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Christina Zbinden et al.
Veterinary microbiology, 179(3-4), 336-340 (2015-07-28)
Mycoplasma bovis is an emerging bacterial agent causing bovine mastitis. Although these cell wall-free bacteria lack classical virulence factors, they are able to activate the immune system of the host. However, effects on the bovine mammary immune system are not
Justin L Luebke et al.
Metallomics : integrated biometal science, 5(4), 335-342 (2013-02-07)
Staphylococcus aureus CstR (CsoR-like sulfur transferase repressor) is a member of the CsoR family of transition metal sensing metalloregulatory proteins. Unlike CsoR, CstR does not form a stable complex with transition metals but instead reacts with sulfite to form a
Maria Angeles Fernandez-Estevez et al.
PloS one, 9(2), e90202-e90202 (2014-03-04)
Huntington's disease (HD) is a neurodegenerative disorder characterized by progressive motor, cognitive and psychiatric deficits, associated with predominant loss of striatal neurons and is caused by polyglutamine expansion in the huntingtin protein. Mutant huntingtin protein and its fragments are resistant
Larbi Amazit et al.
The Journal of biological chemistry, 290(36), 21876-21889 (2015-07-24)
Aldosterone regulates sodium homeostasis by activating the mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily. Hyperaldosteronism leads todeleterious effects on the kidney, blood vessels, and heart. Although steroidal antagonists such as spironolactone and eplerenone are clinically useful for
Hui Liu et al.
The Journal of steroid biochemistry and molecular biology, 144 Pt B, 483-491 (2014-09-24)
Leydig cells are the primary source of testosterone in the testes, and their steroidogenic function is strictly controlled by the hypothalamus-pituitary-gonad axis. Emerging evidence has indicated that fibroblast growth factors play a role in regulating stem Leydig cell development and
Dan Vershkov et al.
Cell reports, 26(10), 2531-2539 (2019-03-07)
Fragile X syndrome (FXS) is caused primarily by a CGG repeat expansion in the FMR1 gene that triggers its transcriptional silencing. In order to investigate the regulatory layers involved in FMR1 inactivation, we tested a collection of chromatin modulators for
Dongwook Lee et al.
Fish physiology and biochemistry, 41(6), 1569-1576 (2015-08-05)
This study was conducted to identify embryonic stem cell (ESC) activities of a long-term cultured embryonic cell line previously derived from blastula-stage Oryzias dancena embryos. Five sub-cell lines were established from the embryonic cell line via clonal expansion of single
Suk Ho Bhang et al.
Biomaterials, 55, 33-43 (2015-05-03)
At high concentrations, manganese (Mn) promotes cellular neurodevelopment but causes toxicity. Here, we report that Mn ion at high concentrations can be delivered to pheochromocytoma 12 (PC12) cells using gold nanoparticles (AuNPs) to enhance cellular neurodevelopment without toxicity. Mn(2+) release
Zhen Cheng et al.
Frontiers in oncology, 11, 668424-668424 (2021-06-08)
Thyroid cancer is the most common endocrine malignancy, and its incidence has increased in the past decades. Selenium has been shown to have therapeutic effects against several tumors. However, its role in thyroid cancer and its underlying molecular mechanism remains
Urška Kristan et al.
Biological trace element research, 151(2), 240-246 (2012-12-18)
The distribution and speciation of selenium (Se) in freshwater fish (muscle and liver tissue) from lakes in Argentina was investigated. Three introduced species, brown trout (Salmo trutta), rainbow trout (Oncorhynchus mykiss) and brook trout (Salvelinus fontinalis), and one native species
J I Eze et al.
Experimental parasitology, 135(2), 331-336 (2013-08-07)
Trypanosomosis has been associated with immunosuppression, anemia and oxidative damage while selenium possesses both immunostimulatory and antioxidative effects. This study was designed to assess the effect of dietary selenium supplementation on parasitemia, anemia, survival pattern and serum protein profiles of
Towards obtaining long term embryonic stem cell like cultures from a marine flatfish, Scophtalmus maximus
Holen E and Hamre K
Fish Physiology and Biochemistry, 29(3), 245-252 (2003)
Maren Lindner et al.
Brain : a journal of neurology, 138(Pt 7), 1875-1893 (2015-04-25)
Remyelination failure plays an important role in the pathophysiology of multiple sclerosis, but the underlying cellular and molecular mechanisms remain poorly understood. We now report actively demyelinating lesions in patients with multiple sclerosis are associated with increased glial expression of
C I O'Connor-Robison et al.
Journal of animal science, 92(10), 4607-4615 (2014-09-04)
Dietary long-chain PFO including arachidonic acid (ARA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) are precursors for several inflammatory mediators. The objective of this study was to characterize the effects of dietary PFO supplementation on bone, cartilage, and synovial fluid
Tao Yin et al.
PloS one, 9(12), e114581-e114581 (2014-12-19)
According to the cancer stem cells (CSCs) theory, malignant tumors may be heterogeneous in which a small population of CSCs drive the progression of cancer. Because of their intrinsic abilities, CSCs may survive a variety of treatments and then lead
Kejian Shi et al.
Journal of hematology & oncology, 6, 7-7 (2013-01-19)
Previous studies demonstrated that selenite induced cancer-cell apoptosis through multiple mechanisms; however, effects of selenite on microtubules in leukemic cells have not been demonstrated. The toxic effect of selenite on leukemic HL60 cells was performed with cell counting kit 8.
Yongchao Li et al.
American journal of physiology. Cell physiology, 309(8), C532-C540 (2015-08-14)
Loss of oligodendrocytes as the result of central nervous system disease causes demyelination that impairs axon function. Effective directional migration of endogenous or grafted oligodendrocyte precursor cells (OPCs) to a lesion is crucial in the neural remyelination process. In this
Meiling Li et al.
Cellular signalling, 26(7), 1539-1548 (2014-04-08)
Progranulin (PGRN) was reported to be a stress-response factor in response to hypoxia and acidosis. Here we present evidences demonstrating that PGRN is also an endoplasmic reticulum (ER) stress responsive factor: PGRN expression was induced and its activation of Erk1/2
Laetitia Asser et al.
Molecular and cellular endocrinology, 395(1-2), 1-9 (2014-07-25)
Glucocorticoid receptor (GR), a ubiquitous transcriptional factor, regulates target gene expression upon activation by glucocorticoids, notably cortisol, a corticosteroid hormone synthesized in the adrenal cortex. We thus hypothesized that both GR and cortisol might be involved in the regulation of
C Linscheid et al.
Placenta, 36(8), 832-838 (2015-06-23)
Maternal T-cells reactive towards paternally inherited fetal minor histocompatibility antigens are expanded during pregnancy. Placental trophoblast cells express at least four fetal antigens, including human minor histocompatibility antigen 1 (HA-1). We investigated oxygen as a potential regulator of HA-1 and
Qingjie Wang et al.
American journal of physiology. Heart and circulatory physiology, 309(11), H1894-H1903 (2015-10-11)
Epoxyeicosatrienoic acids (EETs) have beneficial effects on cardiovascular disease. Soluble epoxide hydrolase (sEH) metabolizes EETs to less active diols, thus diminishing their biological activity. sEH inhibitors can suppress the progression of atherosclerotic lesions in animal models. However, the regulation of
Takeshi Imai et al.
Bioscience, biotechnology, and biochemistry, 78(8), 1376-1380 (2014-08-19)
Selenite is a selenium source for selenoprotein biosynthesis in mammalian cells. Although previous studies have suggested the involvement of glutathione (GSH) and/or thioredoxin reductase in selenite metabolism, intracellular selenite metabolism remains largely unknown. Here, we report that GSH depletion did
Hitoshi Ueno et al.
Biological & pharmaceutical bulletin, 37(8), 1352-1358 (2014-08-05)
Although supplementation with the selenocompound, sodium selenite has been shown to stimulate the concanavalin A-induced T-cell mitogenic response, the mechanisms responsible remain unclear. This study was conducted to evaluate the relationships between the induction of apoptosis, formation of tumor necrosis
Fabiola Rusolo et al.
Molecules (Basel, Switzerland), 18(3), 2549-2562 (2013-02-28)
The need to explore new alternative therapeutic strategies and chemoprevention methods for hepatocellular carcinoma is growing significantly. Selenium is a trace element that plays a critical role in physiological processes, and is used in cancer chemoprevention. The aim of this
María Sancho-Tello et al.
The International journal of artificial organs, 38(4), 210-223 (2015-05-09)
Tissue engineering techniques were used to study cartilage repair over a 12-month period in a rabbit model. A full-depth chondral defect along with subchondral bone injury were originated in the knee joint, where a biostable porous scaffold was implanted, synthesized
Priscilla Soulié et al.
American journal of physiology. Cell physiology, 307(8), C745-C759 (2014-08-29)
Generation of branched tubes from an epithelial bud is a fundamental process in development. We hypothesized that induction of hyaluronan synthase (Has) and production of hyaluronan (HA) drives tubulogenesis in response to morphogenetic cytokines. Treatment of J3B1A mammary cells with
Małgorzata Anita Bryszewska et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 29, 91-98 (2014-12-04)
In this study, we investigate the type and quantity of selenium compounds in fish and marine organisms, using ion-pair reversed phase LC–ICP-MS, developed and applied for the analysis of Atlantic cod, Atlantic salmon, Greenland halibut, Atlantic herring, blue mussel, common
Yosuke Nakazawa et al.
Molecular vision, 21, 804-810 (2015-08-19)
This study investigated the ability of hesperetin, a natural flavonoid, to prevent selenite-induced cataracts in a rat model. Animals were divided into four treatment groups: G1 (control group), G2 (hesperetin-treated group), G3 (selenite-induced cataract group), and G4 (hesperetin-treated selenite cataract
Alexandra C Weaver et al.
Toxins, 6(12), 3336-3353 (2014-12-24)
To evaluate the effects of the mycotoxins deoxynivalenol (DON) and zearalenone (ZEA) on pigs and the benefits of two mycotoxin mitigation strategies, gilts (n = 84, 9.1 ± 0.1 kg) were allotted to four treatments: CON (control); MT (4.8 mg/kg
Hitoshi Ueno et al.
Biological & pharmaceutical bulletin, 37(9), 1569-1574 (2014-09-02)
The effects of administering the selenocompounds, sodium selenite, methylseleninic acid (MSA), and seleno-L-methionine (SeMet) on glucose tolerance were compared in the nicotinamide (NA) and streptozotocin (STZ)-induced diabetic mouse model. ICR mice were intraperitoneally treated twice with STZ (100 mg/kg) 15 min after
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