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Gang Liu et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(11), 8553-8558 (2015-06-04)
Aberrant expression of the Cullin 4A (CUL4A) is found in many tumor types, but the functions and mechanism of CUL4A in prostate cancer (PCa) development and progression remain largely unknown. The aim of this study was to investigate the possible
Wei Liu et al.
Oncology reports, 32(5), 1853-1860 (2014-08-15)
Hiwi, also named PiwiL1, is a human homologue of the Piwi family which is associated with stem cells and is overexpressed in several types of cancers. In the present study, we aimed to investigate the role of Hiwi in cervical
Cassandra L Weaver et al.
Advanced healthcare materials, 4(9), 1408-1416 (2015-05-07)
Neural stem cell (NSC) transplantation has the potential to restore function to diseased or damaged nervous tissue, but poor control over cell survival, differentiation, and maturation limits therapeutic prospects. Engineered scaffolds that have the ability to drive neural stem cell
A R Fernandes et al.
Integrative biology : quantitative biosciences from nano to macro, 6(9), 855-861 (2014-07-16)
Evaluating the uptake and handling of biomedically relevant nanoparticles by cells of the nervous system critically underpins the effective use of nanoparticle platforms for neuro-regenerative therapies. The lack of biologically relevant and 'neuromimetic' models for nanomaterials testing (that can simulate
Sota Takanezawa et al.
Biophysical journal, 108(9), 2148-2157 (2015-05-09)
Cell fates change dynamically in response to various extracellular signals, including growth factors that stimulate differentiation and proliferation. The processes underlying cell-fate decisions are complex and often include large cell-to-cell variations, even within a clonal population in the same environment.
B P Kaistha et al.
British journal of cancer, 111(9), 1780-1787 (2014-08-20)
Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive human malignancies with an overall 5-year survival rate of <5%. Despite significant advances in treatment of the disease during the past decade, the median survival rate (∼6 months) has hardly improved
Colette A Bichsel et al.
Tissue engineering. Part A, 21(15-16), 2166-2176 (2015-04-22)
The formation of blood vessels is a complex tissue-specific process that plays a pivotal role during developmental processes, in wound healing, cancer progression, fibrosis, and other pathologies. To study vasculogenesis and vascular remodeling in the context of the lung, we
Noriaki Hashimoto et al.
BMC cancer, 14, 722-722 (2014-09-28)
Cancer stem cells (CSCs) are thought to play important roles in therapy-resistance. In this study, we induced cancer stem-like cells from hepatocellular carcinoma (HCC) cell lines using a unique medium, and examined their potential for resistance to anti-cancer drugs. The
A Dudley et al.
Oncogene, 33(41), 4952-4960 (2013-10-22)
Glioblastoma (GBM) is the most common and invasive adult brain cancer. The rapid invasion of cancer cells into the normal brain is a major cause of treatment failure, yet the mechanisms that regulate this process are poorly understood. We have
David J Sharkey et al.
Molecular and cellular endocrinology, 417, 178-190 (2015-09-30)
Seminal fluid induces pro-inflammatory cytokines and elicits an inflammation-like response in the cervix. Here, Affymetrix microarray and qPCR was utilised to identify activin A (INHBA) and its inhibitor follistatin (FST) amongst the cytokines induced by seminal plasma in Ect1 ectocervical
Tracey A Martin et al.
Oncology reports, 32(1), 213-224 (2014-05-27)
Hepatocyte growth factor (HGF) may impact the metastasis of prostate cancer via its action on prostate stem cells or their progeny. Tight junctions (TJs) are crucial to the process of metastasis and have been previously shown to be regulated by
Tamotsu Kiyoshima et al.
Stem cell research, 12(1), 309-322 (2013-12-18)
Previous studies have shown that the recombination of cells liberated from developing tooth germs develop into teeth. However, it is difficult to use human developing tooth germ as a source of cells because of ethical issues. Previous studies have reported
Gianfranca Miconi et al.
Journal of cellular biochemistry, 116(5), 864-876 (2015-01-07)
Recently, glioma stem cells have been identified as the main cause of glioma propagation and recurrence and a number of several cell markers have been indicated as putative GSC markers. In the present work, a retrospective study to evaluate the
Mi-Ra Choi et al.
International journal of clinical and experimental pathology, 8(5), 5236-5241 (2015-07-21)
Epidermal keratinocytes provide protective role against external stimuli by barrier formation. In addition, kertinocytes exerts their role as the defense cells via activation of innate immunity. Disturbance of keratinocyte functions is related with skin disorders. Psoriasis is a common skin
Cheol-Jung Lee et al.
BMC cancer, 15, 576-576 (2015-08-09)
Magnolin is a natural compound abundantly found in Magnolia flos, which has been traditionally used in oriental medicine to treat headaches, nasal congestion and anti-inflammatory reactions. Our recent results have demonstrated that magnolin targets the active pockets of ERK1 and
Ming-Jer Young et al.
Carcinogenesis, 36(4), 498-507 (2015-03-07)
Aldehyde dehydrogenase 1 (ALDH1) is a cancer stem-like cell (CSC) marker in human cancers; however, the specific ALDH1-regulated function and its underlying signalling pathways have not been fully demonstrated. Here, we investigated the ALDH1-regulated function and its underlying signalling and
Yun-Suk Kwon et al.
Oncology reports, 34(2), 884-890 (2015-06-13)
The quiescent state plays an important role in tumor recurrence because it protects cancer cells from chemotherapy. Previously, we optimized tumorsphere cultures for in vitro screening methods for targeting quiescent cell population since the majority of cells in tumorspheres are
Andrey A Rosenkranz et al.
International journal of radiation oncology, biology, physics, 72(1), 193-200 (2008-08-30)
To generate and evaluate a modular recombinant transporter (MRT) for targeting 211 At to cancer cells overexpressing the epidermal growth factor receptor (EGFR). The MRT was produced with four functional modules: (1) human epidermal growth factor as the internalizable ligand
Ashleigh Poole et al.
Journal of cellular physiology, 231(3), 650-658 (2015-07-29)
Transient FGF stimulation of various cell types results in FGF memory--a sustained blockage of efficient proliferative response to FGF and other growth factors. FGF memory establishment requires HDAC activity, indicating its epigenetic character. FGF treatment stimulates proinflammatory NFκB signaling, which
Lorraine Frew et al.
PloS one, 9(8), e103434-e103434 (2014-08-05)
hCAP18/LL-37 is the sole human cathelicidin; a family of host defence peptides with key roles in innate host defence. hCAP18/LL-37 is expressed primarily by neutrophils and epithelial cells, but its production and function in the lower genital tract is largely
Zheng Jun Li et al.
The Journal of investigative dermatology, 134(11), 2747-2756 (2014-05-14)
Propionibacterium acne and sebaceous glands are considered to have an important role in the development of acne. Although information regarding the activation of innate immunity by P. acnes in the sebaceous gland is limited, different P. acnes phylotypes and a
Chitra Venugopal et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(23), 5324-5337 (2015-07-15)
Clonal evolution of cancer may be regulated by determinants of stemness, specifically self-renewal, and current therapies have not considered how genetic perturbations or properties of stemness affect such functional processes. Glioblastoma-initiating cells (GICs), identified by expression of the cell surface
Sabine M Brouxhon et al.
Molecular carcinogenesis, 53(11), 893-906 (2013-06-19)
Recent literature suggests that sEcad exerts pro-oncogenic effects, possibly acting as a ligand for the human epidermal growth factor family. Here we show that sEcad is a novel candidate protein for drug targeting since it is increased in human and
Yanhong Hao et al.
Cloning and stem cells, 11(1), 101-110 (2009-02-20)
Although transgenic animal production through somatic cell nuclear transfer (SCNT) has been successful, the process is still inefficient. One major limitation is the use of somatic donor cells that have a finite life span. Identification and isolation of a cell
Chang Yu et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 36(6), 2393-2402 (2015-08-19)
Primary hepatocellular carcinoma (HCC) is highly invasive, and often results in an early distal metastasis resulting in poor prognosis and therapeutic outcome. Cancer cells disseminating from the tumor and entering circulation are termed circulating tumor cells (CTCs). Although substantial progress
Paula J Hurley et al.
Cancer research, 75(20), 4322-4334 (2015-08-22)
Prostate cancer is a leading cause of cancer death in men due to the subset of cancers that progress to metastasis. Prostate cancers are thought to be hardwired to androgen receptor (AR) signaling, but AR-regulated changes in the prostate that
Milton L Greenberg et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(22), E2349-E2355 (2014-05-21)
Neural precursor cells (NPCs) offer a promising approach for treating demyelinating diseases. However, the cellular dynamics that underlie transplanted NPC-mediated remyelination have not been described. Using two-photon imaging of a newly developed ventral spinal cord preparation and a viral model
Radhika Susarla et al.
PloS one, 9(4), e94913-e94913 (2014-04-17)
Innate immune responses have a critical role in regulating sight-threatening ocular surface (OcS) inflammation. While glucocorticoids (GCs) are frequently used to limit tissue damage, the role of intracrine GC (cortisol) bioavailability via 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in OcS defense
Kurodo Koshino et al.
World journal of gastroenterology, 21(17), 5242-5249 (2015-05-09)
To create a new rat model for drug administration, cell transplantation, and endoscopic examination for the treatment of intestinal diseases. F344/NJc l-rnu/rnu rats (10-wk-old males, 350-400 g) were used in this study. The rats were anesthetized via 2% isoflurane inhalation.
Neurotrophic actions of a novel molluscan epidermal growth factor.
Hermann PM
The Journal of Neuroscience, 20, 6355-6364 (2000)
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