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William J Kraemer et al.
Journal of the American College of Nutrition, 34(2), 91-99 (2015-03-12)
This study evaluated whether a combination of whey protein (WP), calcium beta-hydroxy-beta-methylbutyrate (HMB), and carbohydrate exert additive effects on recovery from highly demanding resistance exercise. Thirteen resistance-trained men (age: 22.6 ± 3.9 years; height: 175.3 ± 12.2 cm; weight: 86.2 ± 9.8 kg)
Kerem Han Gözükara et al.
International urology and nephrology, 47(7), 1099-1103 (2015-05-08)
To investigate renal function in idiopathic hypogonadotropic hypogonadic (IHH) patients by measuring glomerular filtration rate (GFR) using modification of diet in renal disease formula, and determine whether there is any relationship between GFR and testosterone levels. Thirty-three patients with IHH
Yicong Bian et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(9), 1336-1340 (2015-06-14)
Minipigs represent a good animal model because of the physiologic and anatomic similarities they share with humans. Three cytochrome P450 (CYP) 3A isozymes, CYP3A22, CYP3A29, and CYP3A46, have recently been reported to be expressed in Bama minipigs, which have limited
Kaberi Acharia et al.
Indian journal of experimental biology, 52(5), 538-541 (2014-05-24)
In the present study, the female Clarias batrachus, held under long photoperiod (13L:11D), were exposed to high water temperature either constantly (24 h) and/or in form of thermopulse of 6 h and 12 h durations, separately, at different times of
María Salomé Gachet et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 976-977, 6-18 (2014-12-02)
Free arachidonic acid is functionally interlinked with different lipid signaling networks including those involving prostanoid pathways, the endocannabinoid system, N-acylethanolamines, as well as steroids. A sensitive and specific LC-MS/MS method for the quantification of arachidonic acid, prostaglandin E2, thromboxane B2
Sabrina Jarazo Dietrich et al.
PloS one, 10(6), e0128709-e0128709 (2015-06-06)
Although the testis is considered an immunoprivileged organ it can orchestrate immune responses against pathological insults such as infection and trauma. Experimental autoimmune orchitis (EAO) is a model of chronic inflammation whose main histopathological features it shares with human orchitis.
Ghasem Saki et al.
Noise & health, 15(64), 194-198 (2013-05-22)
The aims of this study were to evaluate the effects of administration of Vitamins C and E on fertilization capacity in rats exposed to noise stress. 40 adult male rats were randomly divided into 5 equal groups. Group 1 as
Darius A Paduch et al.
Urology, 83(5), 980-988 (2014-02-20)
The evaluation and treatment of hypogonadal men has become an important part of urologic practice. Fatigue, loss of libido, and erectile dysfunction are commonly reported, but nonspecific symptoms and laboratory verification of low testosterone (T) are an important part of
Rana R McKay et al.
Cancer, 121(15), 2603-2611 (2015-04-24)
Patients with biochemical disease recurrence (BCR) after definitive treatment for prostate cancer comprise a heterogeneous population for whom standard therapy options are lacking. The purpose of the current trial was to evaluate the feasibility, toxicity, and efficacy of early multimodality
Johanna S Archer et al.
Menopause (New York, N.Y.), 13(3), 528-537 (2006-06-01)
To determine the effect of estradiol and testosterone on brain-activation patterns in surgically postmenopausal women viewing erotic video clips using functional magnetic resonance imaging. Six women, who had undergone a bilateral oophorectomy and hysterectomy for benign disease, viewed erotic and
Alexis D Light et al.
Obstetrics and gynecology, 124(6), 1120-1127 (2014-11-22)
To conduct a cross-sectional study of transgender men who had been pregnant and delivered after transitioning from female-to-male gender to help guide practice and further investigation. We administered a web-based survey from March to December 2013 to inquire about demographics
Androgen levels and semen parameters among former users of finasteride with persistent sexual adverse effects.
Michael S Irwig
JAMA dermatology, 150(12), 1361-1363 (2014-09-18)
Silke Matysik et al.
Steroids, 99(Pt B), 151-154 (2015-02-07)
A fast and sensitive GC-MS/MS method is proposed to determine pregnenolone, dehydroepiandrosterone (DHEA), testosterone and dihydrotestosterone from human plasma. Steroids were extracted by liquid/liquid extraction, and derivatized with N-methyl-N-trimethylsilyl-trifluoracetamide. Electron ionization at 30eV was applied to generate high abundant precursor
Jonathan P Jarow et al.
Journal of andrology, 26(3), 343-348 (2005-05-04)
Little is known about how human spermatogenesis is regulated, so it is not surprising that there have been few breakthroughs in the treatment of male infertility resulting from abnormalities of spermatogenesis. Testosterone is the predominant intratesticular steroid in both the
Isaac A Adedara et al.
Pharmaceutical biology, 53(5), 695-704 (2014-09-23)
In Africa, Garcinia kola Heckel (Guttiferae) seed is commonly recommended in folklore medicine for the treatment of diabetes and its associated complications. The present study evaluated this traditional claim by mechanistic investigation into the effect of G. kola seed administration
Tiffany Greco et al.
Developmental neurobiology, 75(2), 193-202 (2014-07-30)
Adolescents are at greatest risk for traumatic brain injury (TBI) and repeat TBI (RTBI). TBI-induced hypopituitarism has been documented in both adults and juveniles and despite the necessity of pituitary function for normal physical and brain development, it is still
Brian Cunniffe et al.
International journal of sports physiology and performance, 10(6), 687-694 (2015-05-07)
This study evaluated the effect of game venue and starting status on precompetitive psychophysiological measures in elite rugby union. Saliva samples were taken from players (starting XV, n = 15, and nonstarters, n = 9) on a control day and
Inge Gies et al.
European journal of endocrinology, 171(2), R67-R77 (2014-05-08)
Klinefelter syndrome (KS) is the most common sex chromosomal disorder in males. Key findings in older adolescents and young men are small testes with variable hypo-androgenism, but almost universal azoospermia, most frequently in combination with a history of learning difficulties
Johanna Troberg et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(1), 107-118 (2014-10-11)
Understanding drug glucuronidation in the dog, a preclinical animal, is important but currently poorly characterized at the level of individual enzymes. We have constructed cDNAs for the 10 dog UDP-glucuronosyltransferases of subfamily 1A (dUGT1As), expressed them in insect cells, and
Evan Y Yu et al.
European urology, 67(2), 334-341 (2014-06-28)
A need remains for new therapeutic approaches for men with advanced prostate cancer, particularly earlier in the disease course. To assess the ability of an oral selective estrogen receptor α agonist (GTx-758) to lower testosterone concentrations compared with leuprolide while
David W Andersen et al.
Journal of analytical toxicology, 38(9), 637-644 (2014-08-12)
A screening method for 18 frequently measured exogenous anabolic steroids and the testosterone/epitestosterone (T/E) ratio in forensic cases has been developed and validated. The method involves a fully automated sample preparation including enzyme treatment, addition of internal standards and solid
Weihua Xiao et al.
Nutrients, 7(10), 8645-8656 (2015-10-28)
The aim of this study was to evaluate the effect of strenuous exercise on the functions of peritoneal macrophages in rats and to test the hypothesis that branched-chain amino acid (BCAA) supplementation will be beneficial to the macrophages of rats
M Z Allouh
International journal of impotence research, 27(3), 113-117 (2014-12-19)
Physical activity has long been associated with better sexual function. This study investigated the effects of moderate swimming exercise on the copulatory behavior of sexually potent male rats. Two sets of sexually potent male rats -highly active and moderately active-
Hana M Odeh et al.
Biology of reproduction, 90(6), 123-123 (2014-04-18)
We reported previously that stem cells associated with adult rat testis seminiferous tubules are able to give rise to differentiated Leydig cells in vitro. The regulatory mechanisms by which they do so, however, are uncertain. Herein, we hypothesized that the
Abigail E Russi et al.
Journal of immunology (Baltimore, Md. : 1950), 194(12), 5609-5613 (2015-05-15)
Multiple sclerosis preferentially affects women, and this sexual dimorphism is recapitulated in the SJL mouse model of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE). In this study, we demonstrate that signaling through c-Kit exerts distinct effects on EAE susceptibility in male
Tracy A Larson et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(39), 13066-13076 (2014-09-26)
Neuronal birth and death are tightly coordinated to establish and maintain properly functioning neural circuits. Disruption of the equilibrium between neuronal birth and death following brain injury or pharmacological insult often induces reactive, and in some cases regenerative, neurogenesis. Many
Mazen Shihan et al.
Biochimica et biophysica acta, 1843(6), 1172-1181 (2014-03-19)
Testosterone is known to mediate its effects by two different mechanisms of action. In the so-called "classical" pathway testosterone binds to cytosolic androgen receptors (AR), which essentially function as ligand-activated transcription factors. Once activated, these receptors bind to DNA and
Re: lower plasma testosterone or dihydrotestosterone, but not estradiol, is associated with symptoms of intermittent claudication in older men.
Allen D Seftel
The Journal of urology, 191(5), 1352-1352 (2014-04-22)
Jean-Christophe Pignon et al.
PloS one, 10(5), e0128489-e0128489 (2015-05-30)
There is evidence that stem cells and their progeny play a role in the development of the prostate. Although stem cells are also considered to give rise to differentiated progeny in the adult prostate epithelium ex vivo, the cohort of
Erik J J Duschek et al.
Maturitas, 51(3), 286-293 (2005-06-28)
In aging men serum levels of testosterone and insulin-like growth factor-1 (IGF-1) decline, potential factors in the reduced muscle strength, abdominal obesity, sexual dysfunction and impaired general well being of aging. The partial oestrogen agonist and antagonist raloxifene increase serum
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