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Extracellular matrices and cell adhesion.
E Ruoslahti et al.
Arteriosclerosis (Dallas, Tex.), 5(6), 581-594 (1985-11-01)
Matthew P Keasey et al.
Cell communication and signaling : CCS, 11, 35-35 (2013-05-23)
Ciliary neurotrophic factor (CNTF) expression is repressed in astrocytes by neuronal contact in the CNS and is rapidly induced by injury. Here, we defined an inhibitory integrin signaling pathway. The integrin substrates laminin, fibronectin and vitronectin, but not collagen, thrombospondin
Vitronectin expression in the airways of subjects with asthma and chronic obstructive pulmonary disease.
Salazar-Pelaez LM, et al.
PLoS ONE, 10, e0119717-e0119717 (2015)
Johanna Hutterer et al.
Analytical and bioanalytical chemistry (2021-07-18)
The understanding of the initial cell adhesion to biomaterials is crucial for the survival of implants. The manifold possibilities to tailor an implant surface and the diverse requirements for different implant applications necessitate a timesaving and highly parallelized analytical methodology.
Michael Bachmann et al.
Journal of cell science, 133(9) (2020-03-21)
αVβ3 integrin can bind to multiple extracellular matrix proteins, including vitronectin (Vn) and fibronectin (Fn), which are often presented to cells in culture as homogenous substrates. However, in tissues, cells experience highly complex and changing environments. To better understand integrin
Carine Ysebaert et al.
Infection and immunity, 87(8) (2019-05-22)
PE-PilA is a fusion protein composed of immunologically relevant parts of protein E (PE) and the majority subunit of the type IV pilus (PilA), two major antigens of nontypeable Haemophilus influenzae (NTHi). Here we report on the preclinical evaluation of
Arthur H Cheng et al.
Cell reports, 26(12), 3191-3202 (2019-03-21)
Clock neurons within the mammalian suprachiasmatic nuclei (SCN) encode circadian time using interlocked transcription-translation feedback loops (TTFLs) that drive rhythmic gene expression. However, the contributions of other transcription factors outside of the circadian TTFLs to the functionality of the SCN
Tom Flossmann et al.
Cell reports, 26(12), 3173-3182 (2019-03-21)
Synchronized activity is a universal characteristic of immature neural circuits that is essential for their developmental refinement and strongly depends on GABAergic neurotransmission. A major subpopulation of GABA-releasing interneurons (INs) expresses somatostatin (SOM) and proved critical for rhythm generation in
Denise Salzig et al.
Stem cells international, 2016, 5246584-5246584 (2016-03-24)
The manufacture of human mesenchymal stem cells (hMSCs) for clinical applications requires an appropriate growth surface and an optimized, preferably chemically defined medium (CDM) for expansion. We investigated a new protein/peptide-free CDM that supports the adhesion, growth, and detachment of
Vitronectin significantly influences prognosis in osteosarcoma.
Shi K, et al.
International Journal of Clinical and Experimental Pathology, 8, 11364-11371 (2015)
Masato Nagaoka et al.
PloS one, 10(8), e0136350-e0136350 (2015-08-27)
Maintenance and differentiation of human pluripotent stem cells (hPSCs) usually requires culture on a substrate for cell adhesion. A commonly used substratum is Matrigel purified from Engelbreth-Holm-Swarm sarcoma cells, and consists of a complex mixture of extracellular matrix proteins, proteoglycans
Degradation of distinct forms of multimeric vitronectin by human fibroblasts.
Wilkins-Port CE and McKeown-Longo PJ
Biochimica et Biophysica Acta, 1404, 353-366 (1998)
Masaki Ikeda et al.
BMC microbiology, 15, 263-263 (2015-11-18)
Nontypeable Haemophilus influenzae (NTHi) is one of the most common Gram-negative pathogens in otitis media and exacerbation of chronic obstructive pulmonary disease. NTHi has been reported to invade bronchial epithelial cells. This penetration enables NTHi to evade the host immune
Sharron Chow et al.
Investigative ophthalmology & visual science, 55(10), 6590-6600 (2014-09-23)
The stratified squamous epithelial covering of the cornea provides one of the first physical and immunological lines of defense. A breach in its integrity results in a wound healing response that resolves quickly. However, under certain conditions-for example, when migrating
Tae-Jin Lee et al.
Biochemical and biophysical research communications, 452(1), 174-180 (2014-08-26)
Graphene has drawn attention as a substrate for stem cell culture and has been reported to stimulate the differentiation of multipotent adult stem cells. Here, we report that graphene enhances the cardiomyogenic differentiation of human embryonic stem cells (hESCs) at
Lynn Yap et al.
Cell reports, 26(12), 3231-3245 (2019-03-21)
Regeneration of injured human heart muscle is limited and an unmet clinical need. There are no methods for the reproducible generation of clinical-quality stem cell-derived cardiovascular progenitors (CVPs). We identified laminin-221 (LN-221) as the most likely expressed cardiac laminin. We
Identification of outer membrane Porin D as a vitronectin-binding factor in cystic fibrosis clinical isolates of Pseudomonas aeruginosa.
Paulsson M, et al.
Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society, 14, 600-607 (2015)
Stefan R Braam et al.
Stem cells (Dayton, Ohio), 26(9), 2257-2265 (2008-07-05)
Defined growth conditions are essential for many applications of human embryonic stem cells (hESC). Most defined media are presently used in combination with Matrigel, a partially defined extracellular matrix (ECM) extract from mouse sarcoma. Here, we defined ECM requirements of
Distribution of vitronectin mRNA during murine development.
Seiffert D, et al.
Developmental Dynamics, 203, 71-79 (1995)
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