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Showing 1-30 of 108 results for "

t0800000

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Safwan Abdel Rahim et al.
Pharmaceutical development and technology, 18(5), 1089-1100 (2012-07-11)
The aim of this work was to investigate the effect of ethanol on the in vitro swelling and release behaviors of Carbopol(®)-based tablets. The swelling behavior of drug-free compacts and the release of model drugs (metformin HCl, caffeine and theophylline)
Rui-Qiang Wang et al.
Molecular biology reports, 40(4), 3409-3418 (2012-12-26)
The interaction between ovalbumin (OVA) and three purine alkaloids (caffeine, theophylline and diprophylline) was investigated by the aid of intrinsic and synchronous fluorescence, ultraviolet-vis absorbance, resonance light-scattering spectra and three-dimensional fluorescence spectra techniques. Results showed that the formation of complexes
R Nageswara Rao et al.
Journal of pharmaceutical and biomedical analysis, 78-79, 211-216 (2013-03-19)
A rapid and highly sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for determination of doxofylline on rat dried blood spots and urine was developed and validated. The chromatographic separation was achieved on a reverse phase C18 column (250 mm ×
J Siepmann et al.
International journal of pharmaceutics, 441(1-2), 826-834 (2012-12-25)
Three mathematical models were applied to quantify drug release from HPMC/lactose-based matrix tablets loaded with varying amounts of theophylline: (i) a numerical model considering drug diffusion in axial and radial direction in cylinders as well as limited drug solubility effects
A K H Tee et al.
The Cochrane database of systematic reviews, (3)(3), CD001281-CD001281 (2007-07-20)
Theophylline and long acting beta-2 agonists are bronchodilators used for the management of persistent asthma symptoms, especially nocturnal asthma. They represent different classes of drug with differing side-effect profiles. To assess the comparative efficacy, safety and side-effects of long-acting beta-2
Wen-Hui Zhang et al.
Fundamental & clinical pharmacology, 26(1), 118-134 (2011-11-03)
Chronic obstructive pulmonary disease (COPD) has become a global epidemic disease with an increased morbidity and mortality in the world. Inflammatory process progresses and contributes to irreversible airflow limitation. However, there is no available therapy to better control the inflammatory
Kaoru Nagai
Neurotoxicology and teratology, 48, 33-39 (2015-01-27)
Phytanic acid is a branched fatty acid that is a metabolic intermediate of chlorophyll. In this study, the effects of phytanic acid on Histone deacetylase (Hdac) activity were examined in an in vitro enzyme assay and in neuronal Neuro2a cells.
N Inui et al.
Clinical pharmacology and therapeutics, 94(6), 702-708 (2013-08-27)
Cytochrome P450 (CYP) 1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A are major factors involved in the metabolism of clinically prescribed drugs. Because the time course after drug treatment discontinuation has received little attention, we aimed to clarify the chronological changes of
Manja Wachsmuth et al.
Nucleic acids research, 41(4), 2541-2551 (2013-01-01)
Riboswitches are regulatory RNA elements typically located in the 5'-untranslated region of certain mRNAs and control gene expression at the level of transcription or translation. These elements consist of a sensor and an adjacent actuator domain. The sensor usually is
Peter J Barnes
Proceedings of the American Thoracic Society, 2(4), 334-339 (2005-11-04)
Although theophylline has side effects when used in bronchodilator doses, increasing evidence shows that it has significant antiinflammatory effects in chronic obstructive pulmonary disease at lower plasma concentrations. These antiinflammatory effects are unlikely to be accounted for by phosphodiesterase inhibition
Anja Veronovski et al.
International journal of pharmaceutics, 454(1), 58-66 (2013-07-16)
The presented research was oriented towards the preparation of dry biodegradable alginate aerogels with multi-membranes using a multi-step sol-gel process with potential applications as carriers during oral drug delivery. First alginate spherical hydrogels were formed in CaCl2 or BaCl2 solutions
Masato Muraki et al.
Drug delivery, 21(5), 321-327 (2013-10-24)
The systemic administration of theophylline is useful for asthma treatment. However its narrow therapeutic range makes it difficult to use. Little is known about its potential in inhalation therapy, particularly repeated inhalation. The purpose of this study is to investigate
Nicola Carano et al.
Pediatrics, 131(4), e1280-e1283 (2013-03-20)
Severe pallid breath-holding spells (BHSs) are based on parasympathetic hyperactivity, leading to cardiac asystole, pallor, brain ischemia, loss of consciousness, and reflex anoxic seizures. In recent years, an increasing number of patients with severe pallid BHSs have been successfully treated
Fahad I Al-Jenoobi et al.
Pharmaceutical biology, 53(2), 296-300 (2014-09-23)
Herb-drug interactions are a serious problem especially for drugs with a narrow therapeutic index, taking into consideration that herbal medicines are commonly used in various parts of the world. The present study investigates the effect of fenugreek, garden cress, and
Jiraporn Ousingsawat et al.
Nature communications, 6, 6245-6245 (2015-02-06)
Purinergic P2X7 receptors (P2X7R) are fundamental to innate immune response. In macrophages, transient stimulation of P2X7R activates several transport mechanisms and induces the scrambling of phospholipids with subsequent membrane blebbing and apoptosis. These processes support phagocytosis and subsequent killing of
Aranya Manosroi et al.
Journal of biomedical nanotechnology, 9(4), 626-638 (2013-04-30)
The objective of this study was to compare the charge effect of methyl myristate loaded in neutral (Brij 72/cholesterol at 7:3), cationic (Brij 72/cholesterol/dimethyl dioctadecyl ammonium bromide at 7:3:0.65) and anionic niosomes (Brij 72/cholesterol/dicetyl phosphate at 7:3:0.65) for physicochemical characteristics
Yong-jian Xu
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 26(3), 319-322 (2004-07-23)
Theophylline has been reduced usage in asthma and chronic obstructive pulmonary disease because of the high frequency of side effects and the relatively low efficacy. However, recent researches have demonstrated that low-dose theophylline can not only relax airway smooth muscle
Hanxiang Nie et al.
Respiratory medicine, 107(3), 347-354 (2013-01-08)
To compare the efficacy of theophylline plus salmeterol/fluticasone propionate combination product (SFC) with SFC plus placebo in asthmatic patients. In this randomized, stratified, parallel-group study, 325 patients were randomized to receive either 200 mg theophylline plus 50/250 μg SFC or placebo tablet
K Radke et al.
Der Anaesthesist, 62(2), 149-161 (2013-02-13)
Headache following dural puncture is a typical complication of neuraxial analgesia and can impair the ability to perform activities of daily living up to incapacitation. The use of thin, atraumatic needles and special puncture techniques (e.g. reinsertion of the stylet)
Stéphanie Romand et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 14-21 (2014-07-06)
A capillary isoelectric focusing (cIEF) method was developed for the determination of the ionization constants (pKa) of small molecules. Two approaches used to decrease the electroosmotic flow (EOF) were compared: (i) a hydroxypropylcellulose (HPC) coated capillary in aqueous medium and
Vidya Perera et al.
The Journal of pharmacy and pharmacology, 65(2), 264-270 (2013-01-03)
Response to some medications can depend on time of administration throughout the day. This study investigated diurnal variation in cytochrome P450 1A2 (CYP1A2) activity in people of South Asian and European ancestry. CYP1A2 activity was determined using the 4-h paraxanthine/caffeine
Anne-Laure Gassner et al.
Journal of chromatography. A, 1353, 121-130 (2014-06-14)
Procedures for estimating the measurement uncertainty (MU) of the concentration of a given analyte in a sample are of major concern for analytical chemists. Unfortunately, it is still unclear how and why MU should be assessed. While several possibilities exist
Hossein Vakili et al.
International journal of pharmaceutics, 483(1-2), 244-249 (2014-12-21)
The aim of the study was to investigate applicability of near infra-red (NIR) hyperspectral imaging technique in quality control of printed personalised dosage forms. Inkjet printing technology was utilized to fabricate escalating doses of an active pharmaceutical ingredient (API). A
Ahmet Karakeci et al.
Urology, 82(3), 625-629 (2013-08-31)
To evaluate the early therapeutic alternatives such as bosentan, an endothelin receptor blocker, theophylline, an adenosin receptor blocker, and a nonselective phosphodiesterase enzyme inhibitor, zinc protoporphyrin (ZnPP), a heme oxygenase 1 inhibitor, for the therapy of ischemic priapism in the
Yu Fen Zheng et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 68, 117-127 (2014-03-19)
We evaluated the potential of BST204, a purified dry extract of ginseng, to inhibit or induce human liver cytochrome P450 enzymes (CYPs) and UDP-glucuronosyltransferases (UGTs) in vitro to assess its safety. In vitro drug interactions of four bioactive ginsenosides of
Felix S F Ram
Current opinion in pulmonary medicine, 12(2), 132-139 (2006-02-04)
The role of theophylline in the management of chronic obstructive pulmonary disease remains controversial. This review was undertaken to determine the efficacy of theophylline in patients with stable disease. Twenty-two good quality randomized controlled trials were included in this systematic
Kofi Asare-Addo et al.
Colloids and surfaces. B, Biointerfaces, 104, 54-60 (2013-01-10)
Theophylline extended release (ER) matrices containing hypromellose (hydroxypropyl methylcellulose (HPMC) E4M and K4M were evaluated in media with a pH range of 1.2-7.5, using an automated USP type III, Bio-Dis dissolution apparatus. The objectives of this study were to evaluate
Hazit Zayas et al.
Organic & biomolecular chemistry, 12(36), 6994-7003 (2014-06-17)
Six novel functional monomers: 4-(4-vinylphenyl)pyridine (M1), 4′-vinylbiphenyl-4-ol (M2), N,N-dimethyl-4′-vinylbiphenyl-3-amine (M3), (4′-vinylbiphenyl-4-yl)methanol (M4), 4′-vinylbiphenyl-4-carboxylic acid (M5) and 4-hydroxy-5-methyl-4′-vinylbiphenyl-3-carboxylic acid (M6), were examined for their ability to imprint theophylline (1). Using a molecular modelling-NMR titration approach, M2 and M6 were predicted to
Bing Dai et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 60(3), 360-370 (2012-04-21)
Whether treatment with adenosine receptor antagonists such as theophylline can prevent contrast-induced acute kidney injury (AKI) remains controversial. We conducted a meta-analysis of randomized controlled trials using MEDLINE (1966 to July 2011), EMBASE (1980 to July 2011), Web of Science
Mazen Al-Alawi et al.
The American journal of medicine, 127(5), 370-378 (2014-01-02)
Global estimates on aging predict an increased burden of asthma in the older population. Consequently, its recognition, diagnosis, and management in clinical practice require optimization. This review aims to provide an update for clinicians, highlighting advances in the understanding of
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