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Eunyoung Han et al.
Forensic science international, 212(1-3), 238-241 (2011-08-02)
In this study, the concentrations of 11-nor-Δ(9)-tetrahydrocannabinol-9-carboxylic acid (THCCOOH) in pubic, axillary and beard hair were measured and the correlation between the concentrations of THCCOOH in head and pubic hair from same cannabis users were evaluated. The papers on body
Xiang He et al.
Analytical chemistry, 84(18), 7643-7647 (2012-08-21)
Oral fluid has been gaining more acceptance as the alternative matrix for forensic toxicology. Currently, Δ(9)-tetrahydrocannabinol (THC) is used as the primary target for detecting cannabis use in oral fluid. Meanwhile, THC carboxylic acid (THCA) in oral fluid is reported
Caroline Bylda et al.
Drug testing and analysis, 4(7-8), 668-674 (2012-03-01)
A fast and sensitive reference method for quantification of Δ(9) -tetrahydrocannabinol (THC) and its main metabolite 11-nor-9-carboxy-Δ(9) -tetrahydrocannabinol (THCCOOH) in oral fluid is described in this study. Samples were collected using an oral specimen collection device, followed by solid-phase extraction
Markus Joerger et al.
Drug metabolism letters, 6(2), 102-108 (2012-05-19)
Cannabinoids exert neuroprotective and symptomatic effects in amyotrophic lateral sclerosis (ALS). We assessed the pharmacokinetics (PK) and tolerability of delta-9-tetrahydrocannabinol (THC) in ALS patients. Nine patients received THC single oral doses of 5mg and 10mg, separated by a wash-out period
Michael G Holland et al.
Forensic science international, 212(1-3), 247-251 (2011-07-19)
Postmortem redistribution (PMR), a well-described phenomenon in forensic toxicology for certain drugs, can result in increased central blood concentrations relative to peripheral blood concentrations. Δ(9)-tetrahydrocannabinol (THC), the primary psychoactive component in cannabis or marijuana, is the illicit substance most commonly
Eunyoung Han et al.
Journal of analytical toxicology, 36(3), 195-200 (2012-03-16)
Cannabis is the most widely abused drug in the world. The purpose of this study is to detect 11-nor-9-carboxy-Δ⁹-tetrahydrocannabinol (THCCOOH) in segmental hair and to evaluate the patterns of cannabis use. We investigated the relationship between the concentrations of THCCOOH
Karl B Scheidweiler et al.
Clinical chemistry, 59(7), 1108-1117 (2013-03-23)
Blood and plasma cannabinoid stability is important for test interpretation and is best studied in authentic rather than fortified samples. Low and high blood and plasma pools were created for each of 10 participants after they smoked a cannabis cigarette.
Andreas R Baudy et al.
The Journal of pharmacology and experimental therapeutics, 343(1), 225-232 (2012-06-30)
Glucocorticoids are standard of care for many inflammatory conditions, but chronic use is associated with a broad array of side effects. This has led to a search for dissociative glucocorticoids--drugs able to retain or improve efficacy associated with transrepression [nuclear
Marie Fabritius et al.
Forensic science international, 223(1-3), 114-118 (2012-09-18)
The metabolism of Δ(9)-tetrahydrocannabinol (THC) is relatively complex, and over 80 metabolites have been identified. However, much less is known about the formation and fate of cannabinoid conjugates. Bile excretion is known to be an important route for the elimination
A Mendoza et al.
Environment international, 70, 76-87 (2014-06-09)
This work analyzes the seasonal variation (winter and summer) of ten drugs of abuse, six metabolites and three benzodiazepines in surface waters from the Jarama and Manzanares Rivers in the Madrid Region, the most densely populated area in Spain. The
M Minoli et al.
Forensic science international, 218(1-3), 49-52 (2011-11-01)
The fine detection of 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid (THCCOOH) in hair matrix remains one of the most important topics in hair analysis. This relevance lies in the necessity to obtain evidence of effective drug consumption and dispel any doubt of environmental contamination.
Carsten Rygaard Hjorthøj et al.
Addiction (Abingdon, England), 107(6), 1123-1131 (2011-12-14)
To assess correlations and agreement between timeline follow-back (TLFB)-assisted self-report and blood samples for cannabis use. Secondary analysis of a randomized trial. Copenhagen, Denmark. One hundred and three patients from the CapOpus trial with cannabis use disorder and psychosis, providing
Cynthia Coulter et al.
Journal of analytical toxicology, 36(6), 413-417 (2012-04-26)
This paper describes the determination of tetrahydrocannabinol (THC) and its metabolite, 11-nor-Δ⁹-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) in oral fluid using solid-phase extraction and liquid chromatography with tandem mass spectral detection (LC-MS-MS) and its application to proficiency specimens. The method employs collection of
David M Schwope et al.
Journal of analytical toxicology, 36(6), 405-412 (2012-05-17)
Δ⁹-Tetrahydrocannabinol (THC) is the illicit drug most frequently observed in accident and driving under the influence of drugs investigations. Whole blood is often the only available specimen collected during such investigations, yet few studies have examined relationships between cannabis effects
Yannick Lecompte et al.
Journal of analytical toxicology, 36(8), 569-574 (2012-08-31)
The guidelines for screening of urinary cannabinoids require that all specimens testing positive should be confirmed by gas chromatography-mass spectrometry at a confirmatory test cutoff value of 15 ng/mL of 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THCCOOH). To assess the impact of lowering the confirmatory
Vanessa de M Prata et al.
Analytical and bioanalytical chemistry, 403(2), 625-632 (2012-03-01)
A new procedure is described for the derivatization by silylation of 11-nor-Δ(9)-tetrahydrocannabinol-9-carboxylic acid (THCCOOH) present in urine, followed by analysis using gas chromatography-tandem mass spectrometry. A conventional procedure for derivatization of the analyte was evaluated using two types of experimental
Iria González-Mariño et al.
Analytical chemistry, 84(3), 1708-1717 (2011-12-22)
For the first time, a mixed-mode solid-phase extraction with fractionation of basic analytes from neutral and acidic species during cartridge elution and liquid chromatography-quadrupole-time-of-flight mass spectrometry (LC-QTOF-MS) was combined for the quantitative determination of 24 illicit drugs and metabolites in
Christine Moore et al.
Forensic science international, 212(1-3), 227-230 (2011-07-19)
The concentration of tetrahydrocannabinol (THC) and its main metabolite 11-nor-Δ(9)-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) as well as cannabinol (CBN), and cannabidiol (CBD) were measured in oral fluid following realistic exposure to marijuana in a Dutch coffee-shop. Ten healthy subjects, who were not
Nathalie A Desrosiers et al.
Clinical chemistry, 60(4), 631-643 (2014-02-25)
Δ(9)-Tetrahydrocannabinol (THC), 11-hydroxy-THC (11-OH-THC), and 11-nor-9-carboxy-THC (THCCOOH) have been reported in blood from frequent cannabis smokers for an extended time during abstinence. We compared THC, 11-OH-THC, THCCOOH, cannabidiol, cannabinol, THC-glucuronide, and 11-nor-9-carboxy-THC-glucuronide (THCCOO-glucuronide) blood and plasma disposition in frequent and
Mateus M Bergamaschi et al.
Clinical chemistry, 59(3), 519-526 (2013-03-02)
Cannabis is the illicit drug most frequently reported with impaired driving and motor vehicle accidents. Some "per se" laws make it illegal to drive with any amount of drug in the body, while others establish blood, saliva, or urine concentrations
Gabriele Zanchetti et al.
Journal of mass spectrometry : JMS, 47(1), 124-130 (2012-01-28)
A method for the rapid and robust confirmation of 11-nor-∆9-tetrahydrocannabinol-9-carboxylic acid (THCA) in urine involving basic hydrolysis with NaOH and direct injection of the hydrolysate in a column-switching LC-MS-MS system was developed and validated. THCA-d3 was used as internal standard.
Yoshiaki Iwamuro et al.
Biomedical chromatography : BMC, 26(11), 1452-1456 (2012-03-16)
Δ(9) -Tetrahydrocannabinol is the primary psychoactive component in cannabis, one of the most commonly used illicit drugs in the world. This paper describes a simple and rapid method for direct analysis of major metabolites of Δ(9) -tetrahydrocannabinol; 11-nor-Δ(9) -tetrahydrocannabinol-9-carboxylic acid
Nathalie A Desrosiers et al.
Clinical chemistry, 58(10), 1418-1425 (2012-08-23)
Oral fluid (OF) testing offers noninvasive sample collection for on-site drug testing; however, to date, test performance for Δ(9)-tetrahydrocannabinol (THC) detection has had unacceptable diagnostic sensitivity. On-site tests must accurately identify cannabis exposure because this drug accounts for the highest
David M Schwope et al.
Clinical chemistry, 57(10), 1406-1414 (2011-08-13)
Δ⁹-Tetrahydrocannabinol (THC) is the most frequently observed illicit drug in investigations of accidents and driving under the influence of drugs. THC-glucuronide has been suggested as a marker of recent cannabis use, but there are no blood data following controlled THC
Laura Mercolini et al.
Journal of pharmaceutical and biomedical analysis, 76, 119-125 (2013-01-12)
An advanced analytical method based on liquid chromatography-tandem mass spectrometry (LC-MS/MS), has been developed for the identification and determination in hair of Δ(9)-tetrahydrocannabinol together with its major metabolite 11-nor-9-carboxy-Δ(9)-tetrahydrocannabinol. Since the latter is formed endogenously, it allows the assessment of
Dayong Lee et al.
Clinical chemistry, 58(4), 748-756 (2012-01-26)
We measured Δ(9)-tetrahydrocannabinol (THC), 11-nor-9-carboxy-THC (THCCOOH), cannabidiol (CBD), and cannabinol (CBN) disposition in oral fluid (OF) following controlled cannabis smoking to evaluate whether monitoring multiple cannabinoids in OF improved OF test interpretation. Cannabis smokers provided written informed consent for this
Garry Milman et al.
Clinical chemistry, 57(11), 1597-1606 (2011-08-31)
Oral fluid (OF) testing is increasingly important for drug treatment, workplace, and drugged-driving programs. There is interest in predicting plasma or whole-blood concentrations from OF concentrations; however, the relationship between these matrices is incompletely characterized because of few controlled drug-administration
Stefan W Toennes et al.
Journal of pharmaceutical and biomedical analysis, 140, 215-222 (2017-04-04)
Each year, synthetic cannabinoids are occurring in high numbers in the illicit drug market, but data on their pharmacology and toxicology are scarcely available. Therefore, a pilot study was performed to assess adverse effects of JWH-018, which is one of
Eleftherios Vairaktaris et al.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 104(6), 796-802 (2007-04-13)
The present study was performed to investigate the possible association of -590 C/T polymorphism in the interleukin-4 (IL-4) gene which affects its expression with the risk for development of oral cancer. Polymerase chain reaction-based restriction analysis was performed in DNA
Thomas C Krivak et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 26(21), 3598-3606 (2008-07-22)
We hypothesized that common polymorphisms in excision repair cross-complementation group 1 (ERCC1), involved in nucleotide excision repair of platinum-induced damage, would be associated with progression-free survival (PFS) and overall survival (OS) in women with optimally resected, stage III epithelial ovarian
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