluripotent stem cells
S Casabella et al.
The Analyst, 141(2), 689-696 (2015-11-21)
In recent years, significant progress has been made into the label-free detection and discrimination of individual cancer cells using Laser Tweezers Raman Spectroscopy (LTRS). However, the majority of examples reported have involved manual trapping of cells, which is time consuming
Matthew A Wozniak et al.
PloS one, 6(10), e25152-e25152 (2011-10-18)
Alzheimer's disease (AD) afflicts around 20 million people worldwide and so there is an urgent need for effective treatment. Our research showing that herpes simplex virus type 1 (HSV1) is a risk factor for AD for the brains of people
Soshana Svendsen et al.
BMC cell biology, 9, 17-17 (2008-04-04)
The ability to specifically label proteins within living cells can provide information about their dynamics and function. To study a membrane protein, we fused a multi-functional reporter protein, HaloTag, to the extracellular domain of a truncated integrin. Using the HaloTag
Ranjita Sengupta et al.
Biological procedures online, 18, 14-14 (2016-07-13)
A number of integrase defective lentiviral (IDLV) packaging systems have been developed to produce integration deficient lentiviruses for gene delivery and epichromosomal expression. However, despite their growing demand, a comparative study to systemically evaluate the performance efficiency of different mutants
Kaja Lund et al.
Journal of experimental & clinical cancer research : CR, 36(1), 187-187 (2017-12-21)
Development of resistance to 5-fluorouracil (5-FU) is a major problem in treatment of various cancers including pancreatic cancer. In this study, we reveal important resistance mechanisms and photochemical strategies to overcome 5-FU resistance in pancreatic adenocarcinoma. 5-FU resistant (5-FUR), epithelial-to-mesenchymal-like
Laurence Crombez et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 17(1), 95-103 (2008-10-30)
RNA interference constitutes a powerful tool for biological studies, but has also become one of the most challenging therapeutic strategies. However, small interfering RNA (siRNA)-based strategies suffer from their poor delivery and biodistribution. Cell-penetrating peptides (CPPs) have been shown to
Sanjay Jain et al.
Kidney international, 86(5), 1049-1055 (2014-04-25)
Single-cell genomics will enable studies of the earliest events in kidney development, although it is unclear if existing technologies are mature enough to generate accurate and reproducible data on kidney progenitors. Here we designed a pilot study to validate a
Christian Boehler et al.
Scientific reports, 6, 19574-19574 (2016-01-23)
On-demand release of bioactive substances with high spatial and temporal control offers ground-breaking possibilities in the field of life sciences. However, available strategies for developing such release systems lack the possibility of combining efficient control over release with adequate storage
Gábor Földes et al.
Journal of molecular and cellular cardiology, 50(2), 367-376 (2010-11-05)
Human embryonic stem cell-derived cardiomyocytes (hESC-CM) are being developed for tissue repair and as a model system for cardiac physiology and pathophysiology. However, the signaling requirements of their growth have not yet been fully characterized. We showed that hESC-CM retain
Victoria Klepsch et al.
Nature communications, 9(1), 1538-1538 (2018-04-20)
Analyzing mouse tumor models in vivo, human T cells ex vivo, and human lung cancer samples, we provide direct evidence that NR2F6 acts as an immune checkpoint. Genetic ablation of Nr2f6, particularly in combination with established cancer immune checkpoint blockade
Katrin Kleinmanns et al.
EBioMedicine, 56, 102782-102782 (2020-05-27)
The survival rate of patients with advanced high-grade serous ovarian carcinoma (HGSOC) remains disappointing. Clinically translatable orthotopic cell line xenograft models and patient-derived xenografts (PDXs) may aid the implementation of more personalised treatment approaches. Although orthotopic PDX reflecting heterogeneous molecular
Linna Zhou et al.
Advanced materials (Deerfield Beach, Fla.), 32(31), e2002183-e2002183 (2020-06-17)
Current understanding of human brain development is rudimentary due to suboptimal in vitro and animal models. In particular, how initial cell positions impact subsequent human cortical development is unclear because experimental spatial control of cortical cell arrangement is technically challenging.
Anika Schopf et al.
Bioelectrochemistry (Amsterdam, Netherlands), 109, 41-48 (2016-01-18)
Direct current (DC) stimulation can be used to influence the orientation and migratory behavior of cells and results in cellular electrotaxis. Experimental work on such phenomena commonly relies on electrochemical dissolution of silver:silver-chloride (Ag:AgCl) electrodes to provide the stimulation via
Yun Li et al.
Neuron, 59(3), 399-412 (2008-08-15)
Adult hippocampal neurogenesis is stimulated by chronic administration of antidepressants (ADs) and by voluntary exercise. Neural progenitor cells (NPCs) in the dentate gyrus (DG) that are capable of continuous proliferation and neuronal differentiation are the source of such structural plasticity.
Shuuji Mawaribuchi et al.
Biochemical and biophysical research communications, 515(1), 176-182 (2019-05-28)
The recombinant lectin rBC2LCN is a useful marker for discriminating the undifferentiated status of human induced or embryonic stem cells. Recently, rBC2LCN has also been used for detecting some cancers and niche cells. However, the generality of which types of
Annemiek M C P Joosen et al.
Carcinogenesis, 30(8), 1402-1407 (2009-06-06)
Haem in red meat (RM) stimulates the endogenous production of mutagenic nitroso compounds (NOC). Processed (nitrite-preserved red) meat additionally contains high concentrations of preformed NOC. In two studies, of a fresh RM versus a vegetarian (VEG) diet (six males and
Georg Jocher et al.
Frontiers in cellular neuroscience, 12, 166-166 (2018-07-03)
Neurons are morphologically the most complex cell types and are characterized by a significant degree of axonal autonomy as well as having efficient means of communication between axons and neuronal cell bodies. For studying the response to axonal injury, compartmentalized
Ashraf Hassanpour et al.
Stem cell research & therapy, 9(1), 252-252 (2018-09-28)
The increasing number of patients with ovarian insufficiency due to autoimmune disorders, genetic predisposition, or iatrogenic effects of treatment such as cancer therapies necessitates an urgent measure to find a safe and transplantable alternative ovary. A bioengineered ovary is one
Alberto Barbiroli et al.
Biomolecules, 9(10) (2019-10-17)
The search for bioactivities influencing the human wellbeing of food proteins and peptides is a topic of broad and current interest. γ-Conglutin (γC) is a lupin seed protein drawing remarkable pharmacological and/or nutraceutical interest, as it is able to reduce
Mária Szatmári-Tóth et al.
International journal of molecular sciences, 20(4) (2019-02-23)
Inefficient removal of dying retinal pigment epithelial (RPE) cells by professional phagocytes can result in debris formation and development of age-related macular degeneration (AMD). Chronic oxidative stress and inflammation play an important role in AMD pathogenesis. Only a few well-established
Florentina Negoita et al.
Biochemical and biophysical research communications, 508(3), 775-779 (2018-12-12)
Dysregulation of autophagy has been observed in obesity and type 2 diabetes. Salt-inducible kinase 2 (SIK2), a member of the AMPK-related kinase family, is downregulated in adipocytes from obese or insulin resistant individuals and was previously demonstrated to regulate autophagy
Michael Morgen et al.
ChemMedChem, 15(13), 1163-1174 (2020-04-30)
We report the synthesis and evaluation of a class of selective multitarget agents for the inhibition of HDAC6, HDAC8, and HDAC10. The concept for this study grew out of a structural analysis of the two selective inhibitors Tubastatin A (HDAC6/10) and
Parameet Kumar et al.
Respiratory research, 20(1), 284-284 (2019-12-18)
Recent advances in the functional analyses of endogenous non-coding RNA (ncRNA) molecules, including long non-coding RNAs (LncRNAs), have provided a new perspective on the crucial roles of RNA in gene regulation. Consequently, LncRNA deregulation is a key factor in various
Xiang Lin et al.
International journal of biological sciences, 7(8), 1114-1121 (2011-09-20)
Although the fibroblast growth factor (FGF) signaling axis plays important roles in cell survival, proliferation, and differentiation, the molecular mechanism underlying how the FGF elicits these diverse regulatory signals is not well understood. By using the Frs2α null mouse embryonic
Alexis Rossignol et al.
mAbs, 9(3), 521-535 (2017-03-11)
Standardized and biologically relevant potency assays are required by the regulatory authorities for the characterization and quality control of therapeutic antibodies. As critical mechanisms of action (MoA) of antibodies, the antibody-dependent cell-meditated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) must be
Shiva Hamidian Jahromi et al.
Stem cells and development, 27(1), 44-54 (2017-11-11)
Tumor necrosis factor alpha (TNF-α) induced protein 6 is a major anti-inflammatory mediator released by activated mesenchymal stromal cells (MSCs). Neonatal MSCs are considered more metabolically active than cells derived from adult tissues, and potentially less heterogeneous. We hypothesized that
Céline Riegert et al.
Brain research bulletin, 76(4), 439-453 (2008-05-27)
Serotonergic modulation of acetylcholine (ACh) release after neuron-specific increase of the expression of 5-HT(1B) receptors by gene transfer was studied in vitro and in vivo. The increased expression of the 5-HT(1B) receptor in vitro was induced by treating rat primary
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