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Song Chen et al.
Experimental eye research, 127, 26-36 (2014-06-01)
CD73 is intensively involved in the regulation of immune responses through the conversion of pro-inflammatory ATP to immunosuppressive adenosine. Herein, we clarified whether cells in the retina express CD73 and participate in the regulation of inflammatory eye diseases such as
Xiangrui Wang et al.
Water research, 138, 224-233 (2018-03-31)
It is now widely accepted that coating on the nano-surface would critically dictate the uptake and cytotoxicity of engineering nanomaterials. However, the influence of natural organic matter (NOM) on the surface is quite limited to humic substances, while the diversity
Fabiana Russo et al.
Environmental science and pollution research international, 26(24), 24445-24461 (2019-06-23)
The study of the soil microbial community represents an important step in better understanding the environmental context. Therefore, biological characterisation and physicochemical integration are keys when defining contaminated sites. Fungi play a fundamental role in the soil, by providing and
Lorenzo Guerra et al.
Pediatric pulmonology, 52(7), 900-908 (2017-04-27)
The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) potentiator ivacaftor (Kalydeco®) improves clinical outcome in G551D cystic fibrosis (CF) patients. Here, we have investigated whether ivacaftor has a clinical impact on non-G551D gating mutations and function of circulating leukocytes as well.
Ester Sara Di Filippo et al.
Journal of applied physiology (Bethesda, Md. : 1985), 123(3), 501-512 (2017-06-03)
The aim of this study was to determine whether neuromuscular electrical stimulation (NMES) affects skeletal muscle regeneration through a reduction of oxidative status in satellite cells of healthy elderly subjects. Satellite cells from the vastus lateralis skeletal muscle of 12
A P Subhawong et al.
Acta cytologica, 56(4), 463-466 (2012-08-01)
Hairy cell leukemia (HCL) usually presents with peripheral cytopenias, diffuse marrow infiltration, and splenomegaly. This chronic lymphoproliferative disorder is not typically associated with lymphadenopathy or mass lesions. We report a case of HCL first treated by splenectomy, followed by several
Ji Hyun Shin et al.
Biochemical and biophysical research communications, 460(2), 428-433 (2015-03-23)
Previously, we showed that BIX-01294 treatment strongly activates autophagy. Although, the interplay between autophagy and ciliogenesis has been suggested, the role of autophagy in ciliogenesis is controversial and largely unknown. In this study, we investigated the effects of autophagy induced
Yogesh M Kulkarni et al.
Journal of cellular physiology, 231(4), 817-828 (2015-08-13)
We have synthesized a novel derivative of Digitoxin, termed "MonoD", which demonstrates cytotoxic effects in lung cancer cells with much higher potency as compared to Digitoxin. Our data show that within 1 h of MonoD treatment, H460 cells showed increased oxidative
Ariadne Vlahakis et al.
The Journal of cell biology, 215(6), 779-788 (2016-12-03)
Autophagy is a catabolic process that recycles cytoplasmic contents and is crucial for cell survival during stress. The target of rapamycin (TOR) kinase regulates autophagy as part of two distinct protein complexes, TORC1 and TORC2. TORC1 negatively regulates autophagy according
Wenquan Liang et al.
Scientific reports, 6, 38267-38267 (2016-12-03)
The prognosis of gastric cancer remains poor due to clinical drug resistance. Novel drugs are urgently needed. Shikonin (SHK), a natural naphthoquinone, has been reported to trigger cell death and overcome drug resistance in anti-tumour therapy. In this study, we
Michael A Rosenbaum et al.
Atherosclerosis, 241(2), 709-715 (2015-07-01)
Endothelial cell (EC) migration is essential for healing of arterial injuries caused by angioplasty, but a high cholesterol diet inhibits endothelial repair. In vivo studies suggest that apolipoprotein A-I (apoA-I), the major protein constituent of HDL, is essential for normal healing
Yoonseon Jeong et al.
Nutrients, 11(4) (2019-04-04)
Generation of excess quantities of reactive oxygen species (ROS) caused by mitochondrial dysfunction facilitates rapid growth of pancreatic cancer cells. Elevated ROS levels in cancer cells cause an anti-apoptotic effect by activating survival signaling pathways, such as NF-κB and its
Michael Kohlhaas et al.
The Journal of physiology, 595(12), 3781-3798 (2017-02-24)
In the heart, endothelial nitric oxide (NO) controls oxygen consumption in the working heart through paracrine mechanisms. While cardiac myocytes contain several isoforms of NO synthases, it is unclear whether these can control respiration in an intracrine fashion. A long-standing
Xiangdong Wang et al.
International journal of radiation biology, 91(5), 452-458 (2015-02-05)
Autophagy plays a crucial role in cellular response to ionizing radiation, but it is unclear whether autophagy can modulate radiation-induced bystander effect (RIBE). Here, we investigated the relationship between bystander damage and autophagy in human hepatoma cells of HepG2. HepG2
Raísha Costa Martins et al.
International immunopharmacology, 63, 101-109 (2018-08-06)
The available chemotherapeutic drugs for the treatment of leishmaniasis present problems relating to efficacy, emergence of parasite resistance, and adverse effects and cost. Azole antifungal drugs have been repurposed for this proposition but the clinical response has been variable. In
Dingfu Xiao et al.
Oxidative medicine and cellular longevity, 2019, 9719618-9719618 (2019-10-01)
Eucommia ulmoides flavones (EUF) have been demonstrated to alleviate oxidative stress and intestinal damage in piglets, but their effect target is still poorly understood. NF-E2-related factor 2 (Nrf2) pathway plays a very important role in the defense mechanism. This study
Xiangxing Chen et al.
Journal of agricultural and food chemistry, 65(19), 3986-3994 (2017-04-28)
We investigated the relationship between meat quality and oxidative damage caused by hydrogen peroxide (H
Huang-Hui Chen et al.
Free radical biology & medicine, 113, 505-518 (2017-10-31)
Nuclear factor erythroid-2-related factor 2 (NRF2) mainly regulates transcriptional activation through antioxidant-responsive elements (AREs) present in the promoters of NRF2 target genes. Recently, we found that NRF2 was overexpressed in a KB-derived drug-resistant cancer cell panel. In this panel, KB-7D
Kayla Borland et al.
Genes, 10(1) (2019-01-10)
Post-transcriptional RNA modifications have been found to be present in a wide variety of organisms and in different types of RNA. Nucleoside modifications are interesting due to their already known roles in translation fidelity, enzyme recognition, disease progression, and RNA
Ming-Wei Liu et al.
BMC complementary and alternative medicine, 16, 11-11 (2016-01-14)
Puerarin, extracted from Radix puerariae, was reported to ameliorate airway inflammation, lung injury and lung fibrosis induced by paraquat (PQ) in mice. However, effects of Radix puerariae extracts (RPEs) on lung fibrosis or signalling pathways in PQ-induced lung injury have
Monique Cunha de Padua et al.
Oncotarget, 8(50), 87623-87637 (2017-11-21)
As Otto Warburg first observed, cancer cells largely favor fermentative glycolysis for growth even under aerobic conditions. This energy paradox also extends to rapidly growing normal cells indicating that glycolysis is optimal for fast growth and biomass production. Here we
Amal Kouadri et al.
Antioxidants & redox signaling, 31(1), 59-74 (2018-12-21)
Aim: Bronchial epithelium acts as a defensive barrier against inhaled pollutants and microorganisms. This barrier is often compromised in
E Singer et al.
Cell death & disease, 6, e1601-e1601 (2015-01-16)
Glioblastoma (GBM) resistance to therapy is the most common cause of tumor recurrence, which is ultimately fatal in 90% of the patients 5 years after initial diagnosis. A sub-population of tumor cells with stem-like properties, glioma stem cells (GSCs), is
Joanna Skalska et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 97, 307-315 (2016-10-30)
While it is known that silver nanoparticles (AgNPs) can enter the brain, our knowledge of AgNP-induced neurotoxicity remains incomplete. We investigated the ability of 10 nm citrate-stabilized AgNPs to generate oxidative stress in brain and liver of adult male Wistar rats
Joy Marie Fulbright et al.
Cancer chemotherapy and pharmacology, 76(6), 1297-1307 (2015-10-31)
Cardiotoxic side effects of anthracyclines limit their use as effective chemotherapeutics. One mechanistic model of anthracycline-induced cardiotoxicity is attributed to the generation of intracellular reactive oxygen species (ROS). However, this theory has been questioned because several cardioprotective strategies have included
Miguel Mendivil-Perez et al.
Anti-cancer drugs, 26(6), 583-598 (2015-03-04)
In this study, we investigated the molecular mechanism of doxorubicin (dxr)-induced cytotoxicity on Jurkat cells - a model cell of human acute lymphoblastic leukemia - under normoxic (20% O2) and hypoxic (5% O2) conditions. Using in-cell western analysis, immunofluorescence, flow
Hyun Ah Lee et al.
Molecular medicine reports, 15(4), 1613-1623 (2017-03-06)
Asparagus cochinchinesis (A. cochinchinesis) is a medicine traditionally used to treat fever, cough, kidney disease, breast cancer, inflammatory disease and brain disease in northeast Asian countries. Although numerous studies of the anti‑inflammatory effects of A. cochinchinesis have been conducted, the underlying mechanisms of
Yan-Liang Li et al.
Oncotarget, 8(1), 1508-1528 (2016-12-03)
Radiotherapy is an integral part for the treatment of head and neck cancer (HNC), while radioresistance is a major cause leads to treatment failure. GDF15, a member of the TGF-β superfamily, is hypothesized to participate in various types of homeostasis.
Berenika Szczęśniak-Sięga et al.
Acta biochimica Polonica, 65(2), 199-207 (2018-06-16)
Oxicams (e.g. piroxicam, meloxicam) are widely used nonsteroidal anti-inflammatory drugs (NSAIDs). A large body of evidence from epidemiological and preclinical studies has shown that NSAIDs have a chemopreventive effect on different types of cancer, especially in colorectal cancer. Moreover, mounting
Shihui Liu et al.
Oncotarget, 8(39), 65123-65131 (2017-10-17)
Anthrax lethal toxin is a typical A-B type protein toxin secreted by
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